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The protein encoded by CA8 is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Additionally we are shipping Carbonic Anhydrase VIII Antibodies (76) and Carbonic Anhydrase VIII Proteins (17) and many more products for this protein.
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This study demonstrated that the Climbing Fiber Development of cerebellum Is Impaired in Postnatal Car8 (wdl) Mice.
Dorsal root ganglion (DRG) carbonic anhydrase 8 (Car8) expression is variable across 25 naive-inbred strains of mice, and this cis-regulated quantitative trait locus is correlated with nociceptive responses in mice. Mean DRG Car8 gene expression is directly related to the dose of morphine or clonidine needed to provide a half-maximal analgesic response.
CA8 is a novel important regulator of Purkinje cell dendritic development and that its expression is controlled by PKCgamma activity.
Car8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway.
Results indicate a widespread disruption in cerebellar circuitry hampering proper neuronal communication in CAR8 mutant mice
CA8 overexpression desensitizes neuronal cells to STS induced apoptotic stress and increases cell migration and invasion ability in neuronal cells.
The datum of this study provide evidence that the CAVIII protein, which is highly conserved in vertebrates, is selectively expressed within neural circuits, and may be important for modulating retinal neurotransmission.
Results describe the tissue distribution of carbonic anhydrase-related proteins VIII, X, and XI and their developmental expression in the murine embryonic brain.
CAR8 plays a central role in motor control; data indicate that the waddles mouse is a Car8 null mutant.
Car8 plays a critical role in synaptogenesis and/or maintenance of proper synaptic morphology and function in the cerebellum
We provide evidence that the CA8 gene product is indispensable in early embryonic development in zebra fi sh, particularly in the brain and eye.
results suggest that Sp1 transactivates hCA8 gene through the proximal GC box element in the promoter region
The CARP VIII and XI proteins were associated to non-hypoxic conditions and CARP XI also to the expression of cytoplasmic CA II staining suggesting that the CARPs play a role in tumorigenesis of diffusively infiltrating gliomas.
we observed increased expression of CA8 in more aggressive types of human osteosarcoma (OS) cells and found that CA8 expression is correlated with disease stages, such that more intense expression occurs in the disease late stage
Overexpression of CA8 in MERRF cybrids significantly decreases cell death.
This report expands the neurological and radiological phenotype associated with CA8 mutations.
review article describes the previous data on CARP VIII, including its structure, role in neurodegeneration and cancer; and bioinformatic and expression analyses.
Crystal structure of human carbonic anhydrase-related protein VIII reveals the basis for catalytic silencing
Overexpression of Carbonic anhydrase-related protein VIII promotes colon cancer cell growth
The results suggest that the variations of CA8 and CA10 loci may be important determinants of osteoporosis in Japanese women.
Consanguineous Iraqi family in which affected siblings had mild mental retardation and congenital ataxia characterized by quadrupedal gait. The mutation S100P is associated with proteasome-mediated degradation, and presumably represents a null mutation.
The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form.
carbonic anhydrase 8
, CA-RP VIII
, carbonic anhydrase VIII
, carbonic anhydrase-like sequence 1
, carbonic anhydrase-related protein
, CARP VIII
, CA-related protein
, carbonate dehydratase
, carbonic anhydrase-like sequence