Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase ELISA Kits

CBLB encodes a protein that catalyzes the final step in the conversion of vitamin B(12) into adenosylcobalamin (AdoCbl), a vitamin B12-containing coenzyme for methylmalonyl-CoA mutase.

Data Quality
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Type
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    Kit
Antigen
  • 7
Reactivity
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  • 2
  • 1
Application
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Method Type
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Analytical Method
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Detection Method
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Plate
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7 Products
Pre-coated, Samples: Plasma, Serum, Tissue Homogenate
ReactivityHuman
Detection MethodColorimetric, Sandwich ELISA
Detection Range78 pg/mL - 5000 pg/mL
Order details Cat. No. ABIN5519661
$641.23
96 tests
Plus shipping costs $45.00
Delivery in 13 to 16 Business Days
ReactivityRat (Rattus)
Detection MethodColorimetric, Sandwich ELISA
Detection RangeQuantitative
Order details Cat. No. ABIN6200984
$612.03
96 tests
Plus shipping costs $45.00
Delivery in 11 to 18 Business Days
Pre-coated, Samples: Plasma, Serum, Tissue Homogenate
ReactivityHuman
Detection MethodColorimetric, Sandwich ELISA
Detection Range78-5000 pg/mL
Order details Cat. No. ABIN5591508
$713.90
96 tests
Plus shipping costs $45.00
Delivery in 6 to 8 Business Days
Samples: Plasma, Serum, Tissue Homogenate
ReactivityHuman
Detection MethodColorimetric, Sandwich ELISA
Order details Cat. No. ABIN5073182
$850.14
Plus shipping costs $45.00
Delivery in 16 to 21 Business Days
ReactivityMouse (Murine)
Detection MethodColorimetric,
Order details Cat. No. ABIN1131076
$875.60
96 tests
Plus shipping costs $45.00
Delivery in 15 to 18 Business Days
ReactivityHuman
Detection MethodColorimetric,
Detection Range78-5000 pg/mL
Order details Cat. No. ABIN1131075
$875.60
96 tests
Plus shipping costs $45.00
Delivery in 15 to 18 Business Days
ReactivityRat (Rattus)
Detection MethodColorimetric,
Order details Cat. No. ABIN1131077
$875.60
96 tests
Plus shipping costs $45.00
Delivery in 15 to 18 Business Days
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Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) Antigen Profile

Protein Summary

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B- cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T- cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. {ECO:0000269|PubMed:10646608, ECO:0000269|PubMed:10646609, ECO:0000269|PubMed:11070165, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:12771181, ECO:0000269|PubMed:15308098}.

Gene names and symbols associated with CBLB

  • Cbl proto-oncogene B, E3 ubiquitin protein ligase L homeolog (cblb.L) antibody
  • Casitas B-lineage lymphoma b (Cblb) antibody
  • Cbl proto-oncogene B (Cblb) antibody
  • Cbl proto-oncogene B (CBLB) antibody
  • AI429560 antibody
  • AI851073 antibody
  • Cbl-b antibody
  • cblb antibody
  • rnf56 antibody

Protein level used designations for CBLB

Cas-Br-M (murine) ecotropic retroviral transforming sequence b , Cbl proto-oncogene, E3 ubiquitin protein ligase B , E3 ubiquitin-protein ligase CBL-B-A , SH3-binding protein CBL-B-A , signal transduction protein CBL-B-A , Casitas B-lineage lymphoma proto-oncogene b , E3 ubiquitin-protein ligase CBL-B , RING-type E3 ubiquitin transferase CBL-B , SH3-binding protein CBL-B , Signal transduction protein CBL-B , casitas B-lineage lymphoma proto-oncogene b , signal transduction protein CBL-B , Cas-Br-M (murine) ectropic retroviral transforming sequence b , Casitas B-lineage lymphoma b , Cbl proto-oncogene B, E3 ubiquitin protein ligase , LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL-B , Cas-Br-M ecotropic retroviral transforming sequence b

GENE ID SPECIES
443854 Xenopus laevis
208650 Mus musculus
171136 Rattus norvegicus
100718857 Cavia porcellus
100621690 Sus scrofa
100355469 Oryctolagus cuniculus
525906 Bos taurus
100061819 Equus caballus
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