anti-Cation Channel, Sperm Associated 1 (CATSPER1) Antibodies

Horse (Equine) Cation Channel, Sperm Associated 1 (CATSPER1) interaction partners

1. The CatSper channel is present in equine sperm but that the relationship of hyperactivated motility to calcium influx is weak.

Human Cation Channel, Sperm Associated 1 (CATSPER1) interaction partners

1. explored whether steroid hormones to which human spermatozoa are exposed in the male and female genital tract influence CatSper activation via modulation of ABHD2 (show ABHD2 Antibodies)

2. Electrophysiological studies showed a significant increase in Cd(2 (show CD2 Antibodies)+) and manganese (Mn(2+)) currents through the CaV3.1 (show CACNA1G Antibodies) mutants as well as a reduction in the inhibitory effect of Cd(2 (show CD2 Antibodies)+) on the Ca(2 (show CA2 Antibodies)+) current.

3. Sperm with a near absence of CatSper current failed to respond to activation of CatSper by progesterone and there was fertilization failure at IVF (show SCN5A Antibodies).

4. The role of CATSPER1 in idiopathic asthenospermia pathogenesis: exonal SNP rs1893316 in CATSPER1 significantly correlated with idiopathic asthenospermia risk

5. Sox5 (show SOX5 Antibodies) and Sox9 (show SOX9 Antibodies) cause a significant increase in transactivation of the Catsper1 promoter.

6. Progesterone via CatSper activates the PI3K (show PIK3CA Antibodies)-AKT (show AKT1 Antibodies) pathway required for motility and hyperactivation but not for acrosome reaction.

7. This work reports the cloning and characterization of the promoter regions in the human and murine Catsper1 genes. The immediate upstream region and the first exon in the human CATSPER1 gene negatively regulate transcriptional activity. The mouse Catsper1 promoter exhibited transcriptional activity in both orientations and displayed significant expression levels in mouse testis in vivo.

8. CatSper is indeed the principal Ca2 (show CA2 Antibodies)+ channel of human spermatozoa, and that it is strongly potentiated by progesterone.

9. CatSper activation can elicit functionally different behaviors according to the sensitivity of the Ca(2 (show CA2 Antibodies)+) store, which may be regulated by capacitation and NO from the cumulus.

10. It was shown that odorants directly activate CatSper without involving G protein-coupled receptors and cAMP. Membrane-permeable analogues of cyclic nucleotides activated CatSper directly via an extracellular site.

Mouse (Murine) Cation Channel, Sperm Associated 1 (CATSPER1) interaction partners

1. Both in vivo administration and in vitro application of bisphenol A impair mature sperm functions by a CatSper-relevant mechanism.

2. patch clamping of sperm revealed that CRISP1 (show CRISP1 Antibodies) has the ability to regulate CatSper, the principal sperm Ca(2 (show CA2 Antibodies)+) channel involved in hyperactivation and essential for fertility

3. Catsper transports the Ca(2 (show CA2 Antibodies)+) involved in the regulation of cAMP-dependent and tyrosine phosphorylation pathways required for sperm capacitation.

4. These results establish a critical role of LRRC52 in KSPER channels and demonstrate that loss of a non-pore-forming auxiliary subunit results in severe fertility impairment.

5. SLO3 (show KCNU1 Antibodies) K+ channels have a role in controlling calcium entry through CATSPER channels in sperm

6. Using mice lacking both SLO3 (show KCNU1 Antibodies) and CATSPER1 subunits, the results show conclusively that the voltage-activated outward current present in Slo3 (show KCNU1 Antibodies) (-/-) sperm is abolished when CATSPER is also deleted.

7. The mouse Catsper1 promoter exhibited transcriptional activity in both orientations and displayed significant expression levels in the mouse testis in vivo.

8. Immunization with B-cell epitopes in transmembrane domains and pore region of CatSper1 can cause significant antifertility effects in male mice.

9. Yijingfang can increase the sperm count and the expression of CatSper1.

10. KSper/Slo3 (show KCNU1 Antibodies) is the primary spermatozoan K(+) channel (show KCNC4 Antibodies),and KSper may play a critical role in acquisition of normal morphology and sperm motility when faced with hyperosmotic challenges.