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Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Additionally we are shipping CCR10 Antibodies (139) and CCR10 Kits (6) and many more products for this protein.
Showing 4 out of 4 products:
study found that the inflammatory chemokine (show CCL1 Proteins) CCL5 (show CCL5 Proteins) is mostly retained (75%) during the resolution of zymosan A peritonitis in mice; CCL5 (show CCL5 Proteins) exerts a novel proresolving role on macrophages when acting in concert with apoptotic PMN (show TBCE Proteins)-expressed D6.
this study shows that losartan and dexamethasone may suppress inflammatory responses in IgA nephropathy by inhibiting CCR10 expression in Th22 cells
Further examination revealed that proximity of pro-lymphangiogenic macrophages to developing lymphatic vessel surfaces is increased in ACKR2-deficient mice and reduced in CCR2-deficient mice.
some cells, including plasmacytoid dendritic cells, can express both CCR2 (show CCR2 Proteins) and ACKR2; that Ly6C(high) monocytes have particularly strong CCL2 (show CCL2 Proteins)-scavenging potential in vitro and in vivo; and that CCR2 (show CCR2 Proteins) is a much more effective CCL2 (show CCL2 Proteins) scavenger than ACKR2.
Our in vivo analysis demonstrated that uniform expression of Ccr10 on MSCs and alteration of Ccl27 (show CCL27 Proteins) level in the skin enhance extravasation of stem cells from circulation and facilitate their migration within cutaneous tissue
Chemokine (show CCL1 Proteins) decoy receptor D6 limits CC-chemokine (show CCL1 Proteins)-dependent pathogenic inflammation and is required for adequate cardiac remodeling after myocardial infarction.
control of CCR2 ligands by D6 regulates the traffic of Ly6C(high) monocytes and controls their immunosuppressive potential.
D6, by suppressing inflammatory chemokine (show CCL1 Proteins) binding to lymphatic surfaces, and thereby preventing inflammatory leukocyte adherence, is a regulator of lymphatic function and a contributor to the integration of innate and adaptive immune responses.
identify novel D6(active) B1-cell subsets, including those we term B1d, which lack CD5 (show CD5 Proteins) and CD11b (show ITGAM Proteins) but exhibit typical B1-cell properties, including spontaneous ex vivo production of IgM (show CD40LG Proteins), IL-10 (show IL10 Proteins), and anti-phosphorylcholine antibody
CCL27 (show CCL27 Proteins) drives baseline recruitment of Herpes simplex virus-specific CD8 (show CD8A Proteins) T cells expressing CCR10, while interferon (show IFNA Proteins)-responsive CXCR3 (show CXCR3 Proteins) ligands recruit additional cells in response to virus-driven inflammation.
Findings support the notion that CCR10 and its ligand CCL27 (show CCL27 Proteins) may contribute to the skin infiltration of malignant T-cells in mycosis fungoides and adult T-cell leukemia/lymphoma.
low CCL27 (show CCL27 Proteins)/CCR10 and CXCL12 (show CXCL12 Proteins)/CXCR4 (show CXCR4 Proteins) intratumoral mRNA ratios are associated with melanoma progression
CCR7 (show CCR7 Proteins) overexpression correlated with expression of metallothionein (show MT Proteins), while CCR10 was associated with cerebral metastases. CCR7 (show CCR7 Proteins) and CCR10 overexpressions were associated with a worse outcome independent of Breslow's tumor thickness and Clark level.
unlike blood plasmacytoid dendritic cells (pDCs), a subset of tonsil pDCs express functional CCR6 (show CCR6 Proteins) and CCR10, and their respective ligands CCL20 (show CCL20 Proteins) and CCL27 (show CCL27 Proteins) are detected in inflamed epithelia
The high fraction of circulating IgA+ and IgG+ B cells expressing CCR9 (show CCR9 Proteins) and CCR10 in the first months of life indicates activation of naive B cells in the gut (show GUSB Proteins), coinciding with bacterial colonization.
TLR2 ligands induce CCR9 and CCR10 expression by circulating B-cells and increase their chemotaxis. TLR2 stimulation also induced J chain and IgA production demonstrating the induction of mucosal-like antibody secreting cells.
CCR10 and its ligand CCL27 (show CCL27 Proteins) may contribute to the skin infiltration of malignant T-cells in cutaneous T-cell lymphoma.
gene expression of CCR10 was increased by recombinant ANXA1 (show ANXA1 Proteins) and the N-terminal ANXA1 (show ANXA1 Proteins) peptide
CCR10-CTACK/CCL27 (show CCL27 Proteins) interactions between circulating T cells and keratinocytes would seem to play an important role in the pathophysiology of mycosis fungoides.
Study showed bovine CCL28 mediating cellular chemotaxis via CCR10 chemokine receptor.
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues\; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27\; MIM 604833)\; CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002
CC chemokine receptor 10
, chemokine C-C motif receptor 10
, C-C chemokine receptor D6
, D6 beta-chemokine receptor
, chemokine binding protein 2
, chemokine-binding protein 2
, chemokine-binding protein D6
, C-C CKR-10
, C-C chemokine receptor type 10
, G protein-coupled receptor 2
, G-protein coupled receptor 2
, chemokine C-C receptor 9