Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1) ELISA Kits

Mouse (Murine) Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1) interaction partners

1. Chi3l1 is a regulator of Th1 and CTL which could be a therapeutic target to enhance anti-tumor immunity.

2. Nrf2/Keap1 system regulates VSMC apoptosis during neointimal formation, thereby inhibiting neointimal hyperplasia after a vascular injury.

3. Knockdown of Chi3l1 in the arterial endothelium suppressed the development of atherosclerosis in amyloid precursor protein transgenic mice.

4. CHI3L1 may be a previously unrecognized biomarker for diagnosing Gaucher Diseases (GD) and for evaluating the therapeutic effects of new GD drug.

5. CHI3L1 deficiency in donor splenocytes dramatically increased the severity of aGVHD through enhancing Tfh cell differentiation

6. miR-24 serves as a molecular regulator in S. aureus-induced macrophage polarization through targeting of CHI3L1 and regulation of the MAPK pathway

7. The mouse model was used to validate the function of CHI3L1 in cancer metastasis in vivo

8. CHI3L1-mediated cell proliferation/survival involves partial downregulation of the pro-apoptotic S100A9 protein that is highly expressed during the acute phase of colitis, by binding to the S100A9 receptor, RAGE (Receptor for Advanced Glycation End products).

9. IL-18 is a potent stimulator of Chi3l1 and that Chi3l1 is an important mediator of IL-18-induced inflammatory, fibrotic, alveolar remodeling, and cytotoxic responses.

10. CHI3L1 is induced during fungal infection, and it regulated antifungal innate immune responses in the cornea.

11. Astrocytic expression of chitinase 3-like protein 1 limits the extent of both astrocytic and microglial/macrophage facets of neuroinflammation.

12. Results do not support a role of BRP-39 in the pathogenesis of experimental autoimmune encephalitis.

13. CHI3L1 was increased in plasma and brain tissue in experimental cerebral malaria, but targeted Chi3l1 deletion did not alter cytokine production or survival in this model.

14. mechanism of BRP-39 in bleomycin-induced pulmonary fibrosis

15. Sem7a and its receptors regulate Chi3l1 in pulmonary melanoma metastasis

16. Data show that IL-1-induced transcriptin factor RelB/NF-kappa B p50 Subunit complex formation was further promoted by oncostatin M and that these complexes directly bound to the secreted protein cartilage glycoprotein 39 (YKL-40) promoter.

17. These results indicate that catalytically inactive BRP-39 and Ym1 are constitutive genes in normal mouse lung.

18. BRP-39 is involved in repressing the M1 proinflammatory phenotype in hyperoxia, thereby deactivating inflammatory responses in macrophages and preventing neonatal lung injury.

19. Chi3l1 binds to IL-13Ralpha2, stimulates MAPK, Akt/PKB, Wnt signaling and regulates melanoma metastasis.

20. Stat3 downstream gene product chitinase 3-like 1 is elevated in lung cancer

Human Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1) interaction partners

1. plasma YKL-40 could be a potential biomarker for early diagnosis of incipient diabetic nephropathy among South Indian population

2. the association between YKL-40 expression in epicardial adipose tissue (EAT) and atrial fibrosis in patients with atrial fibrillation, was investigated.

3. CHI3L1 could be used as a preliminary tool to differentiate mild/absent fibrosis from significant fibrosis and cirrhosis.

4. A statistically significant positive correlation of CHI3L1 and Nogo-A expression (r=0.474, p>0.0001) and a positive correlation of Nogo-A and VEGFC expression (r=0.280, p=0.013) were found. CHI3L1 and Nogo-A are important in angiogenesis in invasive ductal breast carcinoma

5. CHI3L1 ameliorates LPS-induced atherosclerotic reactions via PPARdelta-mediated suppression of inflammation and ER stress.

6. YKL-40 is associated with bone turnover in obstructive sleep apnea.

7. After adjusting cognitive scores by age, anxiety and EDSS, association was detected between CHI3L1 levels and Trail Making Test A and between NF-L levels and Word List Generation

8. This study showed that the use of serum YKL-40 levels as a blood biomarker of neutrophilic airway and systemic inflammation, which overlap in Th2 cytokine-dominant bronchial asthma, enabled easy evaluation of one of the characteristics of COPD that overlaps with bronchial asthma.

9. YKL-40 but not PSA serum levels are higher in patients with baseline resistance to docetaxel; YKL40 may be related to bone metastasis and shorter survival

10. CF neutrophils have higher intracellular level of YKL-40 than neutrophils from healthy volunteers, but they do not release more YKL-40 when stimulated with exogenous stimulus. These results suggest that the increased levels of circulating YKL-40 in CF patients might originate from another cellular source.

11. YKL-40 elevation significantly improved risk prediction for all-cause and cardiovascular mortality in hemodialysis patients.

12. Polymorphisms of the CHI3L1 gene (rs4950928 C>G and rs10399931 C>T) are associated with the risk and prognosis of AD and can affect the expression of CHI3L1 in plasma.

13. High YKL-40 expression is associated with endothelial cell angiogenesis in breast cancer.

14. Pretreatment serum levels of YKL-40 may be a novel prognostic factor of overall and disease-free survival in patients with nonmetastatic colorectal cancer

15. Plasma YKL-40 distinguishes between patients with features of asthma-chronic obstructive pulmonary disorder (COPD) overlap (ACO) and COPD patients.

16. CHI3L1 expression is a novel biomarker for the prognosis of gastric cancer and these findings have thus identified CHI3L1/CD44 axis as a vital pathway and potential therapeutic target in gastric cancer

17. Gene expressions of YKL-40 and CD36 were significantly higher in patients with T2DM (>5 yr) with hypertension compared to healthy controls (P=0.006). In addition, a significant increase in serum levels of sCD36, PPAR-gamma and YKL-40 was observed in patients with T2DM (>5 yr) with hypertension compared to healthy controls

18. YKL-40 was highly elevated in patients with ESRD on HD, and dialysis reduced serum YKL-40 concentrations approximately one-sixth. YKL-40 measured after dialysis was independently associated with mortality in HD patients.

19. Review/Meta-analysis: YKL-40 may be implicated in bronchial inflammation and remodeling in COPD and may be considered as a useful biomarker for COPD diagnosis and monitoring.

20. YKL-40 is a glycoprotein - a potential marker for active inflammatory process - with proven predictive value in a number of diseases that evolve with inflammation, remodeling of the extracellular matrix, or development of fibrosis.

Cow (Bovine) Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1) interaction partners

1. Two 2-methylpentane-2,4-diol molecules are bound at subsites -2 and -1, inducing a rare obstructive conformation of Trp78 and twisting of the side chains of Glu269 and Ile272.

2. chitinase-like lectin, YKL-40, binds specifically to type I collagen and modulates the rate of type I collagen fibril formation