Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) ELISA Kits

human homolog may play a role in regulation of transcription and splicing [RGD, Feb 2006].. Additionally we are shipping Cdc2-Related Kinase, Arginine/serine-Rich Antibodies (46) and Cdc2-Related Kinase, Arginine/serine-Rich Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
CRKRS 51755 Q9NYV4
CRKRS 69131 Q14AX6
CRKRS 192350 Q3MJK5
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Top Cdc2-Related Kinase, Arginine/serine-Rich ELISA Kits at

Showing 4 out of 11 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 34 pg/mL 78-5000 pg/mL   96 Tests Log in to see 2 to 3 Days
Cow < 37 pg/mL 78 pg/mL - 5000 pg/mL   96 Tests Log in to see 11 to 18 Days
  96 Tests Log in to see 11 to 18 Days
  96 Tests Log in to see 11 to 18 Days

More ELISA Kits for Cdc2-Related Kinase, Arginine/serine-Rich Interaction Partners

Fruit Fly (Drosophila melanogaster) Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) interaction partners

  1. Cdk12 suppresses genes that support metabolic functions in stressed conditions. Cdk12 is not a generally essential Pol II kinase and is not required for the transcription of essential and housekeeping genes at least in adult tissues.

  2. CDK12 plays a role in controlling the epigenetic transition between euchromatin and heterochromatin, suggesting a chromatin regulatory mechanism in neuronal behaviors.

  3. The phosphorylation of the C-terminal domain of the RNA polymerase II by Cdk12 provides an elegant mechanism in regulating timed splicing of newly synthesized mRNA molecules.

Human Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) interaction partners

  1. CDK12 regulates prereplicative complex assembly to promote mammalian cell proliferation.

  2. CDK12 gene amplification can contribute to the pathogenesis of breast cancer.

  3. BRCA1 downregulation combined with CHK1 inhibition induced excessive amounts of DNA damage, resulting in an inability to complete the S-phase. Therefore, we suggest CHK1 inhibition as a strategy for targeting BRCA1- or CDK12-deficient tumors.

  4. In Ovarian Cancer patients CDK12 loss is consistently associated with a particular genomic instability pattern characterized by hundreds of tandem duplications

  5. Structures of CDK12/CycK complexes solved in the presence of AMP-PNP.

  6. Data show that most mutations prevent formation of the cyclin-dependent kinase 12 (Cdk12)/cyclin K (CycK) complex, rendering the kinase inactive.

  7. CDK12 affects RNA processing events in two distinct ways: Indirectly through generating factor-binding phospho-epitopes on the CTD of elongating RNAPII and directly through binding to specific factors

  8. CDK12 and CDK13 losses in HCT116 cells preferentially affect expression of DNA damage response.

  9. CDK12 plays an important role in cotranscriptional processing of c-FOS transcripts

  10. CDK12 has properties that should confirm interest in its use as a biomarker.

  11. many CDK12 mutations are an unrecognized cause of HR defects in ovarian cancers

  12. CDK12 interacts with cyclin K and is required to maintain embryonnic stem cell self-renewal.

  13. Cyclin K1 is the primary cyclin partner for CDK12/CrkRS and it is required for activation of CDK12/CrkRS to phosphorylate the C-terminal domain of RNA Pol II.

  14. through regulation of expression of DNA damage response genes, CycK/Cdk12 protects cells from genomic instability

  15. Data show that siRNA knockdown of hCDK12 in HeLa cells results in alterations in the CTD phosphorylation state.

  16. CRK7 modifies MAP kinases regulation and resistance to estrogen signaling inhibitors in breast cancers.

Mouse (Murine) Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) interaction partners

  1. Spontaneous DNA damage was revealed by an increase in 53BP1 foci among cells cultured from Cdk12(-/-) embryos.

  2. Report on the functions of Cdk12 during neural development in vivo, proposes a dual role for Cdk12 in neurogenesis and late stage neuronal migration via 2 distinct pathways

  3. The findings of this study suggest that Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression.

Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) Antigen Profile

Antigen Summary

human homolog may play a role in regulation of transcription and splicing

Gene names and symbols associated with CRKRS

  • Cyclin-dependent kinase 12 (Cdk12) antibody
  • cyclin dependent kinase 12 (CDK12) antibody
  • cyclin-dependent kinase 12 (Cdk12) antibody
  • 1810022J16Rik antibody
  • AC017581 antibody
  • AI646528 antibody
  • anon-WO0140519.165 antibody
  • cg7597 antibody
  • Crk7 antibody
  • CRKR antibody
  • Crkrs antibody
  • D11Ertd752e antibody
  • dCDK12 antibody
  • Dmel\\CG7597 antibody
  • gi24668141 antibody
  • hCDK12 antibody
  • Pksc antibody

Protein level used designations for CRKRS

CG7597-PA , CG7597-PB , CG7597-PC , Cdk12-PA , Cdk12-PB , Cdk12-PC , Cdc2-related kinase, arginine/serine-rich , CDC2-related protein kinase 7 , cell division cycle 2-related protein kinase 7 , cell division protein kinase 12 , CDC2-related kinase 7 , CDC2-related kinase, arginine/serine-rich , protein kinase for splicing component , cyclin-dependent kinase 12 isoform , cyclin-dependent kinase 12 , Cell division protein kinase 12

40385 Drosophila melanogaster
100354313 Oryctolagus cuniculus
51755 Homo sapiens
69131 Mus musculus
192350 Rattus norvegicus
511513 Bos taurus
100467815 Ailuropoda melanoleuca
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