Chloride Channel Kb Proteins (CLCNKB)

The protein encoded by CLCNKB is a member of the family of voltage-gated chloride channels. Additionally we are shipping CLCNKB Antibodies (62) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat CLCNKB CLCNKB 79430 P51802
CLCNKB 1188 P51801
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Top CLCNKB Proteins at

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 60 to 65 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg 60 to 65 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days

CLCNKB Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,

More Proteins for Chloride Channel Kb (CLCNKB) Interaction Partners

Mouse (Murine) Chloride Channel Kb (CLCNKB) interaction partners

  1. Loss of ClC-K2 compromises TAL function and abolishes salt reabsorption in the distal convoluted tubule. Our data suggest that ClC-K2 is crucial for renal salt reabsorption and concentrating ability. ClC-K2-deficient mice in most aspects mimic patients with Bartter's syndrome type 3.

  2. Through the combined effects of pHi and pHo on ClC-K2, might be a key regulator of NaCl absorption.

  3. IGF-1, by stimulating ClC-K2 channels, promotes net Na(+) and Cl(-) reabsorption, thus reducing driving force for potassium secretion by the cortical collecting duct.

Human Chloride Channel Kb (CLCNKB) interaction partners

  1. Taking advantage of the largest number of functional results of CLCNKB mutations, we reveal the functionally important domains and severe mutational spots of the hClC-Kb channel and establish the genotype-phenotype association in classic Bartter's Syndrome.

  2. Five patients had 1 or more mutations in CLCNKB, of whom 3 had homozygous mutations and 2 had single heterozygous mutations and only in CLCNKB had hypocalciuria.

  3. Single loci of tag Single Nucleotide Polymorphisms of CLCNKA_B are not enough to increase the Essential Hypertension susceptibility, the combination of CLCNKA SNP, salt, marine products, meat, edible oil consumption is associated with elevated risk

  4. results demonstrate that the carboxyl terminus of hClC-Kb is not part of the binding site for barttin, but functionally modifies the interplay with barttin.

  5. These results demonstrate that mutations in a cluster of hydrophobic residues within transmembrane domain 1 affect barttin-CLC-K interaction and impair gating modification by the accessory subunit

  6. we report here for the first time that ClC-Kb disease-causing mutations located around the selectivity filter can result in both reduced surface expression and hyperactivity in heterologous expression systems

  7. Case Report: 2 mutations in the CLCNKB gene, leading to a molecular diagnosis of Bartter syndrome type III in case of sudden infant death.

  8. R8W and G47R, two naturally occurring barttin mutations identified in patients with Bartter syndrome type IV, reduce barttin palmitoylation and CLC-K/barttin channel activity.

  9. HEK293 cells the potentiating effect of niflumic acid (NFA) on CLC-Ka/barttin and CLC-Kb/barttin channels seems to be absent while the blocking efficacy of niflumic acid and benzofuran derivatives observed in oocytes is preserved

  10. study investigated the functional consequences of seven mutations; four mutants carried no current whereas others displayed a 30-60 percent reduction in conductance as compared with wild-type ClC-Kb

  11. expands the association between CLCNKB and essential hypertension to a non-European ancestry population

  12. This article presents the case of a patient with hypokalaemia caused by CLCNKB gene mutation hard to categorise as GS or BS type 3.

  13. CLCNKB mutations are associated with Bartter syndrome.

  14. novel missense variant of the CLCNKB gene in two patients with type III Bartter syndrome

  15. there was no significant association between the SLC12A3 R904Q variant and the ClC-Kb-T481S variant and essential hypertension in Mongolian and Han populations in Inner Mongolia

  16. four mutations in the CLCNKB gene, among patients suffering from bartter and Gitelman syndromes

  17. Identify a protein region that is involved in calcium binding and that is likely undergoing conformational changes underlying the complex gating of CLC-K channels.

  18. Three novel CLCNKB mutations are identified associated with classic Bartter syndrome with a role in altering the functional properties of ClC-Kb channels.

  19. DNA mutational analysis of CLCNKB in Bartter syndrome type 3.

  20. presence of Gitelman and Bartter syndrome and CBS phenotypes, in a kindred with the CLCNKB R438H mutation.

Xenopus laevis Chloride Channel Kb (CLCNKB) interaction partners

  1. The open probability and mean open time of ClC-2 was voltage dependent, decreasing dramatically as the patches were depolarized. ClC-2 is uniquely suitable to promote anion secretion with little anion reabsorption.

CLCNKB Protein Profile

Protein Summary

The protein encoded by this gene is a member of the family of voltage-gated chloride channels. Chloride channels have several functions, including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. This gene is expressed predominantly in the kidney and may be important for renal salt reabsorption. Mutations in this gene are associated with autosomal recessive Bartter syndrome type 3 (BS3). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Chloride Channel Kb Proteins (CLCNKB)

  • chloride voltage-gated channel Kb (CLCNKB)
  • chloride channel Kb (CLCNKB)
  • chloride channel, voltage-sensitive Kb (Clcnkb)
  • chloride voltage-gated channel Kb (Clcnkb)
  • chloride channel, voltage-sensitive Kb L homeolog (clcnkb.L)
  • chloride channel K (clcnk)
  • chloride channel protein ClC-Ka (LOC100017912)
  • chloride channel protein ClC-Kb (LOC100400180)
  • chloride channel protein ClC-Kb (LOC100590605)
  • chloride channel protein ClC-Kb (LOC100730738)
  • ClC-k protein
  • ClC-K2 protein
  • ClC-K2L protein
  • Clc-Ka protein
  • clc-kb protein
  • Clck2 protein
  • clckb protein
  • Clcnk1l protein
  • CLCNKA protein
  • clcnka-A protein
  • Clcnkb protein
  • clk-k2 protein
  • DKFZp469N0132 protein
  • x6clck protein
  • xCIC-K protein
  • xClC-K protein
  • zgc:64141 protein

Protein level used designations for Chloride Channel Kb Proteins (CLCNKB)

chloride channel Kb , chloride channel Ka , chloride channel K1-like; putative basolateral cTAL chloride channel ClC-Ka , chloride channel protein ClC-Kb , clC-K2 , putative basolateral mTAL chloride channel ClC-Ka , chloride channel K2 , chloride channel, kidney, B , CIC-K , chloride channel protein ClC-Kb-like , chloride channel, voltage-sensitive Kb

703476 Macaca mulatta
428190 Gallus gallus
456470 Pan troglodytes
100171573 Pongo abelii
56365 Mus musculus
79430 Rattus norvegicus
1188 Homo sapiens
378616 Xenopus laevis
393353 Danio rerio
100017912 Monodelphis domestica
100400180 Callithrix jacchus
100590605 Nomascus leucogenys
100730738 Cavia porcellus
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