Centromere Protein W Proteins (CENPW)

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). Additionally we are shipping Centromere Protein W Antibodies (31) and Centromere Protein W Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CENPW 387103 Q5EE01
CENPW 66311 Q3URR0
CENPW 689399 A1L1L1
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Centromere Protein W Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$230.67
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,132.17
Details

CENPW Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Centromere Protein W (CENPW) Interaction Partners

Human Centromere Protein W (CENPW) interaction partners

  1. we suggest that STAT1HDAC4 signaling induces malignant tumor features such as EMT and sphere formation in CUG2overexpressing cancer cells.

  2. Report provides evidence that CUG2 induces the EMT in human lung cancer cells via enhancement of TGF-beta signaling and that that TGF-beta signaling is a potential target for CUG2-mediated oncogenesis.

  3. It has been proposed that CENP-W may function as a booster of beta-TrCP1 nuclear import to increase the oncogenicity of beta-TrCP1.

  4. FACT chaperone stabilizes the soluble CENP-T/-W complex in the cell and promotes dynamics of exchange, enabling CENP-T/-W deposition at centromeres.

  5. CENP-W interacts with hnRNPU and may contribute to kinetochore-microtubule attachment in mitotic cells.

  6. CENP-W is a novel kinetochore component that may be involved in the EZH2-mediated silencing machinery.

  7. We propose that CENP-W, by influencing proper kinetochore assembly, particularly microtubule docking sites, can confer spindle pole resistance to traction forces exerted by motor proteins during chromosome congression

  8. CUG2-mediated antiviral activity can be reduced by ISG15 deficiency in A549 cells, which eventually enhances sensitivity of the cells to vesicular stomatitis virus infection.

  9. our results suggest that CUG2 enhances metastasis and drug resistance through STAT1 activation, which eventually contributes to tumor progression

  10. CSN5 regulates the stability of the inner kinetochore components CENP-T and CENP-W, providing the first direct link between CSN5 and the mitotic apparatus, highlighting the role of CSN5 as a multifunctional cell cycle regulator.

  11. we propose that VSV treatment combined with the selective regulation of genes such as STAT1 and OASL2 will improve therapeutic outcomes for CUG2-overexpressing tumors.

  12. Single nucleotide polymorphism in CENPW is associated with the length of reproductive lifespan.

  13. B23 may function in the assembly of the kinetochore complex by interacting with CENP-W during interphase

  14. The CENP-T/W complex assembles through a dynamic exchange mechanism in late S-phase and G2, is required for mitosis in each cell cycle and does not persist across cell generations.

  15. Sp1 together with Sp3 may function as the main regulator of the basal and serum-induced transcription of CENP-W.

  16. Overexpression of CUG2 induces apoptosis in SKOV-3 cells.

  17. data indicate that activation of p38 MAPK and Ras has critical roles in reoviral replication in CUG2-expressing tumor cells.

  18. These findings suggest CUG2 is a novel tumor-associated gene that is commonly activated in various human cancers and exhibits high transforming activities; it possibly belongs to a transcription regulator family that is involved in tumor biogenesis.

  19. Study demonstrates that CENP-W forms a DNA-binding complex together with the CCAN component CENP-T; this complex directly associates with nucleosomal DNA and with canonical histone H3, but not with CENP-A, in centromeric regions.

  20. CUG2 is a new component of the human centromeric complex that is required for proper chromosome segregation during mitosis.

Mouse (Murine) Centromere Protein W (CENPW) interaction partners

  1. We determined that Poc1a, encoding protein of the centriole 1a, is disrupted by the insertion of a processed Cenpw cDNA, which is flanked by target site duplications, suggestive of a LINE-1 retrotransposon-mediated event

Centromere Protein W (CENPW) Protein Profile

Protein Summary

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis (By similarity).

Gene names and symbols associated with Centromere Protein W Proteins (CENPW)

  • centromere protein W (CENPW)
  • centromere protein W (Cenpw)
  • 2610036L11Rik protein
  • C6orf173 protein
  • CENP-W protein
  • Cug2 protein

Protein level used designations for Centromere Protein W Proteins (CENPW)

centromere protein W , CENP-W , cancer-up-regulated gene 2 protein , cancer-upregulated gene 2

GENE ID SPECIES
712570 Macaca mulatta
787125 Bos taurus
387103 Homo sapiens
66311 Mus musculus
689399 Rattus norvegicus
Selected quality suppliers for Centromere Protein W Proteins (CENPW)
Did you look for something else?