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The protein encoded by CDC27 shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2.
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Human Monoclonal CDC27 Primary Antibody for IHC, ELISA - ABIN969035
Goto, Eddy: Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20. in The Journal of biological chemistry 2004
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Human Monoclonal CDC27 Primary Antibody for IHC, ELISA - ABIN965835
Koloteva-Levine, Pinchasi, Pereman, Zur, Brandeis, Elroy-Stein: The Apc5 subunit of the anaphase-promoting complex/cyclosome interacts with poly(A) binding protein and represses internal ribosome entry site-mediated translation. in Molecular and cellular biology 2004
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Human Polyclonal CDC27 Primary Antibody for ICC, IF - ABIN4296917
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
mir (show MLXIP Antibodies)-218-2 promotes glioblastomas growth, invasion and drug resistance by targeting CDC27 expression.
The levels of CDC20 (show CDC20 Antibodies) and CylinB1 increased and the levels of Ku70 (show XRCC6 Antibodies) and APC3 decreased after irradiation. APC (show APC Antibodies)/C(Cdh1 (show CDH1 Antibodies)) is involved in regulation of radiosensitivity in human NPC (show NPC1 Antibodies) CNE-1 cells.
Data indicate that UBE2S and APC3 co-regulate the expression level of P21 at G2/M check point via the ubiquitin-proteasome system.
Cdc27 is a novel binding partner of Elmo1 (show ELMO1 Antibodies).Cdc27-Elmo1 (show ELMO1 Antibodies) has a cellular role independent from the Elmo-Dock1 (show DOCK1 Antibodies)-Rac (show AKT1 Antibodies) signal module.
miR (show MLXIP Antibodies)-27a could modulate proliferation and radiosensitivity of TNBC cells. CDC-27 is a direct target of miR (show MLXIP Antibodies)-27a and its downregulation conferred increased radioresistance of the cells.
These findings suggested that polymorphisms in cdc27 may contribute to the susceptibility of BC though functional studies are needed to further elucidate the underling mechanisms of the associations
The structures show how one APC16 (show ANAPC16 Antibodies) binds asymmetrically to the symmetric APC3 dimer and, together with biochemistry and prior data, explain how APC16 (show ANAPC16 Antibodies) recruits APC7 (show ANAPC7 Antibodies) to APC3.
Low cdc27 and high securin (show PTTG1 Antibodies) expression predict short survival for breast cancer patients.
Down-regulation of CDC27 protein is associated with radiation resistance.
Data indicate that additional density present in the anaphase-promoting complex (APC (show APC Antibodies)/C) structure, proximal to Apc3/Cdc27 of the (tetratricopeptide repeat) lobe, is assigned to the TPR subunit Apc7 (show ANAPC7 Antibodies), a subunit specific to vertebrate APC (show APC Antibodies)/C.
Cdc27 directs cyclin D1 (show CCND1 Antibodies) to alternative degradation by anaphase promoting complex/cyclosome.
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, anaphase promoting complex subunit 3
, anaphase-promoting complex subunit 3
, anaphase-promoting complex, protein 3
, cell division cycle 27 homolog
, cell division cycle protein 27 homolog
, nuc2 homolog
, cell division cycle 27 homolog (S. cerevisiae)
, 20S cyclosome/APC complex protein apc3
, Nuclear alteration protein 2
, Nuclear scaffold-like protein p76
, cell division cycle protein 27