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The protein encoded by CETN3 contains four EF-hand calcium binding domains, and is a member of the centrin protein family. Additionally we are shipping Centrin, EF-Hand Protein, 3 Proteins (11) and and many more products for this protein.
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Human Monoclonal CETN3 Primary Antibody for RNAi, ELISA - ABIN560341
Barr, Kilmartin, Gergely: CDK5RAP2 functions in centrosome to spindle pole attachment and DNA damage response. in The Journal of cell biology 2010
Show all 16 Pubmed References
Removal of CETN2 and CETN3 activity from the lumen of the connecting cilium (CC) destabilized the photoreceptor axoneme and reduced the CC length as early as postnatal day 22 (P22).
Cetn3 inhibits Mps1 autophosphorylation at Thr-676, a known site of T-loop autoactivation, and interferes with Mps1-dependent phosphorylation of Cetn2. The cellular overexpression of Cetn3 attenuates the incorporation of Cetn2 into centrioles and centrosome reduplication, whereas depletion of Cetn3 generates extra centrioles.
could be classified as a Ca(2+) sensor protein
The protein encoded by this gene contains four EF-hand calcium binding domains, and is a member of the centrin protein family. Centrins are evolutionarily conserved proteins similar to the CDC31 protein of S. cerevisiae. Yeast CDC31 is located at the centrosome of interphase and mitotic cells, where it plays a fundamental role in centrosome duplication and separation. Multiple forms of the proteins similar to the yeast centrin have been identified in human and other mammalian cells, some of which have been shown to be associated with centrosome fractions. This protein appears to be one of the most abundant centrins associated with centrosome, which suggests a similar function to its yeast counterpart.
centrin, EF-hand protein, 3 (CDC31 homolog)
, centrin 3
, centrin, EF-hand protein, 3 (CDC31 homolog, yeast)
, CDC31 yeast homolog
, EF-hand superfamily member