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Plays a role in mitotic exit and cytokinesis.
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whole-exome sequencing lead to identification of a homozygous nonsense mutation c.256C>T (p.Arg86*) in CEP55 (centrosomal protein of 55 kDa) in autosomal recessive Meckel syndrome fetus.
CEP55 loss of function mutations likely underlie MARCH, a novel multiple congenital anomaly syndrome.
A FAK (show PTK2 Proteins)-Src (show SRC Proteins) signaling pathway downstream of integrin-mediated cell adhesion was found to decelerate both PLK1 degradation and CEP55 accumulation at the midbody. These data identify the regulation of PLK1 and CEP55 as steps where integrins exert control over the cytokinetic abscission.
Data suggest that USP9X as an integral component of centrosome where it functions to stabilize PCM1 and CEP55 and to promote centrosome biogenesis; N-terminal domain of USP9X appears to be responsible for physical association of USP9X with PCM1 and CEP55. (USP9X = ubiquitin-specific protease 9X; PCM1 = pericentriolar material 1 protein; CEP55 = 55kDa centrosomal protein)
Aberrant CEP55 expression may predict unfavorable clinical outcomes in epithelial ovarian carcinoma (EOC) patients and play an important role in regulating invasion in ovarian cancer cells. Thus, CEP55 may serve as a prognostic marker and therapeutic target for EOC
CEP55 plays a crucial role in promoting breast cancer cell proliferation and it might be a potential therapeutic target in breast cancer.
In depth discussion of the functions of CEP55 across different effector pathways, and also its roles as a biomarker and driver of tumorigenesis, commemorating a decade of research on CEP55. [review]
Which was required for FLJ10540/MMP-7 (show MMP7 Proteins) or FLJ10540/MMP-10 (show MMP10 Proteins) expressions.
myotubularin-related protein 3 (show MTMR3 Proteins) and myotubularin-related protein 4 may act as a bridge between CEP55 and polo-like kinase 1, ensuring proper CEP55 phosphorylation and regulating CEP55 recruitment to the midbody.
CEP55 mRNA/protein expression was observed is specific to TCC (show SFXN1 Proteins) of human urinary bladder and might be used as a diagnostic biomarker and vaccine target in development of BC specific immunotherapy.
Cep55 may act as an MTOC-associated protein regulating spindle organization, and thus cell cycle progression during mouse oocyte meiotic maturation.
The results suggest that Cep55 and pericentrin are required for the stable bridge between germ cells during spermatogenesis and spermiogenesis.
TEX14 (show TEX14 Proteins) prevents the completion of cytokinesis by altering the destiny of CEP55 from a nidus for abscission to an integral component of the intercellular bridge.
Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis (By similarity).
cancer/testis antigen 111
, centrosomal protein of 55 kDa
, up-regulated in colon cancer 6
, centrosomal protein 55kDa
, hypothetical protein
, centrosomal protein of 55 kDa-like