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Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. Additionally we are shipping CENPC1 Antibodies (66) and and many more products for this protein.
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Collectively, these studies clarify how CENP-N (show CENPN ELISA Kits) and CENP-C decode and stabilize the non-canonical CENP-A (show CENPA ELISA Kits) nucleosome to enforce epigenetic centromere specification and kinetochore assembly.
Levels of centromere aberrations increase upon depletion of CENP-A (show CENPA ELISA Kits), CENP-C, and CENP-T (show CENPT ELISA Kits)/W, during replicative senescence, and in cancer cells.
Upon cross-linking, the entire CENPA (show CENPA ELISA Kits)/CENPB (show CENPB ELISA Kits)/CENPC/CENPT (show CENPT ELISA Kits) complex is nuclease-protected over an alpha-satellite dimer that comprises the fundamental unit of centromeric chromatin. We conclude that CENPA/CENPC (show CENPA ELISA Kits) and CENPT (show CENPT ELISA Kits) pathways for kinetochore assembly are physically integrated over young alpha-satellite dimers.
Whereas CENP-C recruits a single MIS12:NDC80 (show NDC80 ELISA Kits) complex, the authors show here that CENP-T (show CENPT ELISA Kits) binds one MIS12:NDC80 (show NDC80 ELISA Kits) and two NDC80 (show NDC80 ELISA Kits) complexes upon phosphorylation by the mitotic CDK1 (show CDK1 ELISA Kits):Cyclin B complex at three distinct CENP-T (show CENPT ELISA Kits) sites.
CENP-C specifically binds alpha satellite non-coding RNAs.
CENP-C and CENP-I (show CENPI ELISA Kits) are key factors connecting kinetochore to CENP-A (show CENPA ELISA Kits) assembly.
A nonhistone centromere protein, CENP-C, binds and reshapes the nucleosome, sliding the DNA gyres back to positions similar to those in canonical nucleosomes containing conventional histone H3 (show HIST3H3 ELISA Kits).
HPV18 E7 inhibited the binding of CENP-C to alpha-satellite DNAs.
We used a synthetic system to dissect how CenH3(CENP-A (show CENPA ELISA Kits)) contributes to the accumulation of CENP-C and CENP-T (show CENPT ELISA Kits), two key components that are necessary for the formation of functional kinetochores
CENP-C recruits the Ndc80 complex through its interactions with KNL1 and the Mis12 complex at kinetochores during chromosome segregation.
Further investigation of the phosphoregulation of meiotic Kif4 revealed that Aurora Kinase and Cdk activity is critical for Kif4 kinetochore localization and interaction with Ndc80 and CENP-C. Finally, Kif4 protein but not gene expression was found to be upregulated with age, suggesting a role for this protein in the decline of oocyte quality with age
CENP-C works as an important factor for centromeric M18BP1 recruitment
Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12.
Centromere protein C 1
, CENP-C 1
, centromere autoantigen C
, centromere autoantigen C1
, centromere protein C 1
, interphase centromere complex protein 7
, centromere protein C1
, CENTROMERE PROTEIN C (CENP-C) (CENTROMERE AUTOANTIGEN C)