CCL22 Protein (His tag)

Catalog No. ABIN7195054

Product Details

Target: CCL22 (Chemokine (C-C Motif) Ligand 22 (CCL22))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This CCL22 protein is labelled with His tag.

Purpose: Recombinant Human CCL22/MDC Protein (His Tag)

Sequence: Gly 25-Gln 93

Characteristics: A DNA sequence encoding the secreeted form of human CCL22 (O00626) (Gly 25-Gln 93) was expressed, with a polyhistidine tag at the N-terminus.

Purity: > 90 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 30 % Acetonitrile, 0.1 % TFA

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CCL22 (Chemokine (C-C Motif) Ligand 22 (CCL22))

Alternative Name: CCL22/MDC (CCL22 Products)

Synonyms: ABCD-1 Protein, DC/B-CK Protein, MDC Protein, SCYA22 Protein, STCP-1 Protein, DCBCK Protein, Scya22 Protein, Mdc Protein, CCL22 Protein, C-C motif chemokine ligand 22 Protein, chemokine (C-C motif) ligand 22 Protein, CCL22 Protein, Ccl22 Protein

Background:

Background: Chemokine (C-C motif) ligand 22(ABCD-1 / CCL22)is a kind of CC chemokine which is a family of secreted proteins involved in immunoregulatory and inflammatory processes. The cytokine displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. This ABCD-1 / CCL22 chemokine binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated / effector T lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. ABCD-1 / CCL22 is highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus, and in Langerhans' cell histiocytosis and atopic dermatitis but not in dermatopathic lymphadenopathy. This chemokine is also found in lymph node, appendix, activated monocytes, resting and activated macrophages. This protein is lower expressed in lung and spleen and very weekly expressed in small intestine.

Synonym: A-152E5.1,ABCD-1,DC/B-CK,MDC,SCYA22,STCP-1

Molecular Weight: 9.7 kDa

UniProt: O00626