anti-Cation Channel, Sperm Associated 1 (CATSPER1) Antibodies

Calcium ions play a primary role in the regulation of sperm motility. Additionally we are shipping CATSPER1 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CATSPER1 117144 Q8NEC5
CATSPER1 225865 Q91ZR5
CATSPER1 689349  
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Top anti-CATSPER1 Antibodies at antibodies-online.com

Showing 10 out of 29 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB CATSPER1 Antibody (N-term) western blot analysis in HepG2 cell line lysates (35µg/lane).This demonstrates the CATSPER1 antibody detected the CATSPER1 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of CATSPER1 expression in MCF7 (A), NS-1 (B), PC12 (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated WB CATSPER1 Antibody (N-term) (ABIN656919) western blot analysis in HepG2 cell line lysates (35 µg/lane). This demonstrates the CATSPER1 antibody detected the CATSPER1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of CATSPER1 using K562 whole cell lysates 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 11 to 14 Days
$375.83
Details
Human Rabbit Un-conjugated ELISA, WB   200 μL Log in to see 11 to 16 Days
$658.43
Details
Human Rabbit Biotin ELISA, WB   200 μL Log in to see 11 to 14 Days
$1,013.83
Details
Human Rabbit FITC ELISA, WB   200 μL Log in to see 11 to 14 Days
$1,013.83
Details
Human Rabbit HRP ELISA, WB   200 μL Log in to see 11 to 14 Days
$1,013.83
Details
Human Rabbit APC ELISA, WB   200 μL Log in to see 11 to 14 Days
$1,013.83
Details

More Antibodies against CATSPER1 Interaction Partners

Horse (Equine) Cation Channel, Sperm Associated 1 (CATSPER1) interaction partners

  1. The CatSper channel is present in equine sperm but that the relationship of hyperactivated motility to calcium influx is weak.

Human Cation Channel, Sperm Associated 1 (CATSPER1) interaction partners

  1. results show that the transcriptional factor SRY specifically binds to different sites in the promoter sequence and has the ability to control CATSPER1 gene transcription.

  2. explored whether steroid hormones to which human spermatozoa are exposed in the male and female genital tract influence CatSper activation via modulation of ABHD2

  3. Electrophysiological studies showed a significant increase in Cd(2+) and manganese (Mn(2+)) currents through the CaV3.1 mutants as well as a reduction in the inhibitory effect of Cd(2+) on the Ca(2+) current.

  4. Sperm with a near absence of CatSper current failed to respond to activation of CatSper by progesterone and there was fertilization failure at IVF.

  5. The role of CATSPER1 in idiopathic asthenospermia pathogenesis: exonal SNP rs1893316 in CATSPER1 significantly correlated with idiopathic asthenospermia risk

  6. Sox5 and Sox9 cause a significant increase in transactivation of the Catsper1 promoter.

  7. Progesterone via CatSper activates the PI3K-AKT pathway required for motility and hyperactivation but not for acrosome reaction.

  8. This work reports the cloning and characterization of the promoter regions in the human and murine Catsper1 genes. The immediate upstream region and the first exon in the human CATSPER1 gene negatively regulate transcriptional activity. The mouse Catsper1 promoter exhibited transcriptional activity in both orientations and displayed significant expression levels in mouse testis in vivo.

  9. CatSper is indeed the principal Ca2+ channel of human spermatozoa, and that it is strongly potentiated by progesterone.

  10. CatSper activation can elicit functionally different behaviors according to the sensitivity of the Ca(2+) store, which may be regulated by capacitation and NO from the cumulus.

  11. It was shown that odorants directly activate CatSper without involving G protein-coupled receptors and cAMP. Membrane-permeable analogues of cyclic nucleotides activated CatSper directly via an extracellular site.

  12. The decreased or abnormal expression of the CatSper1 protein may be a factor involved in the pathogenesis of idiopathic asthenozoospermia.

  13. progesterone activates the sperm-specific, pH-sensitive CatSper Ca(2+) channel

  14. human CatSper is synergistically activated by elevation of intracellular pH and extracellular progesterone

  15. Studies indicate that CATSPER channel represents a novel human male fertility factor.

  16. Potential role for CatSper in sperm motility and fertility in mouse and human. CatSper is therefore implicated as a potential target to explore the molecular mechanisms of male infertility.

  17. CATSPER1 is meiotically and post-meiotically expressed in human testis tissue.

  18. CatSper1 and CatSper2 can associate with and modulate the function of the Ca(v)3.3 channel, which might be important in the regulation of sperm function.

  19. CatSper1 may be a potential target for immunocontraception, and the antibody may be a tool to study the function of ion channels in sperm.

Mouse (Murine) Cation Channel, Sperm Associated 1 (CATSPER1) interaction partners

  1. The results showed that hypothyroidism could adversely affect sperm morphology, sperm chromatin condensation, and CatSper gene expression in mice and these abnormalities may be related to the excessive production of reactive oxygen species (ROS) in a hypothyroid state.

  2. Data suggest that Catsper1, Catsper2, Catsper3, and Catsper4 form protein multimer with hypothetical activities of flippase and disulfide isomerase.

  3. Both in vivo administration and in vitro application of bisphenol A impair mature sperm functions by a CatSper-relevant mechanism.

  4. patch clamping of sperm revealed that CRISP1 has the ability to regulate CatSper, the principal sperm Ca(2+) channel involved in hyperactivation and essential for fertility

  5. Catsper transports the Ca(2+) involved in the regulation of cAMP-dependent and tyrosine phosphorylation pathways required for sperm capacitation.

  6. These results establish a critical role of LRRC52 in KSPER channels and demonstrate that loss of a non-pore-forming auxiliary subunit results in severe fertility impairment.

  7. SLO3 K+ channels have a role in controlling calcium entry through CATSPER channels in sperm

  8. Using mice lacking both SLO3 and CATSPER1 subunits, the results show conclusively that the voltage-activated outward current present in Slo3 (-/-) sperm is abolished when CATSPER is also deleted.

  9. The mouse Catsper1 promoter exhibited transcriptional activity in both orientations and displayed significant expression levels in the mouse testis in vivo.

  10. Immunization with B-cell epitopes in transmembrane domains and pore region of CatSper1 can cause significant antifertility effects in male mice.

  11. Yijingfang can increase the sperm count and the expression of CatSper1.

  12. KSper/Slo3 is the primary spermatozoan K(+) channel,and KSper may play a critical role in acquisition of normal morphology and sperm motility when faced with hyperosmotic challenges.

  13. The initial phase of the increases in intracellular calcium concentration induced by BSA requires the CATSPER channel, but not the voltage-gated calcium channel.

  14. CatSper1 functions as a voltage-gated Ca2+ channel that controls Ca2+ entry to mediate the hyperactivated motility needed late in the preparation of sperm for fertilization

  15. Potential role for CatSper in sperm motility and fertility in mouse and human. CatSper is therefore implicated as a potential target to explore the molecular mechanisms of male infertility.

  16. Catsper1's function in sperm physiology and role in sperm competition using rodent models

  17. CatSper1 and CatSper2 null sperm show identical phenotypes in mice

  18. results identify CatSper1 as a component of the key flagellar calcium channel, and suggest that intracellular alkalinization potentiates CatSper current to increase intraflagellar calcium and induce sperm hyperactivation

  19. Direct protein interactions among CatSpers, the sperm specificity of these proteins, and loss of ICatSper in each of the four CatSper-/- mice indicate that CatSpers are highly specialized flagellar proteins

  20. Data show that there is a significant downregulation of CatSpers 1 following spinal cord injury.

CATSPER1 Antigen Profile

Protein Summary

Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region.

Gene names and symbols associated with CATSPER1

  • cation channel sperm associated 1 (CATSPER1) antibody
  • cation channel sperm-associated protein 1 (LOC100448226) antibody
  • cation channel, sperm associated 1 (Catsper1) antibody
  • Catsper antibody
  • KSper antibody
  • SPGF7 antibody

Protein level used designations for CATSPER1

cation channel, sperm associated 1 , cation channel sperm-associated protein 1 , hCatSper , sperm ion channel , sperm-associated cation channel 1 , cation channel of sperm 1 , sperm protein CATSPER1

GENE ID SPECIES
476016 Canis lupus familiaris
523556 Bos taurus
721869 Macaca mulatta
100058005 Equus caballus
100392349 Callithrix jacchus
100448226 Pongo abelii
100595887 Nomascus leucogenys
117144 Homo sapiens
225865 Mus musculus
689349 Rattus norvegicus
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