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CHMP1A encodes a member of the CHMP/Chmp family of proteins which are involved in multivesicular body sorting of proteins to the interiors of lysosomes. Additionally we are shipping Charged Multivesicular Body Protein 1A Proteins (7) and many more products for this protein.
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we identified Ser (show SIGLEC1 Antibodies)(179) and Ser (show SIGLEC1 Antibodies)(182) located in the C-terminal region of the CHMP1A as major phosphorylation sites that cause a mobility shift.
Study reports the discovery of a chimeric RNA between ZC3HAV1L and CHMP1A in human, located on chromosome 7 and 16, respectively. The fusion occurs at an exon-exon boundary, and was detected both computationally and experimentally from different cells or tissue types.
Our results suggest that CHMP1A serves as a critical link between cytoplasmic signals and BMI1 (show BMI1 Antibodies)-mediated chromatin modifications that regulate proliferation of central nervous system progenitor cells.
our results demonstrate that Chmp1A functions as a tumor suppressor gene in renal cells
Chmp1A regulates tumor growth through ATM (show ATM Antibodies) sugnaling and that neclear locaization of Chmp1A is reqired for the growth inhibition and ATM (show ATM Antibodies) activation.
UBPY (show USP8 Antibodies) MIT domain and another ubiquitin isopeptidase, AMSH (show STAMBP Antibodies), reveals common interactions with CHMP1A and CHMP1B (show CHMP1B Antibodies) but a distinct selectivity of AMSH (show STAMBP Antibodies) for CHMP3/VPS24 (show CHMP3 Antibodies), a core subunit of the ESCRT-III complex, and UBPY (show USP8 Antibodies) for CHMP7 (show CHMP7 Antibodies).
Chmp1A is a novel tumor suppressor, especially in pancreas and that Chmp1A regulates tumor growth potentially through p53 (show TP53 Antibodies) signaling pathway.
Both Vps4A (show VPS4A Antibodies) and CHMP1A localized in the vicinity of viral cytoplasmic assembly compartments, sites of viral maturation that develop in Cytomegalovirus-infected cells. Thus, ESCRT machinery is involved in the final steps of HCMV replication.
This gene encodes a member of the CHMP/Chmp family of proteins which are involved in multivesicular body sorting of proteins to the interiors of lysosomes. The initial prediction of the protein sequence encoded by this gene suggested that the encoded protein was a metallopeptidase. The nomenclature has been updated recently to reflect the correct biological function of this encoded protein. Several transcripts encoding different isoforms have been found for this gene.
charged multivesicular body protein 1/chromatin modifying protein 1
, charged multivesicular body protein 1a
, chromatin modifying protein 1A
, procollagen (type III) N-endopeptidase
, protease, metallo, 1, 33kD
, vacuolar protein sorting-associated protein 46-1
, chromatin-modifying protein 1a