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Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity).
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Report provides evidence that CUG2 induces the EMT (show ITK Proteins) in human lung cancer cells via enhancement of TGF-beta (show TGFB1 Proteins) signaling and that that TGF-beta (show TGFB1 Proteins) signaling is a potential target for CUG2-mediated oncogenesis.
It has been proposed that CENP-W may function as a booster of beta-TrCP1 (show BTRC Proteins) nuclear import to increase the oncogenicity of beta-TrCP1 (show BTRC Proteins).
FACT chaperone stabilizes the soluble CENP-T (show CENPT Proteins)/-W complex in the cell and promotes dynamics of exchange, enabling CENP-T (show CENPT Proteins)/-W deposition at centromeres.
CENP-W interacts with hnRNPU (show HNRNPU Proteins) and may contribute to kinetochore-microtubule attachment in mitotic cells.
CENP-W is a novel kinetochore component that may be involved in the EZH2 (show EZH2 Proteins)-mediated silencing machinery.
We propose that CENP-W, by influencing proper kinetochore assembly, particularly microtubule docking sites, can confer spindle pole resistance to traction forces exerted by motor proteins during chromosome congression
CUG2-mediated antiviral activity can be reduced by ISG15 (show ISG15 Proteins) deficiency in A549 cells, which eventually enhances sensitivity of the cells to vesicular stomatitis virus infection.
our results suggest that CUG2 enhances metastasis and drug resistance through STAT1 (show STAT1 Proteins) activation, which eventually contributes to tumor progression
CSN5 regulates the stability of the inner kinetochore components CENP-T and CENP-W, providing the first direct link between CSN5 and the mitotic apparatus, highlighting the role of CSN5 as a multifunctional cell cycle regulator.
we propose that VSV treatment combined with the selective regulation of genes such as STAT1 (show STAT1 Proteins) and OASL2 will improve therapeutic outcomes for CUG2-overexpressing tumors.
We determined that Poc1a (show POC1A Proteins), encoding protein of the centriole 1a, is disrupted by the insertion of a processed Cenpw cDNA, which is flanked by target site duplications, suggestive of a LINE-1 retrotransposon-mediated event
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis (By similarity).
centromere protein W
, cancer-up-regulated gene 2 protein
, cancer-upregulated gene 2