Chemokine (C-C Motif) Receptor-Like 1 Proteins (CCRL1)

The protein encoded by CCRL1 is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. Additionally we are shipping CCRL1 Antibodies (64) and CCRL1 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CCRL1 51554 Q9NPB9
CCRL1 252837 Q924I3
Rat CCRL1 CCRL1 685243  
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Top CCRL1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,649.05
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$6,616.87
Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
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Wheat germ Human Un-conjugated   2 μg Log in to see 11 to 12 Days
$491.43
Details

CCRL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Chemokine (C-C Motif) Receptor-Like 1 (CCRL1) Interaction Partners

Human Chemokine (C-C Motif) Receptor-Like 1 (CCRL1) interaction partners

  1. Results of this study show that HEK (show EPHA3 Proteins) 293 cells express an endogenous CCRL1 (show CX3CR1 Proteins) gene only at mRNA level. These data therefore represent the important implications for the use of HEK (show EPHA3 Proteins) 293 cells as a host cell system for the study of CCX-CKR.

  2. we found that CCX-CKR expression in vitro could modulate cellular migration and invasion abilities, potentially via the regulation of other chemotactic factors/receptors.

  3. Effect of genetic variants in two chemokine (show CCL1 Proteins) decoy receptor genes, DARC (show DARC Proteins) and CCBP2, on metastatic potential of breast cancer.

  4. co-expression of DARC (show DARC Proteins), D6, and CCX-CKR significantly associated with higher survival in gastric cancer

  5. Data suggest that co-expression of CCX-CKR and CXCR3 (show CXCR3 Proteins) (chemokine receptor type 3) in T-lymphocytes results in protein multimerization and prevents CXCR3 (show CXCR3 Proteins)-mediated chemotaxis; this represents a novel mechanism of regulation of immune cell migration.

  6. Results suggest that chemokine (show CCL1 Proteins) binding to CCX-CKR recruits Gi proteins and beta-arrestin (beta-arr (show SAG Proteins)) with high affinity.

  7. Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK (show CCL25 Proteins)/mCCL25, SLC (show CCL21 Proteins)/mCCL21 and MIP (show TNPO1 Proteins)-3beta/mCCL19: comparison to human CCX-CKR.

  8. Scavenges extracellular chemokines in vivo to modify responses through CCR7 (show CCR7 Proteins).

  9. Down regulation of CCX-CKR is associated with breast cancer.

Mouse (Murine) Chemokine (C-C Motif) Receptor-Like 1 (CCRL1) interaction partners

  1. a comprehensive model of CCL19 (show CCL19 Proteins) and CCL21 (show CCL21 Proteins) transport and gradient formation in the lymph nodes (LNs) was built; predicts that ACKR4 in LNs prevents CCL19 (show CCL19 Proteins)/CCL21 (show CCL21 Proteins) accumulation in efferent lymph, but does not control intranodal gradients; instead, it attributes the disrupted interfollicular CCL21 (show CCL21 Proteins) gradients observed in Ackr4-deficient LNs to ACKR4 loss upstream

  2. ACKR4 on stromal cells aids the egress of antigen presenting cells from mouse skin, and, during inflammation, facilitates CCR7 (show CCR7 Proteins)-dependent cell trafficking by scavenging CCL19 (show CCL19 Proteins).

  3. The data shows a novel function for the chemokine receptor CCX-CKR as a regulator of TGF-beta1 (show TGFB1 Proteins) expression and epithelial-mesenchymal transition in breast cancer cells.

  4. CCRL1 is expressed in key thymic microenvironments but is dispensable for T lymphopoiesis at steady state in adult mice.

  5. stepwise acquisition of chemokine (C-C motif) receptor-like 1 (CCRL1) is a late determinant of cortical thymic epithelial cell differentiation

  6. found that lymph node fringes indeed contained physiological gradients of the chemokine (show CCL1 Proteins) CCL21 (show CCL21 Proteins), which depended on the expression of CCRL1, the atypical receptor for the CCR7 (show CCR7 Proteins) ligands CCL19 (show CCL19 Proteins) and CCL21 (show CCL21 Proteins)

  7. CCX-CKR deletion increases incidence of a spontaneous Sjogren's syndrome-like pathology, suggestive of a defect in self-tolerance. CCX-CKR(-/-) mice have fewer thymic epithelial cells per thymocyte, with defects in thymocyte distribution & frequency.

  8. CCX-CKR(-/-) have a 5-fold increase in the level of CCL21 (show CCL21 Proteins) protein in blood, and 2- to 3-fold increases in CCL19 (show CCL19 Proteins) and CCL21 (show CCL21 Proteins) in peripheral lymph nodes.

  9. Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK (show CCL25 Proteins)/mCCL25, SLC (show CCL21A Proteins)/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR. (CCX-CKR)

  10. These observations indicate that the silent chemokine receptor CCX-CKR1, regulates homeostatic leukocyte migration by controlling the availability of chemokines in the extracellular space.

CCRL1 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. Alternatively spliced transcript variants encoding the same protein have been described.

Gene names and symbols associated with CCRL1

  • atypical chemokine receptor 4 (ACKR4)
  • atypical chemokine receptor 4 (Ackr4)
  • chemokine (C-C motif) receptor-like 1 (CCRL1)
  • Chemokine receptor-like 1 (cml1)
  • chemerin chemokine-like receptor 1 (CMKLR1)
  • A630091E18Rik protein
  • CC-CKR-11 protein
  • CCBP2 protein
  • CCR-11 protein
  • CCR10 protein
  • CCR11 protein
  • Ccrl1 protein
  • CCX-CKR protein
  • CCX-CKR1 protein
  • CCX CKR protein
  • CKR-11 protein
  • Cmkbrl1 protein
  • PPR1 protein
  • VSHK1 protein

Protein level used designations for CCRL1

C-C CKR-11 , C-C chemokine receptor type 11 , CC chemokine receptor-like 1 , chemocentryx chemokine receptor , chemokine (C-C motif) receptor-like 1 , chemokine, cc motif, receptor-like protein 1 , orphan seven-transmembrane receptor, chemokine related , CC-CKR-11 , CCR-11 , CCX CKR , chemokine (C-C) receptor-like 1 , chemokine receptor CCR11 , orphan seven-transmembrane receptor , putative gustatory receptor type B , Chemokine receptor-like 1 , chemokine-like receptor 1

GENE ID SPECIES
51554 Homo sapiens
252837 Mus musculus
100037292 Sus scrofa
281672 Bos taurus
608898 Canis lupus familiaris
685243 Rattus norvegicus
100305301 Oncorhynchus mykiss
100355497 Oryctolagus cuniculus
100592093 Nomascus leucogenys
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