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CITED1 encodes a member of the CREB-binding protein/p300-interacting transactivator with Asp/Glu-rich C-terminal domain (CITED) family of proteins. Additionally we are shipping CITED1 Antibodies (59) and CITED1 Kits (12) and many more products for this protein.
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Forced nuclear enrichment of CITED1 in a human WT cell line appears to enhance tumorigenicity, whereas ectopic cytosolic expression confers stem-like properties and an embryonic phenotype.
Thus deficiency of Cited1 leads to hyper-activation of Wnt (show WNT2 Proteins) signaling and an exaggerated Wnt (show WNT2 Proteins) phenotype including elevated cell death
The CITED1 expression is correlated with lymph node metastasis in patients with colorectal cancer.
CITED1 expression remains active across all disease characteristics of Wilms tumor. It is found in the nucleus & cytosol. It is not found in normal kidney.
epigenetic regulation is involved in the overexpression of CITED1 in papillary thyroid cancer
TOX3 (show TOX3 Proteins) induces transcription in neuron depending on the presence of CITED1 or phosphorylated CREB (show CREB1 Proteins) in the transcriptionally active complex.
CITED1 functions as a cell cycle-dependent transcriptional cofactor whose activity is regulated by phosphorylation
CITED1 could play a role in Wilms' tumor initiation and pathogenesis.
Dicer (show DICER1 Proteins) ablation in the early metanephric mesenchyme results in severe renal dysgenesis despite normal initial specification of nephron progenitors and ureteric bud outgrowth.
The data indicated that serine phosphorylation at position 79 in the 63-84 domain is associated with PKC activation, and is required for both CITED1 nuclear translocation induced by PTH (show PTH Proteins)
Loss of placental Cited1 leads to intrauterine organ growth restriction with decreased IGF-I (show IGF1 Proteins) and IGF-II expression and in IR and Igf1r (show IGF1R Proteins) signaling.
CBP (show CREBBP Proteins) inactivation in mouse thymocytes leads to lymphoma
role for CITED1 in the modulation of transcriptional events mediated by steroid hormone and cytokine signaling pathways
The expression pattern of Cited2 (show CITED2 Proteins) overlaps that of Cited1, but its deletion, either alone or in combination with Cited1, does not disrupt epithelial differentiation of the metanephric mesenchyme.
These observations suggest that, in addition to an increased gene copy number and upregulation of EGR2 (show EGR2 Proteins) and CITED1, an elevated erbB2 (show ERBB2 Proteins) transcript level involves the loss of 14-3-3sigma, which sequesters a key transcriptional regulator of the erbB2 (show ERBB2 Proteins) promoter.
CITED1 negatively regulates osteoblastic differentiation in vitro and inhibits the cAMP-dependent stimulation of differentiation by intermittent PTH (show PTH Proteins).
Renal medullary dysplasia in Cited1 mutant mice is a direct consequence of decreased tissue oxygenation resulting from placental insufficiency.
This gene encodes a member of the CREB-binding protein/p300-interacting transactivator with Asp/Glu-rich C-terminal domain (CITED) family of proteins. The encoded protein, also known as melanocyte-specific gene 1, may function as a transcriptional coactivator and may play a role in pigmentation of melanocytes. Alternatively spliced transcript variants have been described.
Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1
, cbp/p300-interacting transactivator 1
, Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
, similar to Cbp/p300-interacting transactivator 1 (Melanocyte-specific protein 1)
, melanocyte-specific gene 1
, melanocyte-specific protein 1
, transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
, melanocyte-specific gene 1 protein