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Carbonyl reductase is one of several monomeric, NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds. Additionally we are shipping CBR1 Antibodies (118) and CBR1 Proteins (22) and many more products for this protein.
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CRB1 (show CRB1 ELISA Kits) is an efficient catalyst for the reduction of glutathionylated aldehydes derived from lipid peroxidation.
The ability of human carbonyl reductase 1 to efficiently catalyze the reduction of glutathionylated aldehydes derived from lipid peroxidation, that in the case of glutathionylated-4-hydroxyalkanals is associated to the ability to oxidize the hemiacetal hydroxyl group
Data suggest that fatty acids and acyl-CoAs bind competitively with respect to substrate binding to carbonyl reductase 1 (CBR1), an enzyme involved in first-pass drug metabolism in intestinal mucosa; inhibition of CBR1 by these products of digestion may lead to food-drug interactions.
AKR1C3 (show AKR1C3 ELISA Kits) is the primary enzyme and CBR1 is a minor enzyme responsible for warfarin reduction in human liver cytosol.
These results suggest that CR1 (show CR1 ELISA Kits) induces apoptosis by activating the caspase (show CASP3 ELISA Kits) pathway via binding to TNFR1 (show TNFRSF1A ELISA Kits).
Critical insights into the substrate selectivity of hCBR1 and the interaction between hCBR1 and glutathione.
Up-Regulation of Carbonyl Reductase 1 Renders Development of Doxorubicin Resistance in Human Gastrointestinal Cancers
CBR1 decreases promoted tumor proliferation and growth as well as invasion and metastasis; CBR1 has potential to become a new candidate for molecular targeting therapy.
Inhibition of CBR1 may increase the efficacy of daunorubicin in cancer tissue.
Protein products of AKR1C1 (show DDH ELISA Kits), AKR1C2 (show AKR1C2 ELISA Kits), AKR7A3 (show AKR7A3 ELISA Kits), CYP3A4 (show CYP3A4 ELISA Kits), and carbonyl reductase (CBR1) were found in tumors and those of AKR1C1 (show DDH ELISA Kits), AKR7A3 (show AKR7A3 ELISA Kits), and CBR1 correlated with their transcript levels.
two Cys residues, Cys 149 and Cys 226, are involved in the enzyme activity; Cys 226 is involved in binding of the cofactor NADPH.
results indicate that the disturbances in 9-KPR activity in bovine retained placenta exist but their reasons still require further experiments
CBR1 plays a critical role in controlling redox balance and detoxifying lipid peroxidation during muscle differentiation and regeneration.
CBR1 attenuates apoptosis and promotes cell survival in pancreatic beta-cell lines under glucotoxic and glucolipotoxic conditions via reducing ROS (show ROS1 ELISA Kits) generation
Carbonyl reductase is one of several monomeric, NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds. This enzyme is widely distributed in human tissues. Another carbonyl reductase gene, CRB3, lies close to this gene on chromosome 21q.
carbonyl reductase [NADPH] 1
, carbonyl reductase 1
, 15-hydroxyprostaglandin dehydrogenase
, 20-beta-hydroxysteroid dehydrogenase
, NADPH-dependent carbonyl reductase 1
, prostaglandin 9-ketoreductase
, prostaglandin-E(2) 9-reductase
, carbonyl reductase
, carbonyl reductase (NADPH) 1
, short chain dehydrogenase/reductase family 21C, member 1
, 20-hydroxysteroid dehydrogenase
, prostaglandin E(2) 9-keto reductase
, NADPH:secondary-alcohol oxidoreductase
, Carbonyl reductase [NADPH] 1 (NADPH-dependent carbonyl reductase 1)
, Cbr 1