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Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors.
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CCR10 may be a key regulator in breast cancer cell invasion and migration
CCR10/CCL27 (show CCL27 Proteins) crosstalk mediated drug resistance, contributing to failure of proteasome-inhibitors in multiple myeloma.
CCL27 (show CCL27 Proteins) drives baseline recruitment of Herpes simplex virus-specific CD8 (show CD8A Proteins) T cells expressing CCR10, while interferon (show IFNA Proteins)-responsive CXCR3 (show CXCR3 Proteins) ligands recruit additional cells in response to virus-driven inflammation.
Findings support the notion that CCR10 and its ligand CCL27 (show CCL27 Proteins) may contribute to the skin infiltration of malignant T-cells in mycosis fungoides and adult T-cell leukemia/lymphoma.
low CCL27 (show CCL27 Proteins)/CCR10 and CXCL12 (show CXCL12 Proteins)/CXCR4 (show CXCR4 Proteins) intratumoral mRNA ratios are associated with melanoma progression
CCR7 (show CCR7 Proteins) overexpression correlated with expression of metallothionein (show MT Proteins), while CCR10 was associated with cerebral metastases. CCR7 (show CCR7 Proteins) and CCR10 overexpressions were associated with a worse outcome independent of Breslow's tumor thickness and Clark level.
unlike blood plasmacytoid dendritic cells (pDCs), a subset of tonsil pDCs express functional CCR6 (show CCR6 Proteins) and CCR10, and their respective ligands CCL20 (show CCL20 Proteins) and CCL27 (show CCL27 Proteins) are detected in inflamed epithelia
The high fraction of circulating IgA+ and IgG+ B cells expressing CCR9 (show CCR9 Proteins) and CCR10 in the first months of life indicates activation of naive B cells in the gut (show GUSB Proteins), coinciding with bacterial colonization.
TLR2 ligands induce CCR9 and CCR10 expression by circulating B-cells and increase their chemotaxis. TLR2 stimulation also induced J chain and IgA production demonstrating the induction of mucosal-like antibody secreting cells.
CCR10 and its ligand CCL27 (show CCL27 Proteins) may contribute to the skin infiltration of malignant T-cells in cutaneous T-cell lymphoma.
this study shows that losartan and dexamethasone may suppress inflammatory responses in IgA nephropathy by inhibiting CCR10 expression in Th22 cells
Our in vivo analysis demonstrated that uniform expression of Ccr10 on MSCs and alteration of Ccl27 (show CCL27 Proteins) level in the skin enhance extravasation of stem cells from circulation and facilitate their migration within cutaneous tissue
These findings provide definite evidence that CCR10 is important in skin intraepithelial Vgamma3(+) T lymphocyte development
Blocking CCR4 (show CCR4 Proteins) and CCR10 simultaneously, or their ligands, should be beneficial in the treatment of T-cell-mediated skin diseases.
CCR10 is critical for efficient localization and accumulation of immunoglobulin A antibody-secreting cells to the lactating mammary gland.
Study showed bovine CCL28 mediating cellular chemotaxis via CCR10 chemokine receptor.
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues\; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27\; MIM 604833)\; CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002
, C-C chemokine receptor type 10
, CC chemokine receptor 10
, G protein-coupled receptor 2
, G-protein coupled receptor 2
, chemokine C-C receptor 9
, chemokine C-C motif receptor 10
, LOW QUALITY PROTEIN: C-C chemokine receptor type 10