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Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Proteins

CBLB encodes a protein that catalyzes the final step in the conversion of vitamin B(12) into adenosylcobalamin (AdoCbl), a vitamin B12-containing coenzyme for methylmalonyl-CoA mutase.

7 results:

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 1-982) protein (His tag) Protein

CBLB Origin: Human Source: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
Catalog No. ABIN3090503
$13,376.85
Plus shipping costs $45.00 and $22.00 dry ice
1 mg (More quantities available)
local_shipping Shipping to: United States
Will be delivered in 70 Business Days

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 1-982) protein (His tag) Protein

CBLB Origin: Mouse Source: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
Catalog No. ABIN3134985
$13,376.85
Plus shipping costs $45.00 and $22.00 dry ice
1 mg (More quantities available)
local_shipping Shipping to: United States
Will be delivered in 70 Business Days

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 1-982) protein (GST tag) Protein

CBLB Origin: Human Source: Wheat germ Recombinant AA, AP, ELISA, WB
Pubmed 1
Catalog No. ABIN1348172
$230.67
Plus shipping costs $45.00 and $22.00 dry ice
2 μg
local_shipping Shipping to: United States
Delivery in 11 to 12 Business Days

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 21-129) protein (GST tag) Protein

CBLB Origin: Human Source: Wheat germ Recombinant AA, AP, ELISA, WB
Catalog No. ABIN1348174
$340.00
Plus shipping costs $45.00 and $22.00 dry ice
10 μg (More quantities available)
local_shipping Shipping to: United States
Delivery in 11 to 12 Business Days

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) protein (Myc-DYKDDDDK Tag) Protein

CBLB Origin: Human Source: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, Func, PI, STD
Catalog No. ABIN2713255
$888.80
Plus shipping costs $45.00 and $22.00 dry ice
20 μg
local_shipping Shipping to: United States
Will be delivered in 11 Business Days

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 39-426) protein (His tag) Protein

CBLB Origin: Human Source: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE.
Catalog No. ABIN6938865
$385.00
Plus shipping costs $45.00
100 μg (More quantities available)
local_shipping Shipping to: United States
Will be delivered in 5 Business Days

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 39-426) protein (AVI tag,Biotin,His tag) Protein

CBLB Origin: Human Source: Escherichia coli (E. coli) Recombinant >90 % as determined by reduced SDS-PAGE.
Catalog No. ABIN5674586
$1,320.00
Plus shipping costs $45.00
200 μg (More quantities available)
local_shipping Shipping to: United States
Will be delivered in 5 Business Days
  • Type Protein
    • Protein
  • Target Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB)
    • Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB)
    • Hemagglutinin (HA)
    • Ribosome Binding Factor A (RBFA)
    • Tumor Necrosis Factor alpha (TNF)
    • S-Adenosyl-Methionine Synthase (METK)
    • Interleukin 6 (IL6)
    • Interferon gamma (IFNG)
    • Hemoglobin beta (HBB)
    • Triosephosphate Isomerase 1 (TPI1)
    • Interleukin 4 (IL4)
    • Interleukin 1, beta (IL1B)
    • Thymidylate Kinase (Tmk)
    • Interleukin 2 (IL2)
    • Uracil-DNA Glycosylase (UNG)
    • Growth Hormone 1 (GH1)
    • Fibroblast Growth Factor 2 (Basic) (FGF2)
    • Lipoyl synthase lipA
    • Interleukin 10 (IL10)
    • KIT Ligand (KITLG)
    • Malate Dehydrogenase (MDH)
    • Leptin (LEP)
    • Epidermal Growth Factor (EGF)
    • Insulin-Like Growth Factor 1 (IGF1)
    • Interleukin 8 (IL8)
    • Vascular Endothelial Growth Factor A (VEGFA)
    • Interleukin 3 (IL-3)
    • Myoglobin (MB)
    • Queuine tRNA-Ribosyltransferase 1 (QTRT1)
    • Hemoglobin, alpha 1 (HBA1)
    • serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1)
    • phosphatidylserine Decarboxylase (PISD)
    • Interleukin 1 alpha (IL1A)
    • Prolactin (PRL)
    • Albumin (ALB)
    • Interleukin 13 (IL13)
    • CD40 Ligand (CD40LG)
    • Chemokine (C-X-C Motif) Ligand 12 (CXCL12)
    • Interleukin 15 (IL15)
    • beta-2-Microglobulin (B2M)
    • Aspartate Carbamoyltransferase (PYRB)
    • Phosphoglucosamine Mutase (GLMM)
    • Porphobilinogen Deaminase (HEMC)
    • Phenylalanyl-tRNA Synthetase, alpha Subunit (FARSA)
    • Chemokine (C-C Motif) Ligand 2 (CCL2)
    • Adiponectin (ADIPOQ)
    • Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2)
    • Gp120
    • Interleukin 33 (IL33)
    • Transforming Growth Factor, beta 1 (TGFB1)
    • Cytidine Monophosphate (UMP-CMP) Kinase 1, Cytosolic (CMPK1)
    • Fibroblast Growth Factor 1 (Acidic) (FGF1)
  • Application
    • ELISA
    • Western Blotting (WB)
    • Affinity Purification (AP)
    • Antibody Array (AA)
    • SDS-PAGE (SDS)
    • Crystallization (Crys)
    • Antibody Production (AbP)
    • Functional Studies (Func)
    • Protein Interaction (PI)
    • Standard (STD)
  • Reactivity
    • Human
    • Mouse
  • Cited in publications
  • Images available
  • Host
    • Escherichia coli (E. coli)
    • Insect Cells
    • Wheat germ
    • HEK-293 Cells
  • Binding Specificity
    • AA 1-982
    • AA 39-426
    • AA 21-129
  • Conjugate
    • Un-conjugated
    • His tag
    • GST tag
    • AVI tag,Biotin,His tag
    • Myc-DYKDDDDK Tag
  • Protein Type
    • Recombinant
  • Format
    • Liquid
    • Lyophilized

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) Protein Profile

Protein Summary

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B- cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T- cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. {ECO:0000269|PubMed:10646608, ECO:0000269|PubMed:10646609, ECO:0000269|PubMed:11070165, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:12771181, ECO:0000269|PubMed:15308098}.

Gene names and symbols associated with CBLB

  • Cbl proto-oncogene B, E3 ubiquitin protein ligase L homeolog (cblb.L) antibody
  • Casitas B-lineage lymphoma b (Cblb) antibody
  • Cbl proto-oncogene B (Cblb) antibody
  • Cbl proto-oncogene B (CBLB) antibody
  • AI429560 antibody
  • AI851073 antibody
  • Cbl-b antibody
  • cblb antibody
  • rnf56 antibody

Protein level used designations for CBLB

Cas-Br-M (murine) ecotropic retroviral transforming sequence b , Cbl proto-oncogene, E3 ubiquitin protein ligase B , E3 ubiquitin-protein ligase CBL-B-A , SH3-binding protein CBL-B-A , signal transduction protein CBL-B-A , Casitas B-lineage lymphoma proto-oncogene b , E3 ubiquitin-protein ligase CBL-B , RING-type E3 ubiquitin transferase CBL-B , SH3-binding protein CBL-B , Signal transduction protein CBL-B , casitas B-lineage lymphoma proto-oncogene b , signal transduction protein CBL-B , Cas-Br-M (murine) ectropic retroviral transforming sequence b , Casitas B-lineage lymphoma b , Cbl proto-oncogene B, E3 ubiquitin protein ligase , LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL-B , Cas-Br-M ecotropic retroviral transforming sequence b

GENE ID SPECIES
443854 Xenopus laevis
208650 Mus musculus
171136 Rattus norvegicus
100718857 Cavia porcellus
100621690 Sus scrofa
100355469 Oryctolagus cuniculus
525906 Bos taurus
100061819 Equus caballus
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