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Finding demonstrated that miR-206 negatively regulated PCa cell proliferation and migration, and arrested cell cycle by targeting CXCL11 as a tumor suppressor in prostate cancer.
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V2O5 induction of CXCL8 and CXCL11 chemokines may lead to the appearance and perpetuation of an inflammatory reaction into the dermal tissue. Further studies are required to evaluate dermal integrity and manifestations in subjects occupationally exposed, or living in polluted areas.
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BK polyomavirus infection can induce CXCL11 gene expression in kidney transplant patients.
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CXCL11 production in cerebrospinal fluid was found in herpes simplex meningitis, but not in herpes simplex encephalitis.
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Neuroendocrine-like cells promote the chemotaxis activity of tumor-associated macrophages (TAM) via CXCL10 and CXCL11.
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High CXCL11 expression is associated with clear-cell renal cell carcinoma.
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CCL5 and CXCL11 expression were also induced in response to the activation of the PKC pathway, and gene silencing experiments indicated that their inducible expression was dependent on RIPK4 and IRF6. Moreover, gene reporter assays suggested that RIPK4 induces CCL5 and CXCL11 expression by stimulating the transactivation of their promoters by IRF6.
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data suggest that STAT2 plays a role in the psoriasis pathogenesis by regulating the expression of CXCL11 and CCL5, and thereby attracting IFNgamma-producing immune cells to the skin
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this study shows that melanoma peptides vaccination and intratumoral administration of IFNgamma increases production of CXCL11 in patient tumors
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S100A9 and S100A12 may have a role in the pathogenesis of pneumonia: S100A9 and CXCL1 may contribute solely in mild pneumonia, and CCL5 and CXCL11 may contribute in severe pneumonia.
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Downregulation of CXC chemokine ligand 11 can inhibit tumor angiogenesis, suggesting that anti-CXC chemokine ligand 11 therapy may offer an alternative treatment strategy for TWIST1-positive ovarian cancer
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CXCL8/11 may promote the disease progression of osteoarthritis (OA), and may also serve as new therapeutic targets for treatment of OA.
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this study shows that oxidative signaling inhibits T lymphocyte chemotaxis to the inflammatory chemokine CXCL11
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The homozygous variant CXCL11 AA genotype (rs6817952) is associated with an increased risk of contact allergy.
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In contrast to elevated 1st trimester levels of IP-10 previously found in the maternal serum of women who later developed preeclampsia, this study found lower umbilical cord IP-10 and ITAC plasma levels in near-term gestations with established severe preeclampsia.
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CXCL11 levels are mainly increased in patients with non-alcoholic cirrhosis and high portal pressure. Moreover, levels of CXCL11 might predict long-time survival of cirrhotic patients undergoing TIPS.
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higher concentration is associated with neutrophils accumulation in the alveolar space of Systemic Lupus Erythematosus patients with pulmonary fibrosis
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Developmental expression patterns of chemokines CXCL11, CXCL12 and their receptor CXCR7 in testes
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congruent with the concept that inflammation plays a key role in the pathogenesis of LV dysfunction, MIG, IP10 and I-TAC add diagnostic accuracy over and beyond NT-pro BNP.
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Resveratrol substantially inhibited the proinflammatory cytokines-induced CXCL11 production while partially blocking nuclear factor-kappaB activation.
