anti-Ceramide Synthase 6 (CERS6) Antibodies

May be involved in sphingolipid synthesis or its regulation (By similarity).. Additionally we are shipping Ceramide Synthase 6 Proteins (7) and Ceramide Synthase 6 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CERS6 253782 Q6ZMG9
CERS6 241447 Q8C172
CERS6 366065  
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Top anti-Ceramide Synthase 6 Antibodies at antibodies-online.com

Showing 10 out of 55 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-LASS6 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:12500  Positive Control:  COLO205 cell lysate CERS6 is strongly supported by BioGPS gene expression data to be expressed in Human COLO205 cells WB Suggested Anti-LASS6  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:12500  Positive Control: COLO205 cell lysate  CERS6 is strongly supported by BioGPS gene expression data to be expressed in Human COLO205 cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to LASS6 on formalin-fixed paraffin-embedded human colon. [antibody concentration 3 ug/ml] LASS6 monoclonal antibody (M01), clone 5H7 Western Blot analysis of LASS6 expression in HeLa . 100 μg Log in to see 11 to 12 Days
$440.00
Details
Human Mouse Un-conjugated ELISA, WB LASS6 polyclonal antibody (A01), Lot # 061229JCSa Western Blot analysis of LASS6 expression in IMR-32 Western Blot detection against Immunogen (33.81 KDa) . 50 μL Log in to see 11 to 12 Days
$305.71
Details
Human Mouse Un-conjugated ELISA, IHC, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (33.44 KDa) . Dilution: 1:500~1000 100 μg Log in to see 8 to 11 Days
$527.50
Details
Human Mouse Un-conjugated ELISA, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (33.44 KDa) . Dilution: 1:500~1000 100 μg Log in to see 8 to 11 Days
$527.50
Details
Human Rabbit Un-conjugated WB 0.1 mg Log in to see 11 to 13 Days
$668.96
Details
Cow Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB   0.1 mg Log in to see 8 to 11 Days
$474.10
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Human Adrenal (formalin-fixed, paraffin-embedded) stained with LASS6 antibody ABIN396945 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Human Small Intestine (formalin-fixed, paraffin-embedded) stained with LASS6 antibody ABIN396945 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated WB LASS6 Antibody (C-term)  western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the LASS6 antibody detected the LASS6 protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details

Top referenced anti-Ceramide Synthase 6 Antibodies

  1. Human Polyclonal CERS6 Primary Antibody for ELISA, WB - ABIN566978 : Senkal, Ponnusamy, Rossi, Bialewski, Sinha, Jiang, Jazwinski, Hannun, Ogretmen: Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas. in Molecular cancer therapeutics 2007 (PubMed)
    Show all 9 Pubmed References

  2. Human Monoclonal CERS6 Primary Antibody for IHC (p), ELISA - ABIN566979 : : in 1970 (PubMed)
    Show all 7 Pubmed References

More Antibodies against Ceramide Synthase 6 Interaction Partners

Human Ceramide Synthase 6 (CERS6) interaction partners

  1. both SphK1 overexpression and S1P addition increased mTOR phosphorylation as shown by ELISA, while S1PR2 inhibition had the inverse effect. These data suggest that CerS6 and SphK1 regulate mTOR signaling in breast cancer cell proliferation. Moreover, mTOR activity can be regulated by the balance between S1P and C16ceramide, which is generated by CerS6.

  2. ceramide synthase (CerS)6 was specifically up-regulated in zone 3 hepatocytes in alcoholic steatosis

  3. This study has shown that by direct transcriptional activation of CerS6, p53 can regulate specific ceramide biosynthesis, which contributes to the pro-apoptotic cellular response.

  4. silencing of CerS6 induced the increased expression of GLUT1, which downregulated the expression of WNT5A and enhanced the invasion and proliferation of melanoma cells.

  5. Identification of CerS6 and ceramide pathways as a novel Methotrexate target.

  6. These results suggest that the phosphorylation of ceramide synthases may be a key regulatory point in the control of the distribution and levels of sphingolipids of various acyl-chain lengths.

  7. stichoposide D inhibits growth of experimental leukemia by activating Fas/ceramide synthase 6/p38 kinase in lipid rafts

  8. CERS6-dependent ceramide synthesis and maintenance of ceramide in the cellular membrane are essential for lamellipodia formation and metastasis.

  9. Data indicate that ceramide synthase 6 (CerS6) expression is upregulated in leukocytes from multiple sclerosis (MS) patients.

  10. On the basis of its pivotal role in regulating cell death upon COX dysfunction, CerS6 might potentially represent a novel target for therapeutic intervention in mitochondrial diseases caused by COX dysfunction.

  11. Taken together, these results suggest that increased expression of CerS6 can mediate transcriptional activation of acid ceramidase in a JNK-dependent manner that is independent of CerS6 activity.

  12. CerS6 as a novel epithelial-mesenchymal transition-regulated gene that has a pivotal role in the regulation of cell migration.

  13. Upregulation of CERS6 in an experimental autoimmune encephalomyelitis model is sex dependent.

  14. Co-expression of CerS2 with CerS4/CerS6 reversed the inhibitory effect of long chain ceramides on cell proliferation and the induction of apoptosis. we detected no effect on cell proliferation.

  15. folate withdrawal also induced CerS6/C16-ceramide elevation accompanied by p53 accumulation. Overall, these novel findings link folate and de novo ceramide pathways in cellular stress response.

  16. The transiently increased expression of ceramide synthase (CerS6) correlates to the clinical finding that C(16:0)-Cer levels are increased 1.9-fold in cerebrospinal fluid of multiple sclerosis patients.

  17. Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network

  18. ionizing radiation induces de novo synthesis of ceramide to influence HeLa cell apoptosis by specifically activating CerS isoforms 2, 5, and 6 that generate opposing anti- and pro-apoptotic ceramides in mitochondrial membranes.

  19. CerS2 and CerS6 mRNA was significantly elevated in breast cancer tissue compared to paired normal tissue, with approximately half of the individuals showing elevated CerS2 and CerS6 mRNA.

  20. Findings indicate that mda-7/IL-24 induces PERK activation that triggers production of ceramide, ceramide synthase 6 and thioredoxin, which in turn promote glioma cell autophagy and cell death.

Mouse (Murine) Ceramide Synthase 6 (CERS6) interaction partners

  1. ceramide synthase (CerS)6 was specifically up-regulated in experimental alcoholic steatosis in vivo and in vitro

  2. CerS1, -2, and -6 are hyperacetylated in the mitochondria of SIRT3-null mice.

  3. These results suggest that the phosphorylation of ceramide synthases may be a key regulatory point in the control of the distribution and levels of sphingolipids of various acyl-chain lengths.

  4. CerS6 deletion increases energy expenditure and improves glucose tolerance, not only in CerS6(Delta/Delta) mice, but also in brown adipose tissue- (CerS6(DeltaBAT)) and liver-specific (CerS6(DeltaLIVER)) CerS6 knockout mice.

  5. Data show that ceramide synthase 6 knockout (CerS6KO) experimental autoimmune encephalomyelitis (EAE) mice exhibit exacerbated progression of clinical symptoms.

  6. Data indicate that oxidized phospholipids (OxPLs)-induced ceramide synthases (CerS1-Cers6) activity in macrophages is responsible for the accumulation of ceramide.

  7. CerS6 protein is N-glycosylated and expressed in several tissues of mice, mainly kidney, small and large intestine, and brain.

  8. An important role is revealed for C16:0-Cer (ceramide synthase 6) in the inflammatory process and subsequently in the induction of experimental autoimmune encephalitis.

  9. Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network

Ceramide Synthase 6 (CERS6) Antigen Profile

Protein Summary

May be involved in sphingolipid synthesis or its regulation (By similarity).

Gene names and symbols associated with CERS6

  • ceramide synthase 6 (CERS6) antibody
  • ceramide synthase 6 (cers6) antibody
  • ceramide synthase 6 (Cers6) antibody
  • 4732462C07Rik antibody
  • AW544719 antibody
  • CERS5 antibody
  • CERS6 antibody
  • Lass6 antibody
  • RGD1561599 antibody
  • si:ch211-278b7.1 antibody
  • T1L antibody

Protein level used designations for CERS6

LAG1 homolog, ceramide synthase 6 , lass6 , longevity assurance homolog 6 , LAG1 longevity assurance homolog 6

GENE ID SPECIES
100052305 Equus caballus
564867 Danio rerio
741293 Pan troglodytes
253782 Homo sapiens
241447 Mus musculus
366065 Rattus norvegicus
771503 Gallus gallus
488387 Canis lupus familiaris
100126279 Sus scrofa
616901 Bos taurus
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