Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Proteins

CBLB encodes a protein that catalyzes the final step in the conversion of vitamin B(12) into adenosylcobalamin (AdoCbl), a vitamin B12-containing coenzyme for methylmalonyl-CoA mutase.

Data Quality
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Type
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    Protein
Antigen
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Reactivity
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  • 1
Application
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Host
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Binding Specificity
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Conjugate
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Protein Type
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Format
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7 Products
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityMouse (Murine)
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3134985
$13,376.85
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 70 Business Days
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityHuman
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3090503
$13,376.85
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 70 Business Days
ReactivityHuman
Application AA, AP, ELISA, WB
Order details Cat. No. ABIN1348172
$230.67
2 μg
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 11 to 12 Business Days
ReactivityHuman
Application AA, AP, ELISA, WB
Order details Cat. No. ABIN1348174
$340.00
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 11 to 12 Business Days
Recombinant Protein, HEK-293 Cells (Source), Purity > 80 % as determined by SDS-PAGE and Coomassie blue staining
ReactivityHuman
Application AbP, Func, PI, STD
Order details Cat. No. ABIN2713255
$888.80
20 μg
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 11 Business Days
Recombinant Protein, Escherichia coli (E. coli) (Source), Purity >95 % as determined by SDS-PAGE.
ReactivityHuman
Order details Cat. No. ABIN6938865
ISO
$385.00
Plus shipping costs $45.00
Will be delivered in 5 Business Days
Recombinant Protein, Escherichia coli (E. coli) (Source), Purity >90 % as determined by reduced SDS-PAGE.
ReactivityHuman
Order details Cat. No. ABIN5674586
ISO
$1,320.00
Plus shipping costs $45.00
Will be delivered in 5 Business Days
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Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) Protein Profile

Protein Summary

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B- cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T- cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. {ECO:0000269|PubMed:10646608, ECO:0000269|PubMed:10646609, ECO:0000269|PubMed:11070165, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:12771181, ECO:0000269|PubMed:15308098}.

Gene names and symbols associated with CBLB

  • Cbl proto-oncogene B, E3 ubiquitin protein ligase L homeolog (cblb.L) antibody
  • Casitas B-lineage lymphoma b (Cblb) antibody
  • Cbl proto-oncogene B (Cblb) antibody
  • Cbl proto-oncogene B (CBLB) antibody
  • AI429560 antibody
  • AI851073 antibody
  • Cbl-b antibody
  • cblb antibody
  • rnf56 antibody

Protein level used designations for CBLB

Cas-Br-M (murine) ecotropic retroviral transforming sequence b , Cbl proto-oncogene, E3 ubiquitin protein ligase B , E3 ubiquitin-protein ligase CBL-B-A , SH3-binding protein CBL-B-A , signal transduction protein CBL-B-A , Casitas B-lineage lymphoma proto-oncogene b , E3 ubiquitin-protein ligase CBL-B , RING-type E3 ubiquitin transferase CBL-B , SH3-binding protein CBL-B , Signal transduction protein CBL-B , casitas B-lineage lymphoma proto-oncogene b , signal transduction protein CBL-B , Cas-Br-M (murine) ectropic retroviral transforming sequence b , Casitas B-lineage lymphoma b , Cbl proto-oncogene B, E3 ubiquitin protein ligase , LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL-B , Cas-Br-M ecotropic retroviral transforming sequence b

GENE ID SPECIES
443854 Xenopus laevis
208650 Mus musculus
171136 Rattus norvegicus
100718857 Cavia porcellus
100621690 Sus scrofa
100355469 Oryctolagus cuniculus
525906 Bos taurus
100061819 Equus caballus
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