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Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. Additionally we are shipping Chitinase 3-Like 1 (Cartilage Glycoprotein-39) Kits (77) and Chitinase 3-Like 1 (Cartilage Glycoprotein-39) Proteins (25) and many more products for this protein.
Showing 10 out of 114 products:
Human Monoclonal CHI3L1 Primary Antibody for ELISA - ABIN2472953
Iwarson: [The pattern of non-A, non-B hepatitis is more and more evident. A new test for diagnosis of hepatitis C makes it possible to mass screen blood donors]. in Läkartidningen 1990
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Cow (Bovine) Polyclonal CHI3L1 Primary Antibody for IF, WB - ABIN2784693
Ober, Tan, Sun, Possick, Pan, Nicolae, Radford, Parry, Heinzmann, Deichmann, Lester, Gern, Lemanske, Nicolae, Elias, Chupp: Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. in The New England journal of medicine 2008
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CHI3L1 may be a previously unrecognized biomarker for diagnosing Gaucher Diseases (GD) and for evaluating the therapeutic effects of new GD drug.
CHI3L1 deficiency in donor splenocytes dramatically increased the severity of aGVHD through enhancing Tfh cell differentiation
miR (show MLXIP Antibodies)-24 serves as a molecular regulator in S. aureus-induced macrophage polarization through targeting of CHI3L1 and regulation of the MAPK (show MAPK1 Antibodies) pathway
The mouse model was used to validate the function of CHI3L1 in cancer metastasis in vivo
CHI3L1-mediated cell proliferation/survival involves partial downregulation of the pro-apoptotic S100A9 (show S100A9 Antibodies) protein that is highly expressed during the acute phase of colitis, by binding to the S100A9 (show S100A9 Antibodies) receptor, RAGE (show AGER Antibodies) (Receptor for Advanced Glycation End products).
IL-18 (show IL18 Antibodies) is a potent stimulator of Chi3l1 and that Chi3l1 is an important mediator of IL-18 (show IL18 Antibodies)-induced inflammatory, fibrotic, alveolar remodeling, and cytotoxic responses.
CHI3L1 is induced during fungal infection, and it regulated antifungal innate immune responses in the cornea.
Astrocytic expression of chitinase 3-like protein 1 limits the extent of both astrocytic and microglial/macrophage facets of neuroinflammation.
Results do not support a role of BRP (show GDF5 Antibodies)-39 in the pathogenesis of experimental autoimmune encephalitis.
CHI3L1 was increased in plasma and brain tissue in experimental cerebral malaria, but targeted Chi3l1 deletion did not alter cytokine production or survival in this model.
Plasma YKL-40 distinguishes between patients with features of asthma-chronic obstructive pulmonary disorder (COPD (show ARCN1 Antibodies)) overlap (ACO (show KLK15 Antibodies)) and COPD (show ARCN1 Antibodies) patients.
CHI3L1 expression is a novel biomarker for the prognosis of gastric cancer and these findings have thus identified CHI3L1/CD44 (show CD44 Antibodies) axis as a vital pathway and potential therapeutic target in gastric cancer
Gene expressions of YKL-40 and CD36 (show CD36 Antibodies) were significantly higher in patients with T2DM (>5 yr) with hypertension compared to healthy controls (P=0.006). In addition, a significant increase in serum levels of sCD36, PPAR-gamma (show PPARG Antibodies) and YKL-40 was observed in patients with T2DM (>5 yr) with hypertension compared to healthy controls
YKL-40 was highly elevated in patients with ESRD on HD, and dialysis reduced serum YKL-40 concentrations approximately one-sixth. YKL-40 measured after dialysis was independently associated with mortality in HD patients.
Review/Meta-analysis: YKL-40 may be implicated in bronchial inflammation and remodeling in COPD (show ARCN1 Antibodies) and may be considered as a useful biomarker for COPD (show ARCN1 Antibodies) diagnosis and monitoring.
YKL-40 is a glycoprotein - a potential marker for active inflammatory process - with proven predictive value in a number of diseases that evolve with inflammation, remodeling of the extracellular matrix, or development of fibrosis.
TMEM219 plays a critical role in Chi3l1-induced IL-13Ralpha2 mediated signalling and tissue responses.
Our present data reveal the crucial role of CHI3L1 in the formation of vasculogenic mimicry, which may contribute to tumour aggressiveness of cervical cancer
there was a negative correlation between YKL-40 and TLR4 (show TLR4 Antibodies) expression in chronic sinusitis patients with nasal polyps. YKL-40 and TLR4 (show TLR4 Antibodies) interacted with each other to activate NF-kappaB (show NFKB1 Antibodies) and promote disease progression.
chitinase-like lectin, YKL-40, binds specifically to type I collagen and modulates the rate of type I collagen fibril formation
Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling.
, cartilage glycoprotein 39
, chitinase-3-like protein 1
, 39 kDa synovial protein
, 38 kDa heparin-binding glycoprotein
, signal-processing protein
, 39 kDa whey protein
, 40 kDa secretory signalling glycoprotein
, cartilage glycoprotein-39
, chitinase-like protein 1
, signal processing protein
, chitinase 3-like 1 protein
, mammary gland protein 40