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CCL14, chemokine (C-C motif) ligand 14, is one of several CC cytokine genes clustered on 17q11.2.
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TMEM88, CCL14, and CLEC3B (show CLEC3B Antibodies) genes were stable and available in predicting the survival and palindromia time of hepatocellular carcinoma. These genes could function as potential prognostic genes contributing to improve patients' outcomes and survival
CCL2 (show CCL2 Antibodies), 3, 14 have roles in stimulating macrophage bone marrow homing, proliferation, and polarization in multiple myeloma
CCL14 is a critical mediator of the JARID1B (show KDM5B Antibodies)/LSD1 (show KDM1A Antibodies)/NuRD complex in regulation of angiogenesis and metastasis in breast cancer.
Functional data from activity assays by intracellular calcium flux and inhibition of CCR5-mediated HIV-1 entry show that only CCL14 [9-74] is fully active at these near-physiological concentrations where CCL14 [9-74] is monomeric and CCL14 is dimeric
CCL14 is involved in mechanisms by which trophoblast cells migrate during early pregnancy.
SLE, this study reveals strong associations with a marker and a haplotype encompassing the CCL14 gene, which suggests that a lupus relevant variant may lie within or in the proximity of this haplotype.
D6 cooperates with CD26 (show DPP4 Antibodies) in the negative regulation of CCL14 by the selective degradation of its biologically active isoform.
This gene, chemokine (C-C motif) ligand 14, is one of several CC cytokine genes clustered on 17q11.2. The CC cytokines are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by this gene induces changes in intracellular calcium concentration and enzyme release in monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Read-through transcripts are also expressed that include exons from the upstream cytokine gene, chemokine (C-C motif) ligand 15, and are represented as GeneID: 348249.
chemokine (C-C motif) ligand 14
, C-C motif chemokine 14
, chemokine CC-1/CC-3
, chemokine CC-3
, hemofiltrate CC chemokine 1
, new CC chemokine 2
, small inducible cytokine subfamily A (Cys-Cys), member 14
, small-inducible cytokine A14