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Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides.
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Carboxypeptidase A5 (cpa5), a mast cell-specific enzyme, is expressed in zebrafish blood cells beginning at 24 hours post fertilization (hpf).
Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro region that assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region activates the enzyme (Wei et al., 2002
, carboxypeptidase A5
, carboxypeptidase A5-like