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CXCR3 encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Additionally we are shipping CXCR3 Kits (65) and CXCR3 Proteins (10) and many more products for this protein.
Showing 10 out of 331 products:
Human Monoclonal CXCR3 Primary Antibody for CyTOF, FACS - ABIN4899102
Falk, Singh, Faber, Nissen, Hviid, Sørensen: Dysregulation of CXCR3 expression on peripheral blood leukocytes in patients with neovascular age-related macular degeneration. in Investigative ophthalmology & visual science 2014
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Human Monoclonal CXCR3 Primary Antibody for FACS - ABIN4895558
Chihara, Aranami, Oki, Matsuoka, Nakamura, Kishida, Yokoyama, Kuroiwa, Hattori, Okamoto, Murata, Toda, Miyake, Yamamura: Plasmablasts as migratory IgG-producing cells in the pathogenesis of neuromyelitis optica. in PLoS ONE 2013
Show all 19 Pubmed References
Human Monoclonal CXCR3 Primary Antibody for FACS - ABIN4895564
Clay, Rodrigues, Harvey, Leutenegger, Esser: Distinct chemokine triggers and in vivo migratory paths of fluorescein dye-labeled T Lymphocytes in acutely simian immunodeficiency virus SIVmac251-infected and uninfected macaques. in Journal of virology 2005
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Mouse (Murine) Monoclonal CXCR3 Primary Antibody for FACS - ABIN4895552
Christensen, de Lemos, Moos, Christensen, Thomsen: CXCL10 is the key ligand for CXCR3 on CD8+ effector T cells involved in immune surveillance of the lymphocytic choriomeningitis virus-infected central nervous system. in Journal of immunology (Baltimore, Md. : 1950) 2006
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Human Polyclonal CXCR3 Primary Antibody for FACS, IF (p) - ABIN678653
Zhang, Fei, Gao, Liu, Zhang: The role of CXCR3 in the induction of primary biliary cirrhosis. in Clinical & developmental immunology 2011
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Mouse (Murine) Monoclonal CXCR3 Primary Antibody for CyTOF, FACS - ABIN4899101
Guarda, Hons, Soriano, Huang, Polley, Martín-Fontecha, Stein, Germain, Lanzavecchia, Sallusto: L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells. in Nature immunology 2007
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Mouse (Murine) Monoclonal CXCR3 Primary Antibody for FACS - ABIN4895544
Mackay, Rahimpour, Ma, Collins, Stock, Hafon, Vega-Ramos, Lauzurica, Mueller, Stefanovic, Tscharke, Heath, Inouye, Carbone, Gebhardt: The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin. in Nature immunology 2013
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Human Monoclonal CXCR3 Primary Antibody for FACS - ABIN1176889
Loetscher, Gerber, Loetscher, Jones, Piali, Clark-Lewis, Baggiolini, Moser: Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. in The Journal of experimental medicine 1997
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Human Monoclonal CXCR3 Primary Antibody for FACS, IHC - ABIN2689041
Piali, Weber, LaRosa, Mackay, Springer, Clark-Lewis, Moser: The chemokine receptor CXCR3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP10 and Mig. in European journal of immunology 1998
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Human Polyclonal CXCR3 Primary Antibody for IHC (fro), WB - ABIN4301162
Brambilla, Persaud, Hu, Karmally, Shestopalov, Dvoriantchikova, Ivanov, Nathanson, Barnum, Bethea: Transgenic inhibition of astroglial NF-kappa B improves functional outcome in experimental autoimmune encephalomyelitis by suppressing chronic central nervous system inflammation. in Journal of immunology (Baltimore, Md. : 1950) 2009
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High CXCR3 expression is associated with invasion and metastasis in tongue squamous cell carcinoma.
Up-regulated CXCR3 is detectable in the amniotic fluid and associated with the presence of placental lesions consistent with maternal anti-fetal rejection so may serve as a potential marker of spontaneous preterm delivery.
the expression of chemokine (show CCL1 Antibodies) receptors in different peripheral blood T-cell subsets in patients with polymyositis (PM) and dermatomyositis, was examined.
Results suggest that infiltration of chemokine (C-X-C motif) receptor 3 (CXCR3)-positive plasma cells is a characteristic feature of Hunner type interstitial cystitis (HIC (show MDFIC Antibodies)).
Results of this study indicate that CXCR3 overexpression in GC is associated with increased DC and TIL (show TLR1 Antibodies) infiltration and improved OS.
Following activation with T-cell receptor and co-culture with various concentrations of chrysotile fibers using freshly isolated CD4 (show CD4 Antibodies)+ surface CXCR3 positive and negative fractions, the intracellular expression of CXCR3, IFNgamma and IL-17 (show IL17A Antibodies) remained unchanged when co-cultured with chrysotile.
In conclusion, it seems that decreased expression of CXCR3 and higher expression of CCR6 (show CCR6 Antibodies) were associated with HTLV-1 infection, what indicate that these alterations may favor virus dissemination but not disease manifestation.
Alternatively spliced variant of CXCR3 mediates the metastasis of liver cancer.
The CXCL4 (show PF4 Antibodies) monomer acts as the minimal active unit for interacting with CXCR3 N-Terminal Sulfated (show SULF1 Antibodies) Peptide, and sulfation of N-terminal tyrosine residues on the receptor is important for binding.
approach has been able to describe the structural events which dynamically characterize the molecular mechanisms involved in the binding of CXCR3 to CXCL11 (show CXCL11 Antibodies) and the critical role exerted by its N-terminal region in "hunting" and capturing the ligand.
The data of this study suggested that spinal CXCR3 mediates chronic itch and alloknesis, and targeting CXCR3 may provide effective treatment for chronic pruritus.
Study provided the evidence that CXCL10 (show CXCL10 Antibodies)/CXCR3 signaling in periaqueductal gray is involved in the development of morphine analgesic tolerance via neuron-microglia interaction.
The results demonstrate that the recruitment of peripheral immune cells into the CNS, induction of neuroinflammation, and consecutive weight loss during herpes encephalitis is modulated by CXCR3 signaling.
results show an important role for CXCR3 and CXCL10 (show CXCL10 Antibodies) in the tissue distribution of preimmune memory phenotype CD8 (show CD8A Antibodies) T- cells
Our data suggests that the altered gene profiles induced by CXCR3 deficiency promotes autoimmune cholangitis through pathogenic CD8 (show CD8A Antibodies)(+) T cells.
Data suggest that the CXCL9 (show CXCL9 Antibodies)-CXCR3 axis plays a pivotal role in the liver-specific distribution of TRAIL+ NK cells in mice.
ATF3 (show ATF3 Antibodies)-KO mice escape from PE-dependent maladaptive cardiac remodeling by suppressing the IFNgamma-CXCL10 (show CXCL10 Antibodies)-CXCR3 axis at multiple levels.
study thus shows that lung mucosal-resident memory T cells are not generated following systemic TB immunization and that local inflammation is required for systemically activated T cells to home to lung mucosa, which is mediated by interaction between CXCR3 upregulated in these cells and its ligands IP-10 (show CXCL10 Antibodies) and MIG (show CXCL9 Antibodies)
Antigen targeting to DEC-205 (show LY75 Antibodies) on dendritic cells leads to an IL-10 (show IL10 Antibodies)-dependent downregulation of CXCR3 expression on differentiated antigen-specific Th1 (show HAND1 Antibodies) cells in vivo. This downregulation interferes with the migration of Th1 (show HAND1 Antibodies) cells into the gut (show GUSB Antibodies) and protects mice against severe acute and relapsing intestinal inflammation.
this study shows that neutrophils and NK cells act as important disease-promoting immune cells in experimental osteoarthritis and their functional interaction is promoted by the CXCL10 (show CXCL10 Antibodies)/CXCR3 axis
Transcript analysis showed that antigen stimulation of WC1(+)gammadelta T cells substantially increased CXCR3 expression
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716).
chemokine (C-X-C motif) receptor 3
, C-X-C chemokine receptor type 3
, G protein-coupled receptor 9
, IP-10 receptor
, IP10 receptor
, Mig receptor
, chemokine (C-X-C) receptor 3
, interferon-inducible protein 10 receptor
, CXC chemokine receptor 3
, Interferon-inducible protein 10 receptor