anti-Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1) Antibodies

Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. Additionally we are shipping Chitinase 3-Like 1 (Cartilage Glycoprotein-39) Kits (35) and Chitinase 3-Like 1 (Cartilage Glycoprotein-39) Proteins (25) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CHI3L1 12654 Q61362
CHI3L1 1116 P36222
CHI3L1 89824 Q9WTV1
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Top anti-Chitinase 3-Like 1 (Cartilage Glycoprotein-39) Antibodies at

Showing 10 out of 96 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated IF, WB WB Suggested Anti-CHI3L1 Antibody Titration: 0.2-1 ug/mlPositive Control: HepG2 cell lysate 100 μL 2 to 3 Days
Human Rabbit Un-conjugated WB Western blot analysis of YKL-40 expression in HEK293T (A), Raw264.7 (B), H9C2 (C) whole cell lysates. 200 μL 13 to 14 Days
Mouse Rabbit Un-conjugated ELISA, WB Western blot analysis of CHI3L1 using anti-CHI3L1 antibody . Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.  Lane 1: mouse RAW264.7 whole cell lysates, Lane 2: mouse HEPA1-6 whole cell lysates. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-CHI3L1 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 ug/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for CHI3L1 at approximately 43KD. The expected band size for CHI3L1 is at 43KD. 100 μg 4 to 6 Days
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Human Serum. 100 μg 13 to 16 Days
Human Rabbit Un-conjugated IHC, IHC (p), WB 100 μL 11 to 14 Days
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of extracts of TPH1 , using CHI3L1 antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6277469 at 1/100 staining Mouse colon tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL 11 to 12 Days
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extract of various cells, using CHI3L1 antibody. 100 μL 11 to 13 Days
Human Rabbit Un-conjugated FACS, IF (p), IHC (p) HepG2 cells probed with Rabbit Anti-CHI3L1 Polyclonal Antibody  Alexa Fluor 488 Secondary 100 μL 14 to 21 Days
Human Rabbit FITC ICC, IF, IHC, WB 100 μg 13 to 16 Days
Mouse Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot;1: Mouse Liver Tissue; 2: Mouse Lung Tissue;3:Mouse Spleen Tissue. 100 μg 13 to 16 Days

Top referenced anti-Chitinase 3-Like 1 (Cartilage Glycoprotein-39) Antibodies

  1. Human Monoclonal CHI3L1 Primary Antibody for ELISA, WB - ABIN534878 : Bonneh-Barkay, Bissel, Wang, Fish, Nicholl, Darko, Medina-Flores, Murphey-Corb, Rajakumar, Nyaundi, Mellors, Bowser, Wiley: YKL-40, a marker of simian immunodeficiency virus encephalitis, modulates the biological activity of basic fibroblast growth factor. in The American journal of pathology 2008 (PubMed)
    Show all 2 Pubmed References

  2. Human Monoclonal CHI3L1 Primary Antibody for ELISA - ABIN2472953 : Iwarson: [The pattern of non-A, non-B hepatitis is more and more evident. A new test for diagnosis of hepatitis C makes it possible to mass screen blood donors]. in Läkartidningen 1990 (PubMed)
    Show all 4 Pubmed References

  3. Cow (Bovine) Polyclonal CHI3L1 Primary Antibody for IF, WB - ABIN2784693 : Ober, Tan, Sun, Possick, Pan, Nicolae, Radford, Parry, Heinzmann, Deichmann, Lester, Gern, Lemanske, Nicolae, Elias, Chupp: Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. in The New England journal of medicine 2008 (PubMed)
    Show all 2 Pubmed References

More Antibodies against Chitinase 3-Like 1 (Cartilage Glycoprotein-39) Interaction Partners

Mouse (Murine) Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1) interaction partners

  1. The authors found that USF1 induced miR-125a-3p levels which suppressed Chi3L1 expression. Their results suggest that lung metastasis is suppressed by knock-down of Chi3L1 through miR-125a-3p-mediated up-regulation of USF1.

  2. Chi3l1 is a regulator of Th1 and CTL which could be a therapeutic target to enhance anti-tumor immunity.

  3. Nrf2/Keap1 system regulates VSMC apoptosis during neointimal formation, thereby inhibiting neointimal hyperplasia after a vascular injury.

  4. Knockdown of Chi3l1 in the arterial endothelium suppressed the development of atherosclerosis in amyloid precursor protein transgenic mice.

  5. CHI3L1 may be a previously unrecognized biomarker for diagnosing Gaucher Diseases (GD) and for evaluating the therapeutic effects of new GD drug.

  6. CHI3L1 deficiency in donor splenocytes dramatically increased the severity of aGVHD through enhancing Tfh cell differentiation

  7. miR-24 serves as a molecular regulator in S. aureus-induced macrophage polarization through targeting of CHI3L1 and regulation of the MAPK pathway

  8. The mouse model was used to validate the function of CHI3L1 in cancer metastasis in vivo

  9. CHI3L1-mediated cell proliferation/survival involves partial downregulation of the pro-apoptotic S100A9 protein that is highly expressed during the acute phase of colitis, by binding to the S100A9 receptor, RAGE (Receptor for Advanced Glycation End products).

  10. IL-18 is a potent stimulator of Chi3l1 and that Chi3l1 is an important mediator of IL-18-induced inflammatory, fibrotic, alveolar remodeling, and cytotoxic responses.

  11. CHI3L1 is induced during fungal infection, and it regulated antifungal innate immune responses in the cornea.

  12. Astrocytic expression of chitinase 3-like protein 1 limits the extent of both astrocytic and microglial/macrophage facets of neuroinflammation.

  13. Results do not support a role of BRP-39 in the pathogenesis of experimental autoimmune encephalitis.

  14. CHI3L1 was increased in plasma and brain tissue in experimental cerebral malaria, but targeted Chi3l1 deletion did not alter cytokine production or survival in this model.

  15. mechanism of BRP-39 in bleomycin-induced pulmonary fibrosis

  16. Sem7a and its receptors regulate Chi3l1 in pulmonary melanoma metastasis

  17. Data show that IL-1-induced transcriptin factor RelB/NF-kappa B p50 Subunit complex formation was further promoted by oncostatin M and that these complexes directly bound to the secreted protein cartilage glycoprotein 39 (YKL-40) promoter.

  18. These results indicate that catalytically inactive BRP-39 and Ym1 are constitutive genes in normal mouse lung.

  19. BRP-39 is involved in repressing the M1 proinflammatory phenotype in hyperoxia, thereby deactivating inflammatory responses in macrophages and preventing neonatal lung injury.

  20. Chi3l1 binds to IL-13Ralpha2, stimulates MAPK, Akt/PKB, Wnt signaling and regulates melanoma metastasis.

Human Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1) interaction partners

  1. CHI3L1 promoted cancer cell proliferation by regulating cell cycles; CHI3L1 promoted cancer cell invasion and metastasis; CHI3L1 regulate liver cancer potentially by regulating the TGF-b signaling pathways

  2. Overall, this study identifies candidate changes in secreted proteins from NF1 deficient glioma cells that could influence the tumor microenvironment, and suggests a direct link between NF1 loss and increased tumor cell production of CHI3L1 and endoglin, two factors implicated in mesenchymal identity in glioblastoma.

  3. Shrimp Antiviral mja-miR-35 Targets CHI3L1 in Human M2 Macrophages and Suppresses Breast Cancer Metastasis.

  4. genotype consisting of the cis-eQTL allele that reduces expression of CHI3L1 was specifically associated with late-onset adult asthma

  5. hese findings highlight the importance of periostin and YKL40 as serum biomarkers for assessment of asthma severity and acute asthma exacerbations in children with asthma.

  6. The differential expression of the immunomodulatory molecule YKL-40/CHI3L1 may affect the treatment efficacy of PI3K/AKT-based pathway inhibitors in glioblastoma.

  7. High serum Level of YKL-40 is associated with large bowel adenoma.

  8. The effects of CHI3L1 genetic variation on circulating YKL-40 levels are partly mediated by methylation profiles. In our study YKL-40 levels, but not CHI3L1 SNPs or methylation levels, were associated with childhood asthma.

  9. YKL-40 is over-expressed in the cerebral cavernous malformation endothelium and acts as an angiogenic factor that promotes the pathogenesis of sporadic cerebral cavernous malformation

  10. plasma YKL-40 could be a potential biomarker for early diagnosis of incipient diabetic nephropathy among South Indian population

  11. the association between YKL-40 expression in epicardial adipose tissue (EAT) and atrial fibrosis in patients with atrial fibrillation, was investigated.

  12. CHI3L1 could be used as a preliminary tool to differentiate mild/absent fibrosis from significant fibrosis and cirrhosis.

  13. A statistically significant positive correlation of CHI3L1 and Nogo-A expression (r=0.474, p>0.0001) and a positive correlation of Nogo-A and VEGFC expression (r=0.280, p=0.013) were found. CHI3L1 and Nogo-A are important in angiogenesis in invasive ductal breast carcinoma

  14. CHI3L1 ameliorates LPS-induced atherosclerotic reactions via PPARdelta-mediated suppression of inflammation and ER stress.

  15. YKL-40 is associated with bone turnover in obstructive sleep apnea.

  16. After adjusting cognitive scores by age, anxiety and EDSS, association was detected between CHI3L1 levels and Trail Making Test A and between NF-L levels and Word List Generation

  17. This study showed that the use of serum YKL-40 levels as a blood biomarker of neutrophilic airway and systemic inflammation, which overlap in Th2 cytokine-dominant bronchial asthma, enabled easy evaluation of one of the characteristics of COPD that overlaps with bronchial asthma.

  18. YKL-40 but not PSA serum levels are higher in patients with baseline resistance to docetaxel; YKL40 may be related to bone metastasis and shorter survival

  19. CF neutrophils have higher intracellular level of YKL-40 than neutrophils from healthy volunteers, but they do not release more YKL-40 when stimulated with exogenous stimulus. These results suggest that the increased levels of circulating YKL-40 in CF patients might originate from another cellular source.

  20. YKL-40 elevation significantly improved risk prediction for all-cause and cardiovascular mortality in hemodialysis patients.

Cow (Bovine) Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1) interaction partners

  1. Two 2-methylpentane-2,4-diol molecules are bound at subsites -2 and -1, inducing a rare obstructive conformation of Trp78 and twisting of the side chains of Glu269 and Ile272.

  2. chitinase-like lectin, YKL-40, binds specifically to type I collagen and modulates the rate of type I collagen fibril formation

Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1) Antigen Profile

Protein Summary

Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling.

Gene names and symbols associated with CHI3L1

  • chitinase-like 1 (Chil1) antibody
  • chitinase 3 like 1 (CHI3L1) antibody
  • chitinase 3-like 1 (cartilage glycoprotein-39) (CHI3L1) antibody
  • chitinase 3 like 1 (Chi3l1) antibody
  • ASRT7 antibody
  • AW208766 antibody
  • BP40 antibody
  • Brp39 antibody
  • CGP-39 antibody
  • Chil1 antibody
  • CLP-1 antibody
  • GP-39 antibody
  • GP38K antibody
  • GP39 antibody
  • HC-gp39 antibody
  • HCGP-3P antibody
  • hCGP-39 antibody
  • MGP-40 antibody
  • SPC-40 antibody
  • SPS-40 antibody
  • YKL-40 antibody
  • YKL40 antibody
  • YYL-40 antibody

Protein level used designations for CHI3L1

CGP-39 , GP-39 , cartilage glycoprotein 39 , chitinase-3-like protein 1 , 39 kDa synovial protein , 38 kDa heparin-binding glycoprotein , signal-processing protein , 39 kDa whey protein , 40 kDa secretory signalling glycoprotein , cartilage glycoprotein-39 , chitinase-like protein 1 , signal processing protein , chitinase 3-like 1 protein , mammary gland protein 40

12654 Mus musculus
1116 Homo sapiens
396865 Sus scrofa
286869 Bos taurus
89824 Rattus norvegicus
100860825 Capra hircus
443279 Ovis aries
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