Chemokine (C-C Motif) Ligand 22 Proteins (CCL22)

CCL22 is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Additionally we are shipping CCL22 Antibodies (187) and CCL22 Kits (113) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CCL22 6367 O00626
CCL22 20299 O88430
CCL22 117551  
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Top CCL22 Proteins at antibodies-online.com

Showing 10 out of 67 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse Un-conjugated 25 μg Log in to see 10 to 12 Days
$251.53
Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Escherichia coli (E. coli) Human Un-conjugated 25 μg Log in to see 10 to 12 Days
$251.53
Details
Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 15 to 18 Days
$640.00
Details
Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
$704.00
Details
Escherichia coli (E. coli) Rat His tag,GST tag 100 μg Log in to see 15 to 18 Days
$707.00
Details
Escherichia coli (E. coli) Cow His tag,GST tag 100 μg Log in to see 15 to 18 Days
$768.00
Details
Escherichia coli (E. coli) Dog His tag,GST tag 100 μg Log in to see 15 to 18 Days
$800.00
Details

CCL22 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , , ,
Mouse (Murine) , ,
,
Rat (Rattus)

More Proteins for Chemokine (C-C Motif) Ligand 22 (CCL22) Interaction Partners

Human Chemokine (C-C Motif) Ligand 22 (CCL22) interaction partners

  1. Both CCL1 and CCL22 were expressed in most breast cancer tissues. CCL1 was significantly over-expressed in invasive breast cancer as compared to normal breast tissue. CCL1, but surprisingly not CCL22, showed a significant correlation with the number of tumor-infiltrating FoxP3+ Treg

  2. This review presents key clinical studies of Multiple sclerosis together with experimental studies in animals that have demonstrated functional roles of CCR4, CCL17, and CCL22 in experimental autoimmune encephalomyelitis pathogenesis. [review]

  3. MDC might serve as a marker of pharmacological therapy response in major depressive disorder

  4. Data suggest that high levels of CCL17 and CCL22 in endometrium in women with endometriosis promote (1) recruitment of Tregs, (2) immunosuppression of Tregs, and (3) angiogenesis in endometrium. (Tregs = regulatory T cells)

  5. blood CCL22 levels were positively associated with IgE sensitization at age 2. A high cord blood CCL22/CXCL10 chemokine ratio was significantly associated with a higher risk of allergic sensitization at age 3.

  6. Tumor-associated macrophages promote prostate cancer migration through activation of the CCL22-CCR4 signaling axis.

  7. Elevations in serum MDC and BLC were independently associated with the significant risk of early stage lung adenocarcinoma, even in non-smokers and in stage IA patients.

  8. These results showed that the higher levels of CXCL10, CCL20 and CCL22 were associated with ischemic heart disease. The serum levels of chemokines may influence by the certain traditional risk factors of IHD and some studied SNPs, but did not influence by treatment and gender of patients.

  9. CCL22 plays an important role in supporting gastric cancer development presumably by increasing the percentage of regulatory T cells in the tumor microenvironments. CCL22 levels in sera have a predictive value for gastric cancer peritoneal metastasis and the early recurrence.

  10. The CCL22-mediated enhancement of antitumor responses is however not due to conversion, but rather to redirection of existing regulatory T cells to the site of cutaneous overexpression.

  11. CCL22 and IL-37 with a co-localization in non-small cell lung cancer A549 cells inhibited the proliferation and epithelial-mesenchymal transition process

  12. Data suggest that Th1 (IFN-gamma-inducible protein-10 IP-10/CXCL10) and Th2 (thymus and activation regulated chemokine TARC/CCL17) and (macrophage derived chemokine MDC/CCL22) cooperatively play a role in the development of ankylosing spondylitis (AS).

  13. increased amounts released by neutrophils from fibromyalgia patients

  14. Our results demonstrate that CCL22 is expressed in human placenta. Decidual expression was only observed in miscarriage conditions and correlates with Treg infiltration.

  15. Distinctive Treg associated CCR4-CCL22 expression profile with altered frequency of Th17/Treg cell in the immunopathogenesis of Pemphigus Vulgaris.

  16. type I IFN blocks the regulatory T cell-attracting chemokine CCL22 and thus helps limit the recruitment of regulatory T cells to tumors

  17. First-episode psychosis patients had higher serum CCL22, which decreased substantially following antipsychotic treatment.

  18. Elevated levels of CCL22 found in the ascites could create a chemokine gradient aiding in Treg cells migration. Increased Tregs percentage in the local microenvironment of ovarian cancer might be an important mechanism of immunosuppression.

  19. Circulating CCL22 levels are related to both glioma risk and survival duration independent of age, histology, grade and IDH mutation status. CCL22 should be considered a marker of immune status with potential prognostic value

  20. CCL22 is a novel mediator of lung inflammation following hemorrhage and resuscitation

Mouse (Murine) Chemokine (C-C Motif) Ligand 22 (CCL22) interaction partners

  1. the subset of peritoneal CD11b(+)CD169(+) macrophages increased and CCL22 expression level decreased significantly during the DSS-induced colitis

  2. Intratumoral administration of anti-CCL22 antibody inhibited B16F10 melanoma growth.

  3. this study shows that intravenous injection of apoptotic cells induces a subsequent increase in CCL22 expression and CCR4+ Treg cells, which contribute to the maintenance of immune homeostasis at least partially by splenic CD8alpha+ CD103+ dendritic cells

  4. CCL22-specific antibodies reveal that engagement of two distinct binding domains on CCL22 is required for CCR4-mediated function.

  5. CCL22 was localised mainly on the cell surface and or in the cytoplasm. Within sections of omental milky spot micrometastases, CCR4 was recognised on or in gastric cancer cells, constituent cells milky spots, blood cells and blood endothelial cells

  6. results show that the IL-4/CCL22/CCR4 axis is involved in the migration of Tregs to osteolytic lesion sites, and attenuates development of lesions by inhibiting inflammatory migration and the production of proinflammatory and osteoclastogenic mediators

  7. CCL22 has a role in Treg skin homing to suppress depigmentation

  8. CCL22 is a novel mediator of lung inflammation following hemorrhage and resuscitation

  9. The immunomodulatory properties of CCL22 could be harnessed for prevention of graft rejection and type 1 diabetes as well as other autoimmune disorders.

  10. Data indicate macrophage-derived chemokine CCL22 as an adjuvant could enhance the immune protective effect of NTHi-P6 protein vaccine to an extent.

  11. islet expression of CCL22 recruits Tregs and attenuates autoimmune destruction of beta cell

  12. Data show that the presence of the Ccr4 and Ccl22 transcripts were detected in brain slices.

  13. These results suggest that CCL22 functions to regulate development of experimental autoimmune encephalomyelitis through macrophage chemoattraction and effector function.

  14. role of CCL22 for the recruitment of eosinophils during allergic pleurisy

  15. functionally increased expression during Salmonella enterica serovar Typhimurium infection of dendritic cells

  16. Regulatory elements of the CCL22 gene required to mediate a strong and highly specific expression are included in a 4.1-kb promoter region, with the major elements active in dendritic cells and B cells being located in a small proximal 250-bp region.

  17. CCL22 was selectively upregulated in osteoclast-like cells derived from RAW264.7 cells and mouse bone marrow cells upon stimulation with RANKL (receptor activator of nuclear factor-kappaB ligand).

  18. study provides direct evidence for the presence of CCR4 and its ligands, CCL17 and CCL22, in mouse contact hypersensitivity

  19. IgE appears to be capable of stimulating basophils to produce MDC in the absence of a specific Ag, which may contribute to IgE-mediated and/or Th2-predominant allergic inflammation.

  20. When isolated, only natural killer (NK)-containing cellular fractions secrete CCL22, and the same fraction isolated from metastatic Lewis lung carcinoma (LLC)-bearing lungs secrete higher levels.

CCL22 Protein Profile

Protein Summary

This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology.

Gene names and symbols associated with CCL22

  • C-C motif chemokine ligand 22 (CCL22)
  • chemokine (C-C motif) ligand 22 (Ccl22)
  • C-C motif chemokine ligand 22 (Ccl22)
  • ABCD-1 protein
  • CCL22 protein
  • DC/B-CK protein
  • DCBCK protein
  • Mdc protein
  • Scya22 protein
  • STCP-1 protein

Protein level used designations for CCL22

C-C motif chemokine 22 , CC chemokine STCP-1 , MDC(1-69) , macrophage-derived chemokine , small inducible cytokine A22 , small inducible cytokine subfamily A (Cys-Cys), member 22 , small-inducible cytokine A22 , stimulated T cell chemotactic protein 1 , stimulated T-cell chemotactic protein 1 , CC chemokine ABCD-1 , SMALL INDUCIBLE CYTOKINE A22 PRECURSOR (CC CHEMOKINE ABCD-1) (ACTIVATED B AND DENDRITIC CELL-DERIVED) , activated B and dendritic cell-derived , dendritic cell and B cell derived chemokine , small inducible cytokine subfamily A, member 22 , small inducible cytokine subfamily A22 , small inducible cytokine subfamily A (Cys-Cys) member 22 , chemokine (C-C motif) ligand 22

GENE ID SPECIES
6367 Homo sapiens
20299 Mus musculus
117551 Rattus norvegicus
616996 Bos taurus
736543 Pan troglodytes
100686212 Canis lupus familiaris
100516016 Sus scrofa
100716085 Cavia porcellus
101123141 Ovis aries
103348469 Oryctolagus cuniculus
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