anti-Chemokine (C-X-C Motif) Ligand 10 (CXCL10) Antibodies

Pig (Porcine) Chemokine (C-X-C Motif) Ligand 10 (CXCL10) interaction partners

1. a SNP in CXCL10 was significantly associated with percentage of lymphocyte in blood of 20-day-old pigs and with hematocrit and mean red cell volume in blood of 80-day-old pigs

2. CXCL10 protein was detected in serum from pigs infected with a high virulence African swine fever virus isolate. Levels of CCL2 mRNA were increased in pigs infected with the high virulence isolate compared to a low virulence isolate.

3. Authors identified chemokine (C-X-C motif) ligand 10 (CXCL10), also named interferon-gamma inducible protein-10 (IP-10), as a novel target gene of miR-21.

4. These in vitro and in vivo observations suggest that interferon-gamma inducible protein 10 (IP-10) may be a reliable biomarker for immune activity induced by CpG oligodeoxynucleotides in pigs.

5. The swine CXCL10 gene contains four exons and three introns.

Human Chemokine (C-X-C Motif) Ligand 10 (CXCL10) interaction partners

1. IP-10 is a promising marker for differentiating pulmonary tuberculosis from non- tuberculosis.[meta-analysis]

2. High CXCL10 expression is associated with Acute Respiratory Distress Syndrome.

3. the expression of CXCR3 and CXCL10 was significantly increased oral lichen planus (OLP) patients. T lymphocyte migration rate of CXCL10 stimulation group was significantly higher. CXCL10/CXCR3 axis may be related to the immune mechanism of OLP.

4. IP10 secretion induced by patient sera in peripheral nerve microvascular endothelial cells was markedly upregulated in both the multifocal acquired demyelinating sensory and motor neuropathy and multifocal motor neuropathy groups. The overproduction of IP-10 leads to the focal breakdown of the blood nerve barrier, and may help to mediate the transfer of pathogenic T cells across the BNB.

5. The up-regulated release of CXCL10 is important in the immunopathogenesis of Clostridium difficile infection (CDI), and may be served as a potential alternative biomarker for the monitoring of CDI disease severity and therapeutic efficacy.

6. Study in three Japanese patients with advanced cutaneous angiosarcoma revealed that serum levels of soluble CD163 and CXCL10 increased in parallel with disease progression in all these patients.

7. The downregulation of TXNDC5 could contribute to rheumatoid arthritis synovial fibroblasts antiangiogenic and proapoptotic features through suppression of CXCL10 and TRAIL.

8. Viperin (also known as radical SAM domain-containing 2 (RSAD2)) is expressed in differentiating chondrocytic cells and regulates their protein secretion and the outcome of chondrogenic differentiation by influencing transforming growth factor beta (TGF-beta)/SMAD family 2/3 (SMAD2/3) activity via C-X-C motif chemokine ligand 10 (CXCL10).

9. TNFalpha by itself has no effect on the secretion of CXCL10, whereas it increases dose-dependently the secretion of CXCL8 in Graves' thyrocytes, and in Grave's opthalmopathy fibroblasts and preadipocytes, while IFNgamma does stimulate the secretion of CXCL10 but it inhibits that of CXCL8. This differential modulation of CXCL10 and CXCL8 chemokines may reflect a different role of the two chemokines in the course of the ...

10. sCD163, CCL2, and CXCL10 are associated with activation of macrophages and may have a serious impact on overall survival in patients with idiopathic pulmonary fibrosis .

11. Expression of CXCL10 was up-regulated in hepatocellular carcinoma (HCC) tissues, expression of CXCR3 was down-regulated in HBV-related HCC tissues

12. results suggest that the CXCL10/CXCR3 axis may contribute to the pathogenesis of Behcet's disease

13. Suggest that a novel and functionally interdependent interplay between EZH2 and G9a regulates histone methylation-mediated epigenetic repression of the antifibrotic CXCL10 gene in idiopathic pulmonary fibrosis.

14. Studied role of chemokines (including C-X-C motif chemokine ligand 11 [CXCL11] and C-X-C motif chemokine ligand 10 [CXCL10] in the CXCR3 axis with regards to angiogenesis in adipose tissue of morbidly obese patients.

15. CXCL10 blood level is associated with tuberculosis in the HIV infected patients.

16. ur results showed that a fragment consisting of residues 196-413 in MERS-N is sufficient to up-regulate CXCL10, while the N-terminal domain and serine-arginine (SR)-rich motif of MERS-N do not play a role in this up-regulation.

17. A strong correlation between elevated serum levels of IP-10 and DPPIV activity was seen in different cholestatic patient groups.

18. The level of the serum IP-10 is higher in Chronic Hepatitis C patients compared to control group, and its level significantly decreased with effective antiviral treatment.

19. hepatocellular carcinoma patients with a high concentration of CXCL10 in the tumor microenvironment had significantly poorer overall survival and disease-free survival than those with lower CXCL10 expression levels

20. Inflammatory cytokines interleukin (IL)-1alpha, IL-1beta and interferon-gamma-induced protein (IP)-10 are biomarkers for detecting asymptomatic STIs and vaginal dysbiosis (bacterial vaginosis (BV) or intermediate microbiota).

Mouse (Murine) Chemokine (C-X-C Motif) Ligand 10 (CXCL10) interaction partners

1. The C5aR1- and TLR2-signalling pathways converge on the activation of p38 MAPK and the generation of C-X-C motif chemokine 10, which functions, among others, as an osteoclastogenic factor.

2. Viperin (also known as radical SAM domain-containing 2 (RSAD2)) is expressed in differentiating chondrocytic cells and regulates their protein secretion and the outcome of chondrogenic differentiation by influencing transforming growth factor beta (TGF-beta)/SMAD family 2/3 (SMAD2/3) activity via C-X-C motif chemokine ligand 10 (CXCL10).

3. Loss of CXCL10 is associated with Kidney Disease in Diabetes.

4. This work highlights CXCL10 as a downstream effector of type I IFN signaling and suggests a division of labor in pDCs subtypes that likely impacts their function as effectors of viral responses and as drivers of inflammation.

5. Study show that CXCL9 and CXCL10 are overexpressed in skin of HPV16 E7 transgenic mice when compared with non-transgenic animals. Immune cell infiltration to E7 transgenic skin is a consequence of epidermal hyperplasia, and that hyperplasia induces CXCL9 and CXCL10 production to recruit a subset of CXCR3+ T cells, promoting rejection of grafted E7 transgenic skin depleted of immunosuppressive lymphocytes.

6. Forced expression of CXCL10 prevents in vitro growth and metastasis of colon carcinoma cells by recruiting natural killer cells.

7. upregulated in synovium and chondrocytes following intra-articular fracture

8. FNDC4 could suppress osteoclast formation via NF-kappaB pathway and downregulation of CXCL10

9. This study explored the effect of CXCL10 on COPD induced by cigarette smoke (CS) and its underlying mechanism.

10. CXCL10, not CXCL9 or CXCL11, induced IL-9 expression in the liver tissue.

11. in vivo experiments show that the CXCL10/CXC chemokine receptor family 3 axis prevents the recruitment of macrophages, reduces inflammation, and halts the progression of the disease; the increased production of IL-1beta highlights the autoinflammatory nature of congenital hepatic fibrosis and may open novel therapeutic avenues

12. CXCL10 and blood-brain barrier permeability enhancement in rabies virus infection

13. Study shows that circulating interferon- that binds to receptors on brain endothelial cells and induces Cxcl10, is a central link in the signaling chain eliciting inflammation-induced aversion.

14. The knockout of either CXCL10 or TNF-alpha reduced germ cell apoptosis in the co-cultures of germ cells and Sertoli cells in response to MuV infection. Local injection of MuV into the testes of mice confirmed the involvement of CXCL10 in germ cell apoptosis in vivo.

15. CXCL10 has strong inhibitory effects on neovascularization, whereas MMP13 is required for neovascularization in C. albicans-infected corneas.

16. Study provided the evidence that CXCL10/CXCR3 signaling in periaqueductal gray is involved in the development of morphine analgesic tolerance via neuron-microglia interaction.

17. Results suggest that CXCL10(-/-) mice are protected against diet-induced nonalcoholic steatohepatitis (NASH), in an obesity-independent manner.

18. In conclusion, upregulated CXCL10 in steatohepatitis impairs autophagic flux by reducing autolysosome formation, thereby inhibiting autophagic protein degradation and the accumulation of ubiquitinated proteins, leading to the development of steatohepatitis.

19. These findings highlight the importance of CXCL10 signaling in the pathogenesis of rheumatoid arthritis and provide previously unidentified details of the mechanisms by which CXCL10 promotes the development of arthritis.

20. Study revealed that CXCL10 evoked an ionic current mainly carried by Cl(-) channels, suggests that Cl(-) channels are likely key molecular candidates responsible for the CXCL10-evoked neuronal activation and itch-like behaviors in a murine model of allergic contact dermatitis induced by the antigen squaric acid dibutylester. Cl(-) channels may emerge as a promising drug target for the treatment of allergic itch.

Cow (Bovine) Chemokine (C-X-C Motif) Ligand 10 (CXCL10) interaction partners

1. These results demonstrated that bovine colonic cells seem capable to respond to E. bovis merozoite I infection by the upregulation of CXCL10 and GM-CSF gene transcription.

2. IL-17A was shown to be upregulated, supporting its investigation as a potential biomarker of bTB.