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Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity). Additionally we are shipping Chaperonin GroEL Proteins (3) and many more products for this protein.
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The mechanism involved in the interaction of HSP60-Ass conjugate with HLA-DR-DRB allele considering the fact that Ass (1-42) is highly immunogenic in human and interactions evoked highly robust T-cell response through MHC class II binding predictions.
HSP60 (show HSPD1 Antibodies) showed pro-inflammatory properties in bronchial epithelial cells mediated by activation of TLR-4 (show TLR4 Antibodies)-related molecules.
HSP60 (show HSPD1 Antibodies) silencing deactivates the mTOR (show FRAP1 Antibodies) pathway to suppress glioblastoma progression
the effect of Hsp60 (show HSPD1 Antibodies) on differentiation and invasion of hepatocellular carcinoma cells might be associated with mitochondrial biogenesis
The results demonstrate that HSP60 (show HSPD1 Antibodies) participates in mitochondrial progesterone synthesis. These findings provide novel insights into progesterone synthesis in the human placenta and its role in maintaining pregnancy.
Clinical data showed that upregulation of miR (show MLXIP Antibodies)-382/3-NT and downregulation of HSPD1 (show HSPD1 Antibodies)/Trx (show VAC14 Antibodies) were also observed in IgA (show IgA Antibodies) nephropathy patients with renal interstitial fibrosis. These data supported a novel mechanism in which miR (show MLXIP Antibodies)-382 targets HSPD1 (show HSPD1 Antibodies) and contributes to the redox imbalance in the development of renal fibrosis.
Low HSP60 (show HSPD1 Antibodies) expression is associated with beta-cell hypertrophy and dysfunction.
high level of ROS (show ROS1 Antibodies) is needed for tumorigenesis and progression in tumors with low HSP60 (show HSPD1 Antibodies) expression
HSP60 (show HSPD1 Antibodies) regulation of SOX9 (show SOX9 Antibodies) ubiquitination mitigates the development of knee osteoarthritis.
These findings shed some light on how a tumor cell may avert apoptosis using Hsp60 (show HSPD1 Antibodies) and point to the anti-cancer potential of drugs, such as CubipyOXA, which interfere with Hsp60 (show HSPD1 Antibodies)/pC3 (show PCSK1 Antibodies) complex formation, and thus allow the apoptotic cascade to proceed.
This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13.
60 kDa chaperonin
, 60 kDa heat shock protein, mitochondrial
, P60 lymphocyte protein
, chaperonin 60
, heat shock protein 65
, mitochondrial matrix protein P1
, short heat shock protein 60 Hsp60s1
, chaperonin GroEL
, molecular chaperone GroEL