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Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols.
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Human Polyclonal CBR3 Primary Antibody for ELISA, WB - ABIN268608
Bains, Karkling, Lubieniecka, Grigliatti, Reid, Riggs: Naturally occurring variants of human CBR3 alter anthracycline in vitro metabolism. in The Journal of pharmacology and experimental therapeutics 2010
Show all 2 Pubmed References
No significant correlation between cardiotoxicity and SNPs within the CBR (show CBR1 Antibodies) pathway. Further investigation into CBR (show CBR1 Antibodies) SNPs in a larger adult sample is needed.
association of SNPs in ABCB1 (show ABCB1 Antibodies) and CBR3 with chronic cardiotoxicity in a cohort of breast cancer patients treated with anthracyclines.
Variants of CBR3 and GSTP1 (show GSTP1 Antibodies) enzymes may be associated with changes in short-term functional cardiac parameters.
genetic polymorphism in the CBR3 gene conferred risk of type 2 diabetes and insulin (show INS Antibodies) resistance in Chinese. The association was probably mediated through modulation of adipogenesis.
CBR3 polymorphisms contribute to increased cardiomyopathy risk associated with anthracycline treatment of childhood cancer.
CBR3 is a novel target gene of inflammatory stimuli; elucidation of its detailed role in inflammation deserves further investigation.
Computational searches identify a conserved antioxidant response element(ARE) in the distal carbonyl reductase 3 (CBR3) promoter region.
The CBR3 distal promoter contains an activating cis (show CISH Antibodies)-regulatory element that is responsive to Trichostatin A (TSA (show PRDX2 Antibodies)) treatment according to promoter reporter assays in HEK (show EPHA3 Antibodies) 293 cells.
a physiological role of CBR1 (show CBR1 Antibodies), but not for CBR3, in S-nitrosoglutathione reduction and thus ultimately in regulation of NO signaling
CBR3 is regulated via NRF2 (show GABPA Antibodies)-dependent signaling pathways, a finding and plays an important role in the cellular response to oxidative stress.
Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1.
carbonyl reductase 3
, NADPH-dependent carbonyl reductase 3
, carbonyl reductase (NADPH) 3
, carbonyl reductase [NADPH] 3
, short chain dehydrogenase/reductase family 21C, member 2