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Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume.
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After CLIC1 knockdown, the expression levels of ITGalpha3, ITGalphav, ITGbeta1 and Bcl-2 (show BCL2 ELISA Kits) mRNA and protein were decreased significantly in gastric cancer cells, as well as AKT (show AKT1 ELISA Kits)-phosphorylation, ERK (show EPHB2 ELISA Kits)-phosphorylation and p38 (show CRK ELISA Kits)-phosphorylation, were reduced in vivo.
The current study provides the first statistically convincing evidence that downregulation of miR (show MLXIP ELISA Kits)-372 may occur in gallbladder cancer tissues, which may be associated with aggressive and progressive tumor behavior by affecting CLIC1 expression.
The CLIC1-mediated drug resistance is achieved through positive regulation of MRP1 (show MDM4 ELISA Kits) in choriocarcinoma.CLIC1 is highly expressed in chemoresistant choriocarcinoma.
Proteomic analysis indicates that CLIC1 promotes tumorgenesis in epithelial ovarian cancer.
CLIC1 is a possible tumor marker for ovarian cancer. Dendritic cells pulsed with MtHsp70 (show HSPA9 ELISA Kits)-CLIC1 can enhance antitumor immunity against ovarian cancer, providing a novel immune therapeutic strategy.
Either dysfunction or downregulation of CLIC1 can partially decrease the antineoplastic effects of metformin.
The expression of CLIC1 might be closely related to the carcinogenesis, clinical biological behaviors, and prognosis of pancreatic ductal adenocarcinomas.
Extracellular vesicle-mediated transfer of CLIC1 protein is a novel mechanism for the regulation of glioblastoma growth.
Results indicate that CLIC1 is an important contributor to tumor invasion, metastasis, and angiogenesis.
CLIC1 acts as a putative oncogene (show RAB1A ELISA Kits) in pancreatic cancer.
Results indicate CLICs (CLIC1, CLIC4 (show CLIC4 ELISA Kits) and CLIC5 (show CLIC5 ELISA Kits))-dependent chloride efflux as an essential and proximal upstream event for NLRP3 (show NLRP3 ELISA Kits) activation.
We conclude that the role of CLIC1 in macrophage superoxide production is to support redistribution of NADPH oxidase (show NOX1 ELISA Kits) to the plasma membrane, and not through major effects on ERM cytoskeleton or by acting as a plasma membrane chloride channel (show CLCA1 ELISA Kits).
Data, including data from studies in primary cells from knockout mice, suggest Clic1 and Clic4 (show CLIC4 ELISA Kits) participate in signaling interleukin 1beta secretion and in activation of Nlrp3 (show NLRP3 ELISA Kits) inflammasomes; in LPS (show TLR4 ELISA Kits) macrophage activation, Clic1 and Clic4 (show CLIC4 ELISA Kits) are translocated to nucleus/cell membranes. (Clic1 = chloride intracellular channel 1; Clic4 (show CLIC4 ELISA Kits) = chloride intracellular channel 4 (show CLIC4 ELISA Kits), mitochondrial; Nlrp3 (show NLRP3 ELISA Kits) = NLR family pyrin domain containing 3 (show NLRP3 ELISA Kits))
This study demonstrates for the first time that CLIC1 is overexpressed during AS development both in vitro and in vivo and can regulate the accumulation of inflammatory cytokines and production of oxidative stress.
Clic1 have a role in migration and invasion in hepatocarcinoma maybe via modulating the expression of Annexin A7 (show ANXA7 ELISA Kits) and Gelsolin (show GSN ELISA Kits).
These data all point to an important role for CLIC1 in regulating macrophage function through its ion channel activity.
The down-regulation of CLIC1 enhanced proliferative activity.
CLIC1 may play an important role in tumor metastasis.
CLIC1 is essential for the proliferation and invasion of hepatocellular carcinoma cells.
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family\; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.
chloride intracellular channel 1
, RNCC protein
, chloride channel ABP
, chloride intracellular channel protein 1
, nuclear chloride ion channel 27
, nuclear chloride ion channel protein
, regulatory nuclear chloride ion channel protein