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Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Additionally we are shipping Cell Division Cycle Associated 7-Like Antibodies (50) and Cell Division Cycle Associated 7-Like Kits (6) and many more products for this protein.
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Mouse JPO2/RAM2 (Cdca7l) interacts with cMyc (show MYC Proteins).
Suppression of CDCA7L limits multiple myeloma proliferation through apoptosis.
We identify the Myc (show MYC Proteins)-interacting protein JPO2 and its partner binding protein LEDGF/p75 (show PSIP1 Proteins) as critical modulators of PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling and metastasis in medulloblastoma
common LEDGF/p75 (show PSIP1 Proteins) interaction interface shared by JPO2, PogZ (show POGZ Proteins), MLL1, IWS1 and HIV IN
The data are consistent with the rs4487645-CDCA7L loci being responsible for the chromosome 7p11.2 association with multiple myeloma risk, probably exerting its effects through an extended pathway involving IRF4 (show IRF4 Proteins) and MYC (show MYC Proteins).
Data indicate that JPO2 and LEDGF/p75 (show PSIP1 Proteins) interact directly and specifically in vivo through the specific interaction domain of JPO2 and the C-terminal domain of LEDGF/p75 (show PSIP1 Proteins).
CDCA7L was able to activate the extracellular signal-regulated kinase 1/2 (show MAPK3 Proteins) (ERK1/2) signaling pathway and regulate the cell cycle, thus promoting HCC (show FAM126A Proteins) progression.
Reduction in R1 repressor protein correlates significantly with an increase (approximately 40%) in monoamine oxidase A (show MAOA Proteins) protein levels within the major depressive disorder groups compared with controls.
monoamine oxidase A (show MAOA Proteins) activation of glucocorticoids and androgens is regulated differently by R1 and Sp1 (show PSG1 Proteins)
demonstrates the functions of MAO A (show MAOA Proteins) and its repressor R1(RAM2/CDCA7L/JPO2) in apoptotic signaling pathways
Over-expression of JPO2 resulted in a modest but reproducible inhibition of HIV-1 replication, consistent with competition between integrase and JPO2 for binding to LEDGF/p75 (show PSIP1 Proteins)
Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Play an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways\; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1 (By similarity).
cell division cycle associated 7-like
, transcription factor RAM2
, cell division cycle-associated 7-like protein-like
, cell division cycle-associated 7-like protein
, Rap guanine nucleotide exchange factor (GEF) 5