anti-Chemokine (C-X-C Motif) Ligand 10 (CXCL10) Antibodies

Pig (Porcine) Chemokine (C-X-C Motif) Ligand 10 (CXCL10) interaction partners

1. a SNP in CXCL10 was significantly associated with percentage of lymphocyte in blood of 20-day-old pigs and with hematocrit and mean red cell volume in blood of 80-day-old pigs

2. CXCL10 protein was detected in serum from pigs infected with a high virulence African swine fever virus isolate. Levels of CCL2 mRNA were increased in pigs infected with the high virulence isolate compared to a low virulence isolate.

3. Authors identified chemokine (C-X-C motif) ligand 10 (CXCL10), also named interferon-gamma inducible protein-10 (IP-10), as a novel target gene of miR-21.

4. These in vitro and in vivo observations suggest that interferon-gamma inducible protein 10 (IP-10) may be a reliable biomarker for immune activity induced by CpG oligodeoxynucleotides in pigs.

5. The swine CXCL10 gene contains four exons and three introns.

Human Chemokine (C-X-C Motif) Ligand 10 (CXCL10) interaction partners

1. Studied role of chemokines (including C-X-C motif chemokine ligand 11 [CXCL11] and C-X-C motif chemokine ligand 10 [CXCL10] in the CXCR3 axis with regards to angiogenesis in adipose tissue of morbidly obese patients.

2. CXCL10 blood level is associated with tuberculosis in the HIV infected patients.

3. ur results showed that a fragment consisting of residues 196-413 in MERS-N is sufficient to up-regulate CXCL10, while the N-terminal domain and serine-arginine (SR)-rich motif of MERS-N do not play a role in this up-regulation.

4. A strong correlation between elevated serum levels of IP-10 and DPPIV activity was seen in different cholestatic patient groups.

5. The level of the serum IP-10 is higher in Chronic Hepatitis C patients compared to control group, and its level significantly decreased with effective antiviral treatment.

6. hepatocellular carcinoma patients with a high concentration of CXCL10 in the tumor microenvironment had significantly poorer overall survival and disease-free survival than those with lower CXCL10 expression levels

7. Inflammatory cytokines interleukin (IL)-1alpha, IL-1beta and interferon-gamma-induced protein (IP)-10 are biomarkers for detecting asymptomatic STIs and vaginal dysbiosis (bacterial vaginosis (BV) or intermediate microbiota).

8. IP-10 is an alternative biomarker to IFN-gamma in the QFT-Plus format for the diagnosis of latent tuberculosis infection.

9. Combination of IP-10 and RANTES could be potentially used as diagnostic and monitoring biomarker in pulmonary tuberculosis management.

10. upregulated in synovium and chondrocytes following trauma

11. The SNPs of CXCL9 (rs10336) and CXCL10 (rs3921) are not associated with the incidence of acute cellular rejection

12. IP-10 is an accurate biomarker to screen febrile HIV-seronegative individuals.

13. Elevated plasma level of CXCL10 is predictive of the active phase of tuberculosis infection.

14. Results found that hepatitis A virus infection strongly induces the production of helper 1 T cell-associated chemokines, particularly CXCL10 via RIG-I-like receptor signaling, even without secreted interferons.

15. Findings show that a combination of CRP, PCT, TRAIL and IP-10 can identify bacterial infections with higher accuracy than single biomarkers and combinations of a single bacterial biomarkers combined with TRAIL and IP-10.

16. High IP10 expression is associated with multiple myeloma.

17. Circulating CXCL10 possibly reflects systemic inflammation and it is correlated with acute decompensation, acute-on-chronic liver failure and complications in patients with severe portal hypertension receiving transjugular intrahepatic portosystemic shunt

18. these findings demonstrated a more powerful prediction of early acute renal allograft rejection during the first month after transplantation by combination of multiple-biomarkers of fractalkine, IFN-gamma and IP-10, and the results might help stratify the immunologic risk of acute allograft rejection in recipients

19. results of study suggest that the CXCL10 overexpression in the salivary glands is caused mainly by IFN-gamma-stimulated salivary gland ductal cells.

20. Urinary CXCL10 reflects subclinical inflammation within the tubulointerstitial and peritubular capillary spaces, but not the vascular/systemic compartments

Mouse (Murine) Chemokine (C-X-C Motif) Ligand 10 (CXCL10) interaction partners

1. Study show that CXCL9 and CXCL10 are overexpressed in skin of HPV16 E7 transgenic mice when compared with non-transgenic animals. Immune cell infiltration to E7 transgenic skin is a consequence of epidermal hyperplasia, and that hyperplasia induces CXCL9 and CXCL10 production to recruit a subset of CXCR3+ T cells, promoting rejection of grafted E7 transgenic skin depleted of immunosuppressive lymphocytes.

2. Forced expression of CXCL10 prevents in vitro growth and metastasis of colon carcinoma cells by recruiting natural killer cells.

3. upregulated in synovium and chondrocytes following intra-articular fracture

4. FNDC4 could suppress osteoclast formation via NF-kappaB pathway and downregulation of CXCL10

5. This study explored the effect of CXCL10 on COPD induced by cigarette smoke (CS) and its underlying mechanism.

6. CXCL10, not CXCL9 or CXCL11, induced IL-9 expression in the liver tissue.

7. in vivo experiments show that the CXCL10/CXC chemokine receptor family 3 axis prevents the recruitment of macrophages, reduces inflammation, and halts the progression of the disease; the increased production of IL-1beta highlights the autoinflammatory nature of congenital hepatic fibrosis and may open novel therapeutic avenues

8. CXCL10 and blood-brain barrier permeability enhancement in rabies virus infection

9. Study shows that circulating interferon- that binds to receptors on brain endothelial cells and induces Cxcl10, is a central link in the signaling chain eliciting inflammation-induced aversion.

10. The knockout of either CXCL10 or TNF-alpha reduced germ cell apoptosis in the co-cultures of germ cells and Sertoli cells in response to MuV infection. Local injection of MuV into the testes of mice confirmed the involvement of CXCL10 in germ cell apoptosis in vivo.

11. CXCL10 has strong inhibitory effects on neovascularization, whereas MMP13 is required for neovascularization in C. albicans-infected corneas.

12. Study provided the evidence that CXCL10/CXCR3 signaling in periaqueductal gray is involved in the development of morphine analgesic tolerance via neuron-microglia interaction.

13. Results suggest that CXCL10(-/-) mice are protected against diet-induced nonalcoholic steatohepatitis (NASH), in an obesity-independent manner.

14. In conclusion, upregulated CXCL10 in steatohepatitis impairs autophagic flux by reducing autolysosome formation, thereby inhibiting autophagic protein degradation and the accumulation of ubiquitinated proteins, leading to the development of steatohepatitis.

15. These findings highlight the importance of CXCL10 signaling in the pathogenesis of rheumatoid arthritis and provide previously unidentified details of the mechanisms by which CXCL10 promotes the development of arthritis.

16. Study revealed that CXCL10 evoked an ionic current mainly carried by Cl(-) channels, suggests that Cl(-) channels are likely key molecular candidates responsible for the CXCL10-evoked neuronal activation and itch-like behaviors in a murine model of allergic contact dermatitis induced by the antigen squaric acid dibutylester. Cl(-) channels may emerge as a promising drug target for the treatment of allergic itch.

17. Collectively, these results suggest that the CXCL10/CXCR3-mediated NF-kappaB signaling pathway plays a role in the control of autonomous regulation of CXCL10 and malignant tumor properties in breast cancer 4T1 cells.

18. results show an important role for CXCR3 and CXCL10 in the tissue distribution of preimmune memory phenotype CD8 T- cells

19. In lipotoxic hepatocytes, MLK3 activates a MAPK signaling cascade, resulting in the activating phosphorylation of STAT1, and CXCL10 transcriptional upregulation.

20. These findings elucidate an NFAT-MAPK signaling paradigm for induction of isletokine expression in beta-cells and reveal IP-10 as a primary therapeutic target to prevent beta-cell-induced inflammatory loss of graft function after islet cell transplantation.

Cow (Bovine) Chemokine (C-X-C Motif) Ligand 10 (CXCL10) interaction partners

1. These results demonstrated that bovine colonic cells seem capable to respond to E. bovis merozoite I infection by the upregulation of CXCL10 and GM-CSF gene transcription.

2. IL-17A was shown to be upregulated, supporting its investigation as a potential biomarker of bTB.