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Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin.
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Human Polyclonal C11orf30 Primary Antibody for ICC, IF - ABIN151977
Garapaty, Xu, Trojer, Mahajan, Neubert, Samuels: Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation. in The Journal of biological chemistry 2009
Altogether, 12 germline EMSY variants were observed in hereditary breast cancer and ovarian cancer families. Two alterations were located in the coding region, five alterations were intronic, and five alterations were located in the 3'untranslated region (UTR (show UTS2R Antibodies)). Variant frequencies did not differ between cases and controls. These results suggest that the identified EMSY variants are likely neutral at the population level.
We conclude that EMSY and CCND1 (show CCND1 Antibodies) work in collaboration and contribute to the pathogenesis of lung cancer.
Our results show a high frequency of EMSY amplification in MBC (show DOCK2 Antibodies), thus pointing to a role of EMSY in the pathogenesis of this disease. EMSY amplification may be a new feature that might uncover underlying molecular pathways of MBCs and may allow for the identification of MBC (show DOCK2 Antibodies) subgroups with potential clinical implication for targeted therapeutic approaches.
EMSY overexpression impairs the repair of damaged DNA, suggesting that EMSY belongs to the family of BRCAness proteins
identify a novel substoichiometric interactor of the complex, transcription factor ZNF131 (show ZNF131 Antibodies), which recruits EMSY to a large number of active, H3K4me3 marked promoters.
Eosinophilic esophagitis was associate with increased expression of C11orf30.
The association of higher levels of expression of C11orf30 may be involved in transcription repression of interferon (show IFNA Antibodies)-stimulated genes, and its association with sensitization to multiple allergens suggest that this locus is highly relevant for atopy.
Our study demonstrated that EMSY played an oncogenic role in the progression of ovarian cancer cells and EMSY might be a promising target for the treatment
Univariate analysis revealed a significant positive association between EMSY expression and lymph node metastasis, larger tumor size, as well as a non-significant relation with increased risk of recurrence.
EMSY is recruited to the miR (show MLXIP Antibodies)-31 promoter by the DNA binding factor ETS-1 (show ETS1 Antibodies), and it represses miR (show MLXIP Antibodies)-31 transcription by delivering the H3K4me3 demethylase (show MBD2 Antibodies) JARID1b/PLU-1 (show KDM5B Antibodies)/KDM5B (show KDM5B Antibodies)
Akt1 (show AKT1 Antibodies) regulates the interferon (show IFNA Antibodies) response through phosphorylation of the transcriptional repressor EMSY
Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2.
chromosome 11 open reading frame 30
, EMSY protein
, protein EMSY