anti-Chromodomain Helicase DNA Binding Protein 2 (CHD2) Antibodies

The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. Additionally we are shipping and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CHD2 1106 O14647
CHD2 244059  
CHD2 308738  
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Top anti-CHD2 Antibodies at antibodies-online.com

Showing 10 out of 49 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-CHD2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  721_B cell lysate CHD2 is supported by BioGPS gene expression data to be expressed in 721_B Host:  Rabbit  Target Name:  CHD2  Sample Type:  Human Fetal Muscle  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of CHD2 expression in HEK293T (A), A549 (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of CHD2 using anti-CHD2 antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: human HepG2 whole Cell lysate.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-CHD2 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for CHD2 at approximately 211KD. The expected band size for CHD2 is at 211KD. IHC analysis of CHD2 using anti-CHD2 antibody . CHD2 was detected in paraffin-embedded section of rat brain tissue . Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti-CHD2 Antibody  overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1022) with DAB as the chromogen. 100 μg Log in to see 4 to 6 Days
$280.00
Details
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: CHD2 Sample Type: Ovary tumor lysates Antibody Dilution: 1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p) Human Prostate (formalin-fixed, paraffin-embedded) stained with CHD2 antibody ABIN214301 at 20 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-CHD2 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunohistochemistry: CHD2 Antibody [NBP2-32563] - Immunohistochemical staining of human cerebral cortex shows strong nuclear positivity in neuronal cells. Immunohistochemistry: CHD2 Antibody [NBP2-32563] - liver 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Rabbit Un-conjugated IHC, IHC (p), IP, WB Immunohistochemistry-Paraffin: CHD2 Antibody [NBP1-33428] - Paraffin-embedded SW480 Xenograft, using antibody at 1:100 dilution. Western Blot: CHD2 Antibody [NBP1-33428] - Sample (30 ug of whole cell lysate) A: Molt-4 7.5% SDS PAGE; antibody diluted at 1:1000. 0.1 mL Log in to see 8 to 11 Days
$514.63
Details
Human Rabbit Un-conjugated EIA, IHC (p) 50 μg Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated IF, WB Western Blot analysis of CHD2 expression in transfected 293T cell line by CHD2 MaxPab polyclonal antibody.<br><br>Lane 1: CHD2 transfected lysate(55.11 KDa).<br>Lane 2: Non-transfected lysate.<br> Immunofluorescence of <u>purified</u> MaxPab antibody to CHD2 on HeLa cell. [antibody concentration 10 ug/ml] 50 μL Log in to see 11 to 12 Days
$440.00
Details

CHD2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , , ,
,

Mouse (Murine)


Rat (Rattus) , ,


More Antibodies against CHD2 Interaction Partners

Human Chromodomain Helicase DNA Binding Protein 2 (CHD2) interaction partners

  1. Germline mosaicism resulted in a CHD2 gene missense variant and the development of autism spectrum disorder in two siblings.

  2. study reports monozygotic twins with a global neurodevelopmental delay associated with an autism spectrum disorder, hypotonia, postnatal microcephaly, stereotypic movements and circadian rhythm alterations in association with late-onset epilepsy; identified a CHD2 mutation, previously described in association with a phenotypic spectrum overlapping our patients' phenotype

  3. Results indicate a PARP1 (show PARP1 Antibodies)-dependent mechanism that regulates non-homologous end-joining through localized chromatin expansion and deposition of the histone variant H3.3 by CHD2 at DNA breaks promoting DNA repair.

  4. CHD2 mutations are responsible in rare cases for generalized epilepsy with myoclonic-atonic seizures.

  5. CHD2 is a cancer driver and has a role as chromatin remodeler in chronic lymphocytic leukemia.

  6. CHD2 mutation is the first identified cause of the archetypal generalized photosensitive epilepsy syndrome

  7. CHD1 (show CHD1 Antibodies) and CHD2 act as positive regulators of HIV-1 gene expression.

  8. The phenotypic spectrum of CHD2 encephalopathy has distinctive features of myoclonic epilepsy with marked photosensitivity.

  9. Human CHD2 is a chromatin assembly ATPase (show DNAH8 Antibodies) regulated by its chromatin- and DNA-binding domains.

  10. Our findings suggest that CHD2 mutations are important in the etiological spectrum of Lennox-Gastaut syndrome.

Mouse (Murine) Chromodomain Helicase DNA Binding Protein 2 (CHD2) interaction partners

  1. Chd2 is essential in preventing suppressive chromatin formation for developmentally regulated genes and determines subsequent effects on developmental processes in the undifferentiated state.

  2. inactivation of CHD2 during neurogenesis might contribute to abnormal neurodevelopment

  3. The data indicated that MyoD determines cell fate and facilitates differentiation- dependent gene expression through Chd2-dependent deposition of H3.3 at myogenic loci prior to differentiation.

  4. Study present evidence that the Chd2 mutant cells are defective in their ability to repair DNA damage induced by ionizing and ultraviolet radiation.

  5. Our results demonstrate that mutation of Chd2 dramatically affects mammalian development and long-term survival.

  6. Chd2 heterozygous mutant mice exhibit increased extramedullary hematopoiesis and susceptibility to lymphomas.

  7. Chd2-mutant mice present with glomerulopathy, proteinuria, and significantly impaired kidney function.

CHD2 Antigen Profile

Protein Summary

The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Gene names and symbols associated with CHD2

  • microRNA 3175 (MIR3175) antibody
  • chromodomain helicase DNA binding protein 2 (CHD2) antibody
  • chromodomain helicase DNA binding protein 2 (Chd2) antibody
  • 2810013C04Rik antibody
  • 2810040A01Rik antibody
  • 5630401D06Rik antibody
  • AI851092 antibody
  • BC029703 antibody
  • CHD2 antibody
  • DKFZp469E1718 antibody
  • EEOC antibody
  • MGC148727 antibody
  • MGC159952 antibody

Protein level used designations for CHD2

chromodomain helicase DNA binding protein 2 , ATP-dependent helicase CHD2 , CHD-2 , chromodomain-helicase-DNA-binding protein 2

GENE ID SPECIES
415507 Gallus gallus
453666 Pan troglodytes
535026 Bos taurus
100049803 Equus caballus
100174351 Pongo abelii
100550760 Meleagris gallopavo
1106 Homo sapiens
479028 Canis lupus familiaris
244059 Mus musculus
308738 Rattus norvegicus
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