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Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. Additionally we are shipping Carbonic Anhydrase IX Antibodies (287) and Carbonic Anhydrase IX Proteins (22) and many more products for this protein.
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Authors demonstrate that CAIX associates with MMP14 (show MMP14 ELISA Kits) through potential phosphorylation residues within its intracellular domain, and that CAIX enhances MMP14 (show MMP14 ELISA Kits)-mediated collagen degradation by directly contributing hydrogen ions required for MMP14 (show MMP14 ELISA Kits) catalytic activity.
Loss of Function Screening Reveals Carbonic Anhydrase IX as a Key Modulator of Tumor Initiating Potential in Primary Pancreatic Tumors.
constitutive activation of the NF-kappaB (show NFKB1 ELISA Kits) pathway in CAIX-depleted cells restored G-CSF (show CSF3 ELISA Kits) secretion
Downregulation of carbonic anhydrase IX promotes Col10a1 (show COL10A1 ELISA Kits) expression in chondrocytes.
CA IX may directly or indirectly play novel functions in brain tissue.
Data show that CA9, GLUT1 (show SLC2A1 ELISA Kits) and LOX (show LOX ELISA Kits) mRNA levels were equally and strongly correlated to hypoxic extent in FaDudd, and the same profile was observed for CA9 and GLUT1 (show SLC2A1 ELISA Kits), but not LOX (show LOX ELISA Kits), in SCCVII tumors.
a novel role for CA IX in the regulation of immunologic processes and digestion
although CA IX-deficiency is not a tumor-promoting factor per se, it induces glandular atrophy in the body mucosa, a lesion which is considered to be a preneoplastic alteration in the stomach
These results suggest that the loss of function of cytosolic CA II (show CA2 ELISA Kits) in the stomach of Car2 (show CA2 ELISA Kits)-/- mice leads to up-regulation of an extracellular CA, namely CA IX, which is expressed on the cell surface of the gastric epithelium.
CA9 may regulate ion and pH homeostasis within the developing embryo.
Data show that targeting the hypoxic tumor compartment by knockdown of carbonic anhydrase IX (CAIX) using short hairpin RNA or by chemical inhibition of CAIX with acetazolamide potentiates the anti-cancer activity of mTOR (show FRAP1 ELISA Kits) inhibitors rapamycin.
Results provide evidence that CAIX induces chemoresistance of A549 cells, a lung cancer cell line.
The results suggest the possibility that CA9 exosomes released from hypoxic RCC (show XRCC1 ELISA Kits) may enhance angiogenesis in microenvironment, thereby contributing to cancer progression.
CA9 expression is highly associated with distant metastases, including para-aortic involvement.
Increased miR (show MLXIP ELISA Kits)-210 and concomitant decreased ISCU (show ISCU ELISA Kits) RNA levels were found in ~40% of tumors and this was significantly associated with HIF-1alpha (show HIF1A ELISA Kits) and CAIX, but not MCT1 (show CMA1 ELISA Kits) or MCT4, over-expression.
describe the identification of the structural determinants responsible for the CA IX/CAND1 (show CAND1 ELISA Kits) interaction
Data suggest that CAIX (carbonic anhydrase IX) is a novel downstream mediator of asTF (alternatively spliced tissue factor (show F3 ELISA Kits)) in pancreatic ductal adenocarcinoma, particularly under hypoxic conditions that model late-stage tumor microenvironment; tumor hypoxia appears to lead to up-regulation of CAIX expression (or 'activation'), which is more pronounced in tumor cells overexpressing asTF.
Our findings suggest that LCN2 (show LCN2 ELISA Kits) suppresses tumour metastasis by targeting the transcriptional and post-transcriptional regulation of CAIX in oral squamous cell carcinoma
CA II (show CA2 ELISA Kits) and CA XII, but not CA VII (show CA7 ELISA Kits) or CA IX, could be useful in predicting survival in colorectal carcinomas
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.
carbonic anhydrase IX
, carbonic anhydrase 9
, carbonate dehydratase IX
, membrane antigen MN homolog
, RCC-associated antigen G250
, RCC-associated protein G250
, carbonic dehydratase
, membrane antigen MN
, renal cell carcinoma-associated antigen G250