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CHD5 encodes a member of the chromodomain helicase DNA-binding protein family.
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Data show that chromodomain helicase DNA binding protein 5 (CHD5) acted as a functional tumor suppressor and was frequently silenced by promoter CpG methylation in renal cell carcinoma (RCC (show XRCC1 ELISA Kits)).
CHD5 may act as a tumor suppressor gene in NSCLC.
Authors identified the CHD5 as a direct target of miR-454. CHD5 was downregulated in HCC tissues and cell lines and the expression level of CHD5 was inversely correlated with the expression of miR-454 in HCC tissues.
Data show a mutual suppression regulation between chromodomain helicase DNA binding protein 5 (CHD5) and enhancer of zeste homolog 2 (EZH2 (show EZH2 ELISA Kits), which may provide new insights into their potential therapeutic significance for hepatocellular carcinoma (HCC).
CHD5 methylation of rectal cancer has a great effect in influencing its clinical and pathological features.
Study shows that CHD5 is a Nucleosome remodeling and deacetylase complex-associated transcriptional repressor and identifies WEE1 (show WEE1 ELISA Kits) as one of the CHD5-regulated genes that may link CHD5 to tumor suppression.
Low CHD5 expression activates the DNA damage response and predicts poor outcome in patients undergoing adjuvant therapy for resected pancreatic cancer.
CHD5 is a potential tumour suppressor gene epigenetically silenced in hepatocellular carcinoma.
The tumor suppressor chromodomain helicase DNA-binding protein 5 (CHD5) remodels nucleosomes by unwrapping.
repression of CHD5 gene expression in human leukemia is mediated in part by DNA methylation of its promoter.
Pyramidal neurons cultured from Chd5(-/-) cortex displayed alterations in dendritic morphology. Paralleling autism spectrum disorder nosology, Chd5(-/-) mice exhibited abnormal sociocommunicative behavior and a strong preference for familiarity. Chd5(-/-) mice further showed deficits in responding to the distress of a conspecific, a mouse homolog of empathy.
Chd5 represses murine endogenous retrovirus-L (MuERV-L/MERVL), an endogenous retrovirus-derived retrotransposon, by regulating H3K27me3 and H3.1/H3.2 function.
Chd5 is a multi-faceted mediator of histone-to-protamine replacement and is important in the cascade of molecular events underlying this process of extensive chromatin remodelling.
Our data indicate that CHD5 is required for normal spermiogenesis, especially for spermatid chromatin condensation.
Chd5 expression is retained at high levels in differentiated neurons of the adult mouse.
These findings provide insights into the regulatory role of CHD5 during neurogenesis and suggest how inactivation of this candidate tumor suppressor might contribute to neuroblastoma.
Chd5 binds the unmodified N terminus of H3 through its tandem plant homeodomains (PHDs).
CHD5 regulates expression of neuronal genes, cell cycle genes and remodeling genes, and is linked to regulation of genes implicated in aging and Alzheimer's disease.
the association of between miR (show MLXIP ELISA Kits)-211-regulated CHD5 expression and CHD5 function in colorectal tumorigenesis
This gene encodes a member of the chromodomain helicase DNA-binding protein family. Members of this family are characterized by a chromodomain, a helicase ATP-binding domain and an additional functional domain. This gene encodes a neuron-specific protein that may function in chromatin remodeling and gene transcription. This gene is a potential tumor suppressor gene that may play a role in the development of neuroblastoma.
ATP-dependent helicase CHD5
, chromodomain-helicase-DNA-binding protein 5
, chromodomain helicase DNA binding protein 5
, Coronary heart disease, susceptibility to, 5
, chromodomain-helicase-DNA-binding protein 5-like