Cerebellin 1 Precursor Proteins (CBLN1)

CBLN1 encodes a cerebellum-specific precursor protein, precerebellin, with similarity to the globular (non-collagen-like) domain of complement component C1qB. Additionally we are shipping CBLN1 Antibodies (40) and CBLN1 Kits (20) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CBLN1 869 P23435
CBLN1 498922 P63182
CBLN1 12404 Q9R171
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Top CBLN1 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human CBLN1 Protein. 100 μg Log in to see 11 to 18 Days
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days

CBLN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Rat (Rattus)

Mouse (Murine)

More Proteins for Cerebellin 1 Precursor (CBLN1) Interaction Partners

Human Cerebellin 1 Precursor (CBLN1) interaction partners

  1. Cbln1 and Cbln2 are co-expressed in the endolysosomal compartment of the thalamic neurons responsible for the synaptic alterations in striatum of Cbln1-null mice.

Mouse (Murine) Cerebellin 1 Precursor (CBLN1) interaction partners

  1. Results show that Cbln1, Cbln2, and Cbln4 are abundantly expressed in nearly all brain regions, but exhibit strikingly different expression patterns and developmental dynamics. Using newly generated knockin reporter mice for Cbln2 and Cbln4, we find that Cbln2 and Cbln4 are not universally expressed in all neurons, but only in specific subsets of neurons.

  2. results suggest that gene and seizure interactions in ventral tegmental area glutamatergic neurons impair sociability by downregulating Cbln1, a key node in the expanding protein interaction network of autism genes

  3. Despites its well known role in motor coordination and motor learning, whether and how the cerebellum is involved in cognitive functions remains less clear. Cerebellin 1 (Cbln1) is highly expressed in the cerebellum and serves as an essential synaptic organizer. Although genes encoding Cbln1 and its receptor are associated with many psychiatric disorders, it remains unknown whether such cognitive impairments are caused by

  4. amplitude and frequency of mIPSCs were increased in cbln1-null cerebellar slices.

  5. This study provides evidence for involvement of Cbln1 in nociception and provides a platform for continued exploration of involvement of novel neuropeptides in the regulation of nociceptive transmission

  6. that neurons expressing Cblns 1, 2, and 4 tend to occupy different laminar positions within the dorsal spinal cord

  7. extracerebellar structures or remaining PF-PC synapses in cbln1(-/-) mice may be sufficient for the expression, maintenance, and extinction of its memory trace.

  8. Cbln1 released from parallel fiber Purkinje cells induces dynamic structural changes in parallel fibers.

  9. [review] The Cbln1-GluRdelta2 receptor complex is located at the cleft of parallel fiber-Purkinje cell synapses and bidirectionally regulates both presynaptic and postsynaptic differentiation.

  10. GluRdelta1 stimulated inhibitory synapse formation in the presence of Cbln1 or Cbln2

  11. Data show that Cbln1 and Cbln2, but not Cbln4, specifically bind to neurexin 1alpha and -beta and induce synaptogenesis in cerebellar, hippocampal and cortical neurons in vitro.

  12. These results suggest that Cbln1 and Cbln2 play a role in synapse formation of cortical neurons by interacting with NRXNs containing S4.

  13. Otolin 1 interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1 in the inner ear.

  14. Our observation that loss of Cbln1 leads to increased numbers of striatal medium spiny neurons' dendritic spines suggests that modulating thalamostriatal Cbln1 may be a novel means of improving symptoms or slowing progression in Parkinson's disease.

  15. the flap loop (Arg321-Trp339) in the NTD of GluD2 (GluD2-NTD) was identified as a crucial region for the binding to Cbln1 and the induction of presynaptic differentiation.

  16. Results suggest that GluRdelta2 mediates cerebellar synapse formation by interacting with presynaptic NRXNs through Cbln1.

  17. study found that Cbln1 binds directly to the N-terminal domain of glutamate receptor delta2 (GluD2); results indicate that the Cbln1-GluD2 complex is a unique synapse organizer that acts bidirectionally on both pre- and postsynaptic components

  18. the cleavages required to produce cerebellin influence the subunit stoichiometry of Cbln1 complexes

  19. In the developing brain, Cbln1 mRNA appeared as early as embryonic day 10-13, and exhibited transient up-regulation during the late embryonic and neonatal periods.

  20. Cbln1 is required for endoplasmic reticulum export and secretion of Cbln3.

CBLN1 Protein Profile

Protein Summary

This gene encodes a cerebellum-specific precursor protein, precerebellin, with similarity to the globular (non-collagen-like) domain of complement component C1qB. Precerebellin is processed to give rise to several derivatives, including the hexadecapeptide, cerebellin, which is highly enriched in postsynaptic structures of Purkinje cells. Cerebellin has also been found in human and rat adrenals, where it has been shown to enhance the secretory activity of this gland.

Gene names and symbols associated with Cerebellin 1 Precursor Proteins (CBLN1)

  • cerebellin 3 precursor (cbln3)
  • cerebellin 1 precursor (cbln1)
  • cerebellin 1 precursor L homeolog (cbln1.L)
  • cerebellin 1 precursor (CBLN1)
  • cerebellin 1 precursor (Cbln1)
  • cerebellin 1 precursor protein (Cbln1)
  • AI323299 protein
  • CBLN1 protein
  • MGC145915 protein
  • zgc:92807 protein

Protein level used designations for Cerebellin 1 Precursor Proteins (CBLN1)

Cerebellin-1 , cerebellin 1 , sghC1q01 , cerebellin 1 precursor , cerebellin-1 , precerebellin , cerebellin 1 precursor protein , Precerebellin , precerebellin 1 , brain protein D3

100195323 Salmo salar
436793 Danio rerio
495934 Xenopus laevis
745969 Pan troglodytes
771265 Gallus gallus
779761 Xenopus (Silurana) tropicalis
869 Homo sapiens
498922 Rattus norvegicus
618604 Bos taurus
100127148 Sus scrofa
611712 Canis lupus familiaris
12404 Mus musculus
100355335 Oryctolagus cuniculus
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