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Plasma concentrations of CCL15, the human homolog of mouse CCL9, were elevated in a previously published cohort of 211 cGVHD patients compared with controls and associated with NRM. In a cohort of 792 patients, CCL15 measured at day +100 could not predict cGVHD occurring within the next 3 months with clinically relevant sensitivity/specificity.
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CCL9 secreted by splenic macrophages induces a CCR1dependent accumulation of MDSCs.
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Results show that MIP-1g promotes tumor cell growth in vitro through the activation of NFkB pathway in colorectal tumor cells.
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we report that chemokine CCL9 was highly induced in Gr-1(+)CD11b(+) immature myeloid cells and in premetastatic lung in tumor-bearing mice
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Plasmid codelivery of murine CCL19 and CCL28 enhanced Ag-specific systemic and mucosal Ab responses to HIV-1 gp140, augmented balanced Th1/Th2 responses, and increased lymphocyte subsets in various lymphoid tissues.
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Taken together the data presented strongly suggest that 4T1 mammary tumor cell invasion in vitro is promoted by D1 mesenchymal stem cell secretions, especially the chemokines CCL5 and CCL9.
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There is protein-DNA interaction between ETV5 and Ccl9, suggesting that ETV5 might be a direct regulator of Ccl9 expression.
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Mice lacking RXRalpha in myeloid cells exhibit reduced levels of CCL6 and CCL9, impaired recruitment of leukocytes to sites of inflammation, and lower susceptibility to sepsis.
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Results reveal the potential involvement of CCL9 and CCR1 in macrophage and microglial cells by CpG-ODNs and may help understanding the role of the chemokine/chemokine receptor pairs in macrophage/microglia under physiologic and pathologic conditions.
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MRP-2 may be an important contributing factor in the development of atherosclerosis
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CCL9 and its receptor CCR1 are the major chemokine and receptor species expressed by osteoclasts, CCL9 has a role in the regulation of bone resorption
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An important role for CCL9 is demonstrated in the recruitment of CD11b+ dendritic cells to the dome regions of mouse Peyer's patches.
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MIP-1 gamma plays an important role in the differentiation & survival of osteoclasts, & bone resorption, most likely via an autocrine pathway.
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Keratinocyte-derived chemokine (KC) and MIP-2 alpha differ in their mediation of neutrophil function (apoptosis and chemotaxis) and contribution to the pathogenesis of lung injury following hemorrhage subsequent to sepsis.
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BCR/ABL repressed CCL9 expression at the transcriptional level
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the chemokines CCL6 and CCL9 as genes prominently induced by the type I IFNs and ICSBP
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involved in calcium mobilization and chemotaxis
