anti-Caspase Recruitment Domain Family, Member 14 (CARD14) Antibodies

CARD14 encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Additionally we are shipping CARD14 Proteins (6) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CARD14 79092 Q9BXL6
CARD14 170720 Q99KF0
CARD14 688292  
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Top anti-CARD14 Antibodies at

Showing 10 out of 59 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of CARD14 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of CARD14 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 13 to 14 Days
Human Rabbit Un-conjugated IHC, IHC (p) Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-CARD14 / CARMA2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 0.05 mg Log in to see 11 to 14 Days
Human Mouse Un-conjugated WB Western Blot analysis of CARD14 expression in transfected 293T cell line by CARD14 MaxPab polyclonal antibody.Lane 1: CARD14 transfected lysate(47.74 KDa).Lane 2: Non-transfected lysate. 50 μL Log in to see 11 to 12 Days
Human Rabbit Un-conjugated ELISA, IHC Immunohistochemistry analysis of CARD14 in human placenta tissue with CARD14 polyclonal antibody  at 5 ug/mL. 100 μg Log in to see 11 to 12 Days
Human Rabbit Un-conjugated EIA, IHC (p)   0.1 mg Log in to see 4 to 8 Days
Human Rabbit Un-conjugated ELISA, IF, IHC   100 μL Log in to see Available
Human Rabbit Un-conjugated ELISA, IF, IHC, IHC (p)   100 μL Log in to see 11 to 14 Days
Human Chicken Un-conjugated WB 0.05 mg Log in to see 2 to 3 Days
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged CARD14 is approximately 0.1ng/ml as a capture antibody. 100 μg Log in to see 11 to 12 Days
Human Rabbit Un-conjugated IHC, ELISA 0.1 mg Log in to see 2 to 3 Days

Top referenced anti-CARD14 Antibodies

  1. Human Polyclonal CARD14 Primary Antibody for WB - ABIN528893 : Huh, Kim, Kim, Song, Jung, Jeong, Lee, Kim, Lee, An: Dysregulation of miR-106a and miR-591 confers paclitaxel resistance to ovarian cancer. in British journal of cancer 2013 (PubMed)

More Antibodies against CARD14 Interaction Partners

Human Caspase Recruitment Domain Family, Member 14 (CARD14) interaction partners

  1. CARD14 mutations are independently associated with psoriasis and familial PRP, providing a pathophysiologic link between these disorders. The subjects in this series provide striking clinical evidence for this connection and display findings characteristic of both PRP and psoriasis.

  2. Results identified RNF7 to interact with CARMA2 regulating its NF-kappaB-activating capacity. Mechanistically, RNF7 influences CARMA2 signaling by regulating the ubiquitination state of MALT1 and the NF-kappaB-regulatory molecule NEMO. Interestingly, CARMA2short (CARMA2sh) mutants associated with psoriasis susceptibility escape the negative control exerted by RNF7.

  3. The serine/threonine kinase ULK2 binds to and phosphorylates CARMA2sh.

  4. MALT1 deficiency or pharmacological inhibition of MALT1 catalytic activity inhibits pathogenic mutant CARD14-induced cytokine and chemokine expression in human primary keratinocytes.

  5. CARD14/MALT1-mediated signaling in keratinocytes has a role in psoriasis [review]

  6. The results indicate that the common CARD14 p.Arg820Trp variant might have a significant effect on the response to anti-TNF therapies among patients with psoriasis. In addition, rare CARD14 missense variants could also predispose to a better response.

  7. Our findings, combined with the published literature, suggest that Pityriasis Rubra Pilaris Type V, both familial and sporadic, can be caused by CARD14 mutations.

  8. Psoriasis mutations disrupt CARD14 autoinhibition promoting BCL10-MALT1-dependent NF-kappaB activation

  9. genetic evidence suggests association of the CARD14 single nucleotide polymorphism rs11652075 and other rare mutations in this gene with psoriasis. To assess whether combined data support the relationship between CARD14 rs11652075 and susceptibility to this disease, we conducted a meta-analysis. Our results demonstrate a significant association between the CARD14 rs11652075 polymorphism and psoriasis.

  10. SNP c.C2458T may have significant effects on heritability of psoriasis vulgaris in our Chinese population. The CC genotype was more common in familial cases than in sporadic cases.

  11. The authors observations provide further insights into the genetics of psoriasis and functional information on novel CARD14 mutational variants seen in cases from Tunisia and other populations.

  12. Genetic interactions of SNPs in CARD14, SENP1 and VEGFA might represent a functional mechanism in the pathogenesis of high altitude polycythemia.

  13. We found five rare mutations and four of them are annotated or reported. Only the variant (c.1291C>G) has not been reported and annotated, but the variant was also found in controls. None of the new definite variants were pathogenic

  14. analysis of 105 individuals with generalized pustular psoriasis (GPP) identified a low-frequency variant (p.Asp176His) that causes constitutive CARD14 oligomerization

  15. CARD14 protein missense mutation found in patients diagnosed with psoriasis.

  16. no definite causative genetic mutation in CARD14 as identified in familial pityriasis rubra pilaris after screening 8 non-familial patients of type I, type III and type IV pityriasis rubra pilaris

  17. The study identified the DEP domain-containing protein DEPDC7 as cellular binding partner of CARMA2 and CARMA3 proteins.

  18. CARD14 mutation maybe responsible for activation of NF-kB signaling pathway in patients with pityriasis rubra pilaris.

  19. Transfection of dermal ECs with psoriasis-associated CARD14 mutations resulted in increased expression of several chemokines, including CXCL10, IL-8, and CCL2.

  20. Variant analysis of CARD14 in a Chinese Han population with psoriasis vulgaris and generalized pustular psoriasis shows that CARD14 may play a role in the pathogenesis of generalized pustular psoriasis.

Mouse (Murine) Caspase Recruitment Domain Family, Member 14 (CARD14) interaction partners

  1. Caspase recruitment domain family member 14 (Card14)(E138A/+) and Card14(DeltaQ136/+) mice develop spontaneous psoriasis-like skin inflammation, resulted from constitutively activated CARMA2 via self-aggregation leading to the enhanced activation of the IL-23-IL-17A cytokine axis. Card14(-/-) mice display attenuated skin inflammation in the imiquimod-induced psoriasis model due to impaired IL-17A signaling in keratinoc...

  2. in experimental models of psoriasis induced by either imiquimod cream or recombinant IL-23 injection, the psoriasiform skin inflammation was abrogated in Card14(-/-) mice

CARD14 Antigen Profile

Protein Summary

This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with CARD14

  • caspase recruitment domain family member 14 (CARD14) antibody
  • caspase recruitment domain family, member 14 (Card14) antibody
  • caspase recruitment domain family member 14 (Card14) antibody
  • Bimp2 antibody
  • CARMA2 antibody
  • PRP antibody
  • PSORS2 antibody
  • PSS1 antibody

Protein level used designations for CARD14

CARD-containing MAGUK protein 2 , bcl10-interacting maguk protein 2 , card-maguk protein 2 , carma 2 , caspase recruitment domain-containing protein 14 , bcl10-interacting MAGUK protein 2

79092 Homo sapiens
170720 Mus musculus
688292 Rattus norvegicus
100733298 Cavia porcellus
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