anti-Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) Antibodies

The protein encoded by CDC37 is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. Additionally we are shipping CDC37 Proteins (19) and CDC37 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CDC37 11140 Q16543
CDC37 12539 Q61081
CDC37 114562 Q63692
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Top anti-CDC37 Antibodies at antibodies-online.com

Showing 10 out of 185 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated ELISA, FACS, WB Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng) Western blot analysis using CDC37 mAb against human CDC37 (AA: 241-378) recombinant protein. (Expected MW is 41.6 kDa) 0.1 mg Log in to see 8 to 11 Days
$561.00
Details
Human Mouse Un-conjugated ELISA, WB Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng) Western blot analysis using CDC37 mAb against human CDC37 (AA: 241-378) recombinant protein. (Expected MW is 41.6 kDa) 0.1 mg Log in to see 8 to 11 Days
$561.00
Details
Human Rabbit Un-conjugated IC, IF, IP, IHC, WB Immunofluorescent analysis of CDC37 staining in K562 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of CDC37 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated WB Observed bind size: 44KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from HuvEc cells, using CDC37 (Phospho-Ser13) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human placenta, using CDC37 (Phospho-Ser13) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from MCF-7/COS7 cells, using CDC37 (Ab-13) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human placenta tissue, using CDC37 (Ab-13) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from NIH-3T3/HT-29/RAW264.7 cells, using p50 CDC37 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of CDC37 Antibody (Center) (ABIN652914) in MCF-7, A2058 cell line lysates (35 µg/lane). CDC37 (arrow) was detected using the purified polyclonal antibody. CDC37 Antibody (Center) (ABIN652914) IHC analysis in formalin fixed and paraffin embedded skin followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: CDC37 Antibody [NBP1-80960] - Staining of human duodenum shows moderate cytoplasmic positivity in glandular cells. Immunocytochemistry/Immunofluorescence: CDC37 Antibody [NBP1-80960] - Staining of human cell line A-431 shows positivity in cytoplasm. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Mouse Un-conjugated ELISA, FACS, IHC, WB ELISA: CDC37 Antibody (6B3B7)  - Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng) Flow Cytometry: CDC37 Antibody (6B3B7)  - Analysis of K562 cells using CDC37 mouse mAb (green) and negative control (red). 0.1 mL Log in to see 7 to 9 Days
$514.63
Details

Top referenced anti-CDC37 Antibodies

  1. Yeast (Saccharomyces cerevisiae) Polyclonal CDC37 Primary Antibody for IF, IP - ABIN2451938 : Reed: The selection of S. cerevisiae mutants defective in the start event of cell division. in Genetics 1981 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal CDC37 Primary Antibody for ICC, IF - ABIN4296941 : Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013 (PubMed)

More Antibodies against CDC37 Interaction Partners

Fruit Fly (Drosophila melanogaster) Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) interaction partners

Human Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) interaction partners

  1. Study showed that Cdc37 gene was up-regulated in human colorectal adenocarcinoma (CRC (show CALR Antibodies)). Furthermore, knockdown of Cdc37 effectively reduced cell proliferation activity, enhanced apoptosis, and inhibited G1-S transition in CRC (show CALR Antibodies) cells, and vice versa. For the mechanism, Cdc37 increased CDK4 (show CDK4 Antibodies) stability to promote the phosphorylation of RB1 (show RB1 Antibodies), which finally promoted the progression of CRC (show CALR Antibodies).

  2. During the kinase chaperone cycle, Cdc37 phosphorylated at Y298 acts as a platform for docking of non-receptor tyrosine kinases through their regulatory domains to drive the coupled Hsp90 (show HSP90 Antibodies) phosphorylation at Y197 and specifically regulate kinase chaperoning.

  3. findings suggested that this mechanism may be exploited by the Hsp90 (show HSP90 Antibodies)-Cdc37 chaperone to recruit and protect intrinsically dynamic kinase clients from degradation

  4. The results suggest a re-evaluation of the role of Cdc37 in the kinase lifecycle, and suggest that such interactions potentially allow kinases to more rapidly respond to key signals while simultaneously protecting unstable kinases from degradation and suppressing unwanted basal activity.

  5. Niclosamide ethanolamine disrupted the interaction between cell division cycle 37 and heat shock protein 90 (show HSP90 Antibodies) in hepatocellular carcinoma, reducing tumor growth.

  6. Cdc37 performs a quality control of protein kinases, including b-raf (show SNRPE Antibodies), where induced conformational instability acts as a "flag" for Hsp90 (show HSP90 Antibodies) dependence and stable cochaperone association.

  7. Ulk1 (show ULK1 Antibodies) promoted the degradation of Hsp90 (show HSP90 Antibodies)-Cdc37 client kinases, resulting in increased cellular sensitivity to Hsp90 (show HSP90 Antibodies) inhibitors. Thus, our study provides evidence for an anti-proliferative role of Ulk1 (show ULK1 Antibodies) in response to Hsp90 (show HSP90 Antibodies) inhibition in cancer cells

  8. The authors find that the interaction between sB-Raf (show RAF1 Antibodies) and the Hsp90 chaperone (show HSP90 Antibodies) system is based on contacts with the M domain of Hsp90 (show HSP90 Antibodies), which contributes in forming the ternary complex with Cdc37 as long as the kinase is not stabilized by nucleotide.

  9. Apart from these distinct Cdc37/Hsp90 interfaces, binding of the B-Raf protein kinase to the cochaperone is conserved between mammals and nematodes.

  10. Suppressing expression of the cochaperone CDC37 in hepatocellular carcinoma cells inhibits cell cycle progression and cell growth.

Mouse (Murine) Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) interaction partners

  1. Results showed that Cdc37 acts as a bridge to direct Hsp90 (show HSP90 Antibodies) to the transcription factor viral P proteins of all lyssaviruses. Although Cdc37 can load P proteins onto Hsp90 (show HSP90 Antibodies), with or without binding to Hsp90 (show HSP90 Antibodies), the interaction between Cdc37 and Hsp90 (show HSP90 Antibodies) appears to provide additional allosterical regulation of its chaperone activity. Notably, both phosphorylated and non-P Cdc37 could facilitate Hsp90 (show HSP90 Antibodies)-mediated protein maturation.

  2. Niclosamide ethanolamine disrupted the interaction between cell division cycle 37 and heat shock protein 90 (show HSP90 Antibodies) in hepatocellular carcinoma, reducing tumor growth.

  3. A series of tyrosine phosphorylation events, involving both p50(Cdc37) and Hsp90 (show HSP90 Antibodies), are minimally sufficient to provide directionality to the chaperone cycle.

  4. Hsp90 (show HSP90 Antibodies)-Cdc37 complex acta (show ACTC1 Antibodies) as an endogenous regulator of noncanonical p38alpha (show MAPK14 Antibodies) activity.

  5. CDC37 binds to Akt (show AKT1 Antibodies) and HSP90 (show HSP90 Antibodies) in the signal transduction pathway in human tumor cells

  6. The interaction between mouse Pem and Cdc37 homolog was then confirmed by glutathione S-transferase (show GSTa2 Antibodies) pull-down assay, and the possible interaction model was suggested.

  7. JAK1 (show JAK1 Antibodies)/2 are client proteins of Hsp90 alpha (show HSP90AA1 Antibodies) and beta; Hsp90 (show HSP90 Antibodies) and CDC37 play a critical role in types I and II interferon (show IFNA Antibodies) pathways

  8. This growth inhibition is partially rescued by expression of ectopic Gli1 (show GLI1 Antibodies), suggesting that Fu may contribute to enhance Hh signaling activity in cancer cells.

Cow (Bovine) Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) interaction partners

  1. Cdc37 has a direct regulatory interaction with endothelial nitric oxide synthase (eNOS (show NOS3 Antibodies)) and may play an important role in mediating the eNOS (show NOS3 Antibodies) protein complex formation.

CDC37 Antigen Profile

Protein Summary

The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases.

Gene names and symbols associated with CDC37

  • CG12019 gene product from transcript CG12019-RA (Cdc37) antibody
  • cell division cycle 37 homolog (Cdc37) antibody
  • Hsp90 co-chaperone Cdc37 (cdc37) antibody
  • Hsp90 co-chaperone Cdc37 (AFUA_4G10010) antibody
  • Cdc37p (CDC37) antibody
  • cell division cycle 37 (CDC37) antibody
  • cell division cycle 37 (Cdc37) antibody
  • Afu4g10010 antibody
  • cdc37 antibody
  • CG12019 antibody
  • CPDR-1 antibody
  • CPDR-2 antibody
  • Dmel\\CG12019 antibody
  • DROCPDR antibody
  • E(sev)3B antibody
  • p50 antibody
  • p50Cdc37 antibody

Protein level used designations for CDC37

CG12019-PA , Cdc37-PA , cdc37 protein , hsp90 co-chaperone Cdc37 , Hsp90 co-chaperone Cdc37 , hypothetical protein , CDC37 (cell division cycle 37, S. cerevisiae, homolog) , CDC37 cell division cycle 37 homolog , cell division cycle 37 homolog , hsp90 chaperone protein kinase-targeting subunit , CDC37 (cell division cycle 37 S. cerevisiae homolog) , p50Cdc37 , CDC37 cell division cycle 37 protein , CDC37 homolog , cell division cycle 37 protein , cell division cycle control protein 37

GENE ID SPECIES
38232 Drosophila melanogaster
724675 Apis mellifera
2541293 Schizosaccharomyces pombe 972h-
3509722 Aspergillus fumigatus Af293
3639210 Candida albicans SC5314
11140 Homo sapiens
12539 Mus musculus
114562 Rattus norvegicus
484955 Canis lupus familiaris
100141402 Sus scrofa
520883 Bos taurus
395430 Gallus gallus
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