anti-Chemokine (C-X-C Motif) Receptor 3 (CXCR3) Antibodies

CXCR3 encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Additionally we are shipping CXCR3 Kits (64) and CXCR3 Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CXCR3 2833 P49682
CXCR3 12766 O88410
CXCR3 84475 Q9JII9
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Top anti-CXCR3 Antibodies at antibodies-online.com

Showing 10 out of 202 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB Anti-CXCR3 Picoband antibody,  IHC(P): Human Lung Cancer Tissue Anti-CXCR3 Picoband antibody,  All lanes: Anti-CXCR3 at 0.5ug/ml Lane 1: Colo320 Whole Cell Lysate at 40ug Lane 2: SGC Whole Cell Lysate at 40ug Predicted bind size: 41KD Observed bind size: 41KD 100 μg 4 to 6 Days
$280.00
Details
Human Goat Un-conjugated ELISA, FACS, IF   100 μg 6 to 7 Days
$429.84
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of CD183 staining in human muscle formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of CD183 expression in K562 (A) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from K562 cells, using CXCR3 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB CXCR3 Antibody (Center) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. CXCR3 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CXCR3 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated IHC, WB 100 μL 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated FACS, IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat exfoliated cells labeled with Anti-CXCR3 Polyclonal Antibody, Unconjugated (ABIN678653) at 1:200 followed by conjugation to the secondary antibody and DAB staining HCCLM3 cells probed with Rabbit Anti-CXCR3 Polyclonal Antibody, Unconjugated  ) at 1:100 for 30 minutes followed by incubation with a conjugated secondary -FITC) (green) for 30 minutes compared to control cells (blue), secondary only (light blue) and isotype control (orange). 100 μL 3 to 7 Days
$329.45
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Anti-CXCR3 antibody IHC staining of human brain, cortex neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN959303 concentration 10 ug/ml. 50 μL 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated IHC, IHC (p) Anti-CXCR3 antibody  ABIN1048474 IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of Mouse heart lysate, using CXCR3 Antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6277370 at 1/100 staining Mouse kidney tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL 11 to 12 Days
$390.77
Details

Top referenced anti-CXCR3 Antibodies

  1. Human Monoclonal CXCR3 Primary Antibody for CyTOF, FACS - ABIN4899102 : Falk, Singh, Faber, Nissen, Hviid, Sørensen: Dysregulation of CXCR3 expression on peripheral blood leukocytes in patients with neovascular age-related macular degeneration. in Investigative ophthalmology & visual science 2014 (PubMed)
    Show all 30 Pubmed References

  2. Human Monoclonal CXCR3 Primary Antibody for FACS - ABIN4895564 : Clay, Rodrigues, Harvey, Leutenegger, Esser: Distinct chemokine triggers and in vivo migratory paths of fluorescein dye-labeled T Lymphocytes in acutely simian immunodeficiency virus SIVmac251-infected and uninfected macaques. in Journal of virology 2005 (PubMed)
    Show all 19 Pubmed References

  3. Human Monoclonal CXCR3 Primary Antibody for FACS - ABIN4895558 : Chihara, Aranami, Oki, Matsuoka, Nakamura, Kishida, Yokoyama, Kuroiwa, Hattori, Okamoto, Murata, Toda, Miyake, Yamamura: Plasmablasts as migratory IgG-producing cells in the pathogenesis of neuromyelitis optica. in PLoS ONE 2013 (PubMed)
    Show all 19 Pubmed References

  4. Mouse (Murine) Monoclonal CXCR3 Primary Antibody for FACS - ABIN4895552 : Christensen, de Lemos, Moos, Christensen, Thomsen: CXCL10 is the key ligand for CXCR3 on CD8+ effector T cells involved in immune surveillance of the lymphocytic choriomeningitis virus-infected central nervous system. in Journal of immunology (Baltimore, Md. : 1950) 2006 (PubMed)
    Show all 9 Pubmed References

  5. Mouse (Murine) Polyclonal CXCR3 Primary Antibody for IHC (fro), IP - ABIN549475 : Ye, Bu, Guo, Shu, Wang, Guan, Yang, Tian, Xiang, Gao: Activation of CXCL10/CXCR3 signaling attenuates morphine analgesia: involvement of Gi protein. in Journal of molecular neuroscience : MN 2014 (PubMed)
    Show all 5 Pubmed References

  6. Human Polyclonal CXCR3 Primary Antibody for FACS, IF (p) - ABIN678653 : Zhang, Fei, Gao, Liu, Zhang: The role of CXCR3 in the induction of primary biliary cirrhosis. in Clinical & developmental immunology 2011 (PubMed)
    Show all 5 Pubmed References

  7. Mouse (Murine) Monoclonal CXCR3 Primary Antibody for FACS - ABIN4895544 : Mackay, Rahimpour, Ma, Collins, Stock, Hafon, Vega-Ramos, Lauzurica, Mueller, Stefanovic, Tscharke, Heath, Inouye, Carbone, Gebhardt: The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin. in Nature immunology 2013 (PubMed)
    Show all 4 Pubmed References

  8. Mouse (Murine) Monoclonal CXCR3 Primary Antibody for CyTOF, FACS - ABIN4899101 : Guarda, Hons, Soriano, Huang, Polley, Martín-Fontecha, Stein, Germain, Lanzavecchia, Sallusto: L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells. in Nature immunology 2007 (PubMed)
    Show all 4 Pubmed References

  9. Human Polyclonal CXCR3 Primary Antibody for IHC (fro), IP - ABIN549476 : Segerer: The role of chemokines and chemokine receptors in progressive renal diseases. in American journal of kidney diseases : the official journal of the National Kidney Foundation 2003 (PubMed)
    Show all 3 Pubmed References

  10. Human Monoclonal CXCR3 Primary Antibody for FACS, IHC - ABIN2689041 : Piali, Weber, LaRosa, Mackay, Springer, Clark-Lewis, Moser: The chemokine receptor CXCR3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP10 and Mig. in European journal of immunology 1998 (PubMed)
    Show all 3 Pubmed References

More Antibodies against CXCR3 Interaction Partners

Human Chemokine (C-X-C Motif) Receptor 3 (CXCR3) interaction partners

  1. CXCR3 and its chemokines are involved in the recruitment of granulocytes and mononuclear cells, therefore in the maintenance of inflammation in Crohn disease

  2. In primary biliary cirrhosis (PBC), circulating MIG levels and CXCR3+ cells are related with the progression of the disease; their expression increases significantly in PBC patients with respect to controls

  3. Expression of CXCL10 was up-regulated in hepatocellular carcinoma (HCC) tissues, expression of CXCR3 was down-regulated in HBV-related HCC tissues

  4. results suggest that the CXCL10/CXCR3 axis may contribute to the pathogenesis of Behcet's disease

  5. miR-16-5p can protect LPS-induced A549 cell injury, and its mechanism may be related to the targeted regulation of CXCR3

  6. The result of this study showed that CXCR3/CXCL10/CXCL11 signaling axis is overexpressed in the small intestinal mucosa of celiac disease patients compared to controls. This finding might explain the specific enrollment of the main cell populations that infiltrate the epithelium

  7. Study found a respectively increased and decreased expression of CXCR3 splice variants CXCR3A and CXCR3B in colorectal cancer (CRC) tumors. CXCR3A and CXCR3B played disparate roles in regulating progressive characteristics of CRC cells, including the proliferation, invasion, migration, and tumorigenicity. This study suggests that the alternation of CXCR3 splice isoforms is necessary in the metastasis of CRC.

  8. Study suggests that vitiligo is likely to be initiated in the normal-appearing skin of vitiligo subjects through activation of local innate lymphocyte-induced melanocyte apoptosis and subsequent activation of adaptive and memory immune responses. This apoptosis is mediated by melanocytic CXCR3B, identifying this isoform of CXCR3 chemokine receptor to be critical in melanocyte destruction and initiation of the disease.

  9. Study shows that the expression level of CXCR3 in T cells was significantly elevated in several neurological diseases. Study reviews evidence that CXCR3 plays a vital role in the pathogenesis of multiple sclerosis, glioma, Alzheimer disease, chronic pain, human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis and bipolar disorder.

  10. Increased CXCR3 expression is associated with progression of primary open-angle glaucoma.

  11. IL1B promotes the transendothelial migration of mesenchymal stem cells through CXCR3-CXCL9 axis.

  12. Study found that vitiligo skin is enriched with CD8 resident memory T cells that express CXCR3. Strikingly, a higher frequency of skin melanocyte-specific CD8 T cells was found within the CXCR3+ subset.

  13. The populations were identified based on the production of IFN-gamma and/or IL-17 and the coexpression of CXCR3 (X3) and CCR6 (R6).

  14. High CXCR3 expression is associated with invasion and metastasis in tongue squamous cell carcinoma.

  15. Up-regulated CXCR3 is detectable in the amniotic fluid and associated with the presence of placental lesions consistent with maternal anti-fetal rejection so may serve as a potential marker of spontaneous preterm delivery.

  16. the expression of chemokine receptors in different peripheral blood T-cell subsets in patients with polymyositis (PM) and dermatomyositis, was examined.

  17. Results suggest that infiltration of chemokine (C-X-C motif) receptor 3 (CXCR3)-positive plasma cells is a characteristic feature of Hunner type interstitial cystitis (HIC).

  18. Results of this study indicate that CXCR3 overexpression in GC is associated with increased DC and TIL infiltration and improved OS.

  19. Following activation with T-cell receptor and co-culture with various concentrations of chrysotile fibers using freshly isolated CD4+ surface CXCR3 positive and negative fractions, the intracellular expression of CXCR3, IFNgamma and IL-17 remained unchanged when co-cultured with chrysotile.

  20. In conclusion, it seems that decreased expression of CXCR3 and higher expression of CCR6 were associated with HTLV-1 infection, what indicate that these alterations may favor virus dissemination but not disease manifestation.

Mouse (Murine) Chemokine (C-X-C Motif) Receptor 3 (CXCR3) interaction partners

  1. Results suggest that CXCR3 confers early protection against S. typhimurium infection which is crucial in preventing bacterial dissemination to the spleen and liver of mice. Both the early recruitment of CXCR3-expressing neutrophils and CXCR3-mediated IFN-gamma secretion are instrumental in an effective immune response against gram-negative S. typhimurium.

  2. Salmonella enterica (Se) infection stimulates robust expansion of chemokine (C-X-C motif) receptor 3 (CXCR3+) Th1 cells.

  3. Further analysis revealed that IRF1 deficiency suppress interferon-gamma production and delayed CD8+ T cell proliferation. CXCR3 expression was found to be decreased in pathogenic CD8+ T cells, which limited their migration to the brain

  4. CXCR3-deficient mesenchymal stem cells did not ameliorate lupus symptoms in MRL. Fas(lpr) mice in comparison with wild-type mesenchymal stem cells. The data suggest that upregulation of CXCR3 in mesenchymal stem cells will be a good strategy to increase their infiltration into the kidney in mice, which will improve therapeutic outcomes in systemic lupus erythematosus (SLE).

  5. The data illustrate the paradoxical pro-tumor role for CXCR3 in lung immunobiology wherein the CXCR3 axis drives both the anti-tumor effector cell chemoattraction and pro-tumor infiltration of the lungs and suggests a potential therapeutic target for lung-tropic metastasizing cancers.

  6. the data suggest that CXCR3 and the integrin alpha4 mediate T cell recruitment to uninfected salivary glands but that redundant mechanisms mediate T cell recruitment after Murine Cytomegalovirus infection.

  7. The data of this study suggested that spinal CXCR3 mediates chronic itch and alloknesis, and targeting CXCR3 may provide effective treatment for chronic pruritus.

  8. Study provided the evidence that CXCL10/CXCR3 signaling in periaqueductal gray is involved in the development of morphine analgesic tolerance via neuron-microglia interaction.

  9. The results demonstrate that the recruitment of peripheral immune cells into the CNS, induction of neuroinflammation, and consecutive weight loss during herpes encephalitis is modulated by CXCR3 signaling.

  10. results show an important role for CXCR3 and CXCL10 in the tissue distribution of preimmune memory phenotype CD8 T- cells

  11. Our data suggests that the altered gene profiles induced by CXCR3 deficiency promotes autoimmune cholangitis through pathogenic CD8(+) T cells.

  12. Data suggest that the CXCL9-CXCR3 axis plays a pivotal role in the liver-specific distribution of TRAIL+ NK cells in mice.

  13. ATF3-KO mice escape from PE-dependent maladaptive cardiac remodeling by suppressing the IFNgamma-CXCL10-CXCR3 axis at multiple levels.

  14. study thus shows that lung mucosal-resident memory T cells are not generated following systemic TB immunization and that local inflammation is required for systemically activated T cells to home to lung mucosa, which is mediated by interaction between CXCR3 upregulated in these cells and its ligands IP-10 and MIG

  15. Antigen targeting to DEC-205 on dendritic cells leads to an IL-10-dependent downregulation of CXCR3 expression on differentiated antigen-specific Th1 cells in vivo. This downregulation interferes with the migration of Th1 cells into the gut and protects mice against severe acute and relapsing intestinal inflammation.

  16. this study shows that neutrophils and NK cells act as important disease-promoting immune cells in experimental osteoarthritis and their functional interaction is promoted by the CXCL10/CXCR3 axis

  17. These results demonstrate a critical role for both BLT1 and CXCR3 in cytotoxic T lymphocyte (CTL) migration to tumors and thus may be targeted to enhance efficacy of CTL-based immunotherapies.

  18. Our studies suggest that CXCR3 is a key contributor to the pathogenesis of Alopecia areata by mediating the infiltration of autoreactive CD8+NKG2D+ T cells into the skin

  19. Cxcr3 is up-regulated by DNA demethylation and interaction with C/EBPalpha which contributes to neuropathic pain.

  20. These findings demonstrate that the CXCL10/CXCR3 chemokine pathway is critical in shaping CD8(+) T cell immunity, locally within latently infected tissues, which protects against recurrent herpesvirus infection and disease.

Cow (Bovine) Chemokine (C-X-C Motif) Receptor 3 (CXCR3) interaction partners

  1. Transcript analysis showed that antigen stimulation of WC1(+)gammadelta T cells substantially increased CXCR3 expression

Zebrafish Chemokine (C-X-C Motif) Receptor 3 (CXCR3) interaction partners

  1. The demonstration of a conserved CXCR3-CXCL11 signaling axis in zebrafish extends the translational applicability of this model for studying diseases involving the innate immune system.

CXCR3 Antigen Profile

Protein Summary

This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716).

Gene names and symbols associated with CXCR3

  • C-X-C motif chemokine receptor 3 (CXCR3) antibody
  • chemokine (C-X-C motif) receptor 3 (Cxcr3) antibody
  • chemokine (C-X-C motif) receptor 3 (cxcr3) antibody
  • C-X-C motif chemokine receptor 3 (Cxcr3) antibody
  • chemokine (C-X-C motif) receptor 3, tandem duplicate 1 (cxcr3.1) antibody
  • CD182 antibody
  • Cd183 antibody
  • CKR-L2 antibody
  • Cmkar3 antibody
  • CXC-R3 antibody
  • CXCR-3 antibody
  • cxcr3 antibody
  • Gpr9 antibody
  • IP10-R antibody
  • Mig-R antibody
  • MigR antibody
  • sb:eu378 antibody

Protein level used designations for CXCR3

C-X-C chemokine receptor type 3 , CXC-R3 , CXCR-3 , G protein-coupled receptor 9 , IP-10 receptor , IP10 receptor , Mig receptor , chemokine (C-X-C) receptor 3 , interferon-inducible protein 10 receptor , chemokine (C-X-C motif) receptor 3 , CXC chemokine receptor 3 , Interferon-inducible protein 10 receptor , CXCR3ab , chemokine (C-X-C motif) receptor 3.1 , dr-chr16-CXCR3-41.8%-EK27498 , dr-chr16-CXCR3-41.8-EK27498

GENE ID SPECIES
2833 Homo sapiens
12766 Mus musculus
465704 Pan troglodytes
491952 Canis lupus familiaris
496477 Xenopus (Silurana) tropicalis
497018 Bos taurus
699438 Macaca mulatta
84475 Rattus norvegicus
100860874 Capra hircus
654692 Danio rerio
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