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CRTAC1 encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage.
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Confirm the increase of CRTAC1 in cartilage biopsies from OA patients undergoing joint replacement by real-time PCR and immunohistochemistry. Furthermore, we report that proinflammatory cytokines interleukin-1beta and tumor ne (show COL2A1 Antibodies)crosis factor alpha upregulate CRTAC1 expression in primary articular chondrocytes and synovial fibroblasts.
It was shown for the first time the propensity of CRTAC1 to form amyloid-like structures, and it was hypothesized that the aggregating property of CRTAC1 may be related to its disease-association.
These results provided new insights into the mechanism of cataract development, and demonstrated that CRTAC1 could be a potentially novel target for cataract treatment.
CRTAC1 acquired an alternate last exon from the tail-to-tail oriented neighbouring gene in humans resulting in the glycosylated isoform CRTAC1-A which represents a new extracellular matrix molecule of articular cartilage.
in bone fracture patients, 12 proteins were related to bone/cartilage metabolism, including: TGF-beta induced protein (show LMO7 Antibodies) IG-H(3), cartilage acidic protein 1, procollagen C proteinase enhancer protein (show PCOLCE Antibodies) and TGF-beta (show TGFB1 Antibodies) receptor III.
Genetic deletion of Crtac1 significantly inhibited cartilage degradation, osteophyte formation and gait abnormalities of post-traumatic OA in female, but not male, animals undergoing the destabilization of medial meniscus (DMM (show COL2A1 Antibodies)) surgery.
These data suggest that LOTUS functions as a potent endogenous antagonist for NgR1 (show NEUROG1 Antibodies) when bound by all four known NgR1 (show NEUROG1 Antibodies) ligands.
These findings suggest that the UA/EC region is a functional domain of LOTUS serving for an antagonistic action to NgR1 (show NEUROG1 Antibodies).
found CRTAC1-B(LOTUS)is key molecule for lateral olfactory tract(LOT)formation; NgR1 (show NEUROG1 Antibodies) is LOTUS-binding protein;LOTUS suppressed Nogo (show RTN4 Antibodies)-NgR1 (show NEUROG1 Antibodies) binding and Nogo (show RTN4 Antibodies)-induced growth cone collapse;suggest endogenous antagonism of NgR1 (show NEUROG1 Antibodies) by LOTUS crucial for LOT formation
This gene encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture. The presence of FG-GAP motifs and an RGD integrin-binding motif suggests that this protein may be involved in cell-cell or cell-matrix interactions. Copy number alterations in this gene have been observed in neurofibromatosis type 1-associated glomus tumors. Alternative splicing results in multiple transcript variants.
cartilage acidic protein 1
, cartilage acidic protein 1a
, acidic secreted protein in cartilage
, chondrocyte expressed protein 68 kDa CEP-68
, 68 kDa chondrocyte-expressed protein
, protein CRTAC1-B