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CHGB encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. Additionally we are shipping CHGB Antibodies (50) and CHGB Proteins (17) and many more products for this protein.
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Mouse (Murine) CHGB ELISA Kit for Sandwich ELISA - ABIN649192
Fanara, Wong, Husted, Liu, Liu, Kohlstaedt, Riiff, Protasio, Boban, Killion, Killian, Epling, Sinclair, Peterson, Price, Cabin, Nussbaum, Brühmann, Brandt, Christine, Aminoff, Hellerstein: Cerebrospinal fluid-based kinetic biomarkers of axonal transport in monitoring neurodegeneration. in The Journal of clinical investigation 2012
Show all 2 Pubmed References
This analysis of mice lacking Cgs highlights the important roles of CgA and CgB in glucose and cardiovascular homeostasis. This study also unveils the existence of direct implications of Cgs in the control of behaviour and mood.
Chromogranin B contributes to a highly efficient system that directly mediates monoamine accumulation and exocytosis in large dense core secretory vesicles.
C-terminal domain of chromogranin B regulates intracellular calcium signaling.
CgB is not required for normal insulin (show INS ELISA Kits) granule biogenesis or maintenance in vivo, but is essential for adequate secretion of islet hormones
Chromogranin B gene ablation reduces the catecholamine cargo and decelerates exocytosis in chromaffin secretory vesicles in mice.
CGB was localized in the nucleus; transcription control role of CGB in the nucleus
These data suggest that RAGE (show AGER ELISA Kits) signaling is capable of driving neuronal differentiation involving CREB (show CREB1 ELISA Kits) activation and induction of chromogranin expression.
Chromogranin B has a role in secretory granule biogenesis
CGB may play an important modulatory role in the control of Ca2 (show CA2 ELISA Kits)+ release from the endoplasmic reticulum
Neuroendocrine-specific expression of Chgb is mediated by the CRE and G/C boxes in cis (show CISH ELISA Kits) and the transcription factors CREB (show CREB1 ELISA Kits), AP-2 (show TFAP2A ELISA Kits), Egr-1 (show EGR1 ELISA Kits) and Sp1 (show SP1 ELISA Kits).
results presented here suggest that CHGB variant alleles, the rare CHGB-L413 and common CHGB-P413, may act as modifiers of ALS (show IGFALS ELISA Kits) disease dependent on their expression levels which is higher in females because of a sex-determining region Y (show SRY ELISA Kits) element in the CHGB gene promoter.
Compared with chromogranin A (show CHGA ELISA Kits), chromogranin B may be more useful during proton pump inhibitor treatment and can detect tumors without liver metastases.
our results suggest that genetic variants of CHGB may have sex-specific effects on the risk of schizophrenia and provide useful preliminary information for further study.
Data indicate that measurement of chromogranin A (CgA (show CHGA ELISA Kits)) alone is sufficient in the management of patients with neuroendocrine tumours (NETs) and that routine additional measurement of chromogranin B (CgB) provides little added value.
intracellular calcium binding protein (show CETN1 ELISA Kits) Sg1 (show ZNF750 ELISA Kits) is increased in early multiple sclerosis (MS) patients compared to relapsing-remitting MS and neurological controls.
The polymorphism P413L in the CHGB gene was not associated with sporadic amyotrophic lateral sclerosis in a group of Italian patients.
CgA (show CGA ELISA Kits) and CgB (show CGB ELISA Kits) have been used as general NEN biomarkers for many years, while CART has only recently been identified
A heterogeneous response to short- and long-term physical activities among circulating granin proteins, particularly chromogranin B.
CgA (show CGA ELISA Kits), CgB (show CGB ELISA Kits), and secretoneurin (show SCG2 ELISA Kits) are detectable in feces, and collagenous colitis patients express higher values than patients with inflammatory bowel disease and controls. In treatment, fecal secretoneurin (show SCG2 ELISA Kits) decreased to control levels in collagenous colitis.
Our findings suggest that altered PTEN, ATRX (show ATRX ELISA Kits), CHGA (show CHGA ELISA Kits), and CHGB expression are associated with aggressive PNET phenotype in VHL (show VHL ELISA Kits) and may serve as useful adjunct prognostic markers to Ki-67 (show MKI67 ELISA Kits) in PNETs.
chromogranin B has a role in the IP(3)-mediated Ca(2 (show CA2 ELISA Kits)+) release mechanism of secretory granules
colocalization of all three inositol 1,4,5-trisphosphate receptor (IP(3)R (show ITPR1 ELISA Kits))isoforms with chromogranin B to the extent that the majority of each IP(3)R (show ITPR1 ELISA Kits) isoform-labeling gold particles found in the nucleoplasm
determination of the subcellular distribution of chromogranins A and B in chromaffin cells; results suggest that chromogranins are at the center of intracellular Ca(2 (show CA2 ELISA Kits)+) homeostasis in secretory cells
Chromogranin B was found to co-localize with secretogranin II (show SCG2 ELISA Kits) and IP3 receptors in the nucleus, more specifically, in the IP3-sensitive nucleoplasmic Ca2 (show CA2 ELISA Kits)+ store vesicles.
expression and localization of chromogranin A (CgA (show CHGA ELISA Kits)), chromogranin B (CgB), synaptophysin (show SYP ELISA Kits), and insulin (show INS ELISA Kits) were ultrastructurally studied with the immunogold technique in porcine and human pancreatic islet neuroendocrine cells
This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides.
, secretogranin I
, secretogranin B
, Chromogranin B, parathyroid secretory protein
, glucagonoma peptide