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CCBP2 encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors.
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Data show the structural motifs in the atypical chemokine receptor 2 (ACKR2) are responsible for ligand binding, and suggest ACKR2-derived N-terminal peptides as being of potential therapeutic significance.
engagement of the ACR (show ACR Proteins) D6 by its ligands activates a beta (show SUCLA2 Proteins)-arrestin1 (show ARRB1 Proteins)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein (show KPTN Proteins) cofilin (show CFL1 Proteins) through the Rac1-PAK1 (show PAK1 Proteins)-LIMK1 (show LIMK1 Proteins) cascade.
co-expression of DARC (show DARC Proteins), D6, and CCX-CKR (show CCRL1 Proteins) significantly associated with higher survival in gastric cancer
CCL2 binding to primary adult human astrocytes is CCR2-independent and is likely to be mediated via the D6 decoy.
D6 is expressed in AMs (show MAT1A Proteins) from patients with COPD, and its expression correlates with the degree of functional impairment and markers of immune activation.
Chemokine (show CCL1 Proteins) decoy receptor D6 limits CC-chemokine (show CCL1 Proteins)-dependent pathogenic inflammation and is required for adequate cardiac remodeling after myocardial infarction.
DARC (show DARC Proteins) and D6, the most studied members of this group of molecules, are reviewed.
CCR10 (show CCR10 Proteins) is unlikely to be necessary for cutaneous homing of TH cells in the models studied here. CCR10 (show CCR10 Proteins) may instead play a role in the movement of specialized "effector" cutaneous TH cells to and/or within epidermal microenvironments.
CCR10 and its mucosal epithelial ligand CCL28 have roles in the migration of circulating IgA plasmablasts
ACKR2 (Ccbp2) is a key regulator of myeloid differentiation and function and its targeting unleashes the anti-metastatic activity of neutrophils.
study found that the inflammatory chemokine (show CCL1 Proteins) CCL5 (show CCL5 Proteins) is mostly retained (75%) during the resolution of zymosan A peritonitis in mice; CCL5 (show CCL5 Proteins) exerts a novel proresolving role on macrophages when acting in concert with apoptotic PMN (show TBCE Proteins)-expressed D6.
Further examination revealed that proximity of pro-lymphangiogenic macrophages to developing lymphatic vessel surfaces is increased in ACKR2-deficient mice and reduced in CCR2-deficient mice.
some cells, including plasmacytoid dendritic cells, can express both CCR2 (show CCR2 Proteins) and ACKR2; that Ly6C(high) monocytes have particularly strong CCL2 (show CCL2 Proteins)-scavenging potential in vitro and in vivo; and that CCR2 (show CCR2 Proteins) is a much more effective CCL2 (show CCL2 Proteins) scavenger than ACKR2.
control of CCR2 ligands by D6 regulates the traffic of Ly6C(high) monocytes and controls their immunosuppressive potential.
D6, by suppressing inflammatory chemokine (show CCL1 Proteins) binding to lymphatic surfaces, and thereby preventing inflammatory leukocyte adherence, is a regulator of lymphatic function and a contributor to the integration of innate and adaptive immune responses.
identify novel D6(active) B1-cell subsets, including those we term B1d, which lack CD5 (show CD5 Proteins) and CD11b (show ITGAM Proteins) but exhibit typical B1-cell properties, including spontaneous ex vivo production of IgM (show CD40LG Proteins), IL-10 (show IL10 Proteins), and anti-phosphorylcholine antibody
the chemokine (show CCL1 Proteins) scavenger receptor D6 has a non-redundant role in acute toxic liver injury in vivo; results support the importance of post-translational chemokine (show CCL1 Proteins) regulation and describe a new mechanism of immune modulation within the liver
This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members\; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.
C-C chemokine receptor D6
, CC-chemokine-binding receptor JAB61
, chemokine (C-C motif) receptor 9
, chemokine (C-C) receptor 9
, chemokine binding protein 2
, chemokine receptor CCR-10
, chemokine receptor CCR-9
, chemokine receptor D6
, chemokine-binding protein 2
, chemokine-binding protein D6
, CCR10-related receptor
, D6 beta-chemokine receptor