anti-Chromosome 12 Open Reading Frame 52 (C12orf52) Antibodies

Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Additionally we are shipping Chromosome 12 Open Reading Frame 52 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
C12orf52 84934 Q96K30
Anti-Mouse C12orf52 C12orf52 100764 Q9D1H0
Anti-Rat C12orf52 C12orf52 288683 Q2KJ10
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Top anti-Chromosome 12 Open Reading Frame 52 Antibodies at antibodies-online.com

Showing 10 out of 25 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Alkaline Phosphatase (AP) ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details
Human Rabbit Biotin ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details
Human Rabbit APC ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details
Human Rabbit FITC ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details
Human Rabbit PE ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details
Human Rabbit HRP ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details
Human Rabbit Un-conjugated WB   400 μL 11 to 14 Days
$493.17
Details
Human Rabbit Un-conjugated ELISA, WB   200 μL 11 to 14 Days
$881.83
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemical staining of human rectum with C12orf52 polyclonal antibody  shows strong cytoplasmic and membranous positivity in glandular cells at 1:50-1:200 dilution. 100 μL 11 to 12 Days
$637.32
Details
Human Rabbit Cy7 IF (p)   100 μL 14 to 21 Days
$416.90
Details

More Antibodies against Chromosome 12 Open Reading Frame 52 Interaction Partners

Xenopus laevis Chromosome 12 Open Reading Frame 52 (C12orf52) interaction partners

  1. The study reports the identification and functional characterization of rbpj interacting and tubulin associated (RITA) (C12ORF52) as a novel rbpj/CBF-1-interacting protein.

Human Chromosome 12 Open Reading Frame 52 (C12orf52) interaction partners

  1. structural and biophysical studies demonstrate that RITA binds RBP-J similarly to the RAM (RBP-J-associated molecule) domain of Notch, our biochemical and cellular assays suggest that RITA interacts with additional regions in RBP-J.

  2. RITA overexpression increased expression of p53 and Fbxw7 and downregulated expression of cyclin D1, cyclin E, CDK2, Hes-1 and NF-kappaB p65. These changes led to growth inhibition and induced G0/G1 cell cycle arrest and apoptosis in SMMC7721 and HepG2 cells.

  3. human RITA, binding to Drosophila Su(H) and tubulin, cannot influence the Notch signalling pathway in the fly

  4. RITA might suppress tumor growth and induce apoptosis in hepatocellular carcinoma.

Mouse (Murine) Chromosome 12 Open Reading Frame 52 (C12orf52) interaction partners

  1. structural and biophysical studies demonstrate that RITA binds RBP-J similarly to the RAM (RBP-J-associated molecule) domain of Notch, our biochemical and cellular assays suggest that RITA interacts with additional regions in RBP-J.

Chromosome 12 Open Reading Frame 52 (C12orf52) Antigen Profile

Protein Summary

Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis (By similarity).

Gene names and symbols associated with C12orf52

  • RBPJ interacting and tubulin associated 1 (RITA1) antibody
  • RBPJ interacting and tubulin associated 1 L homeolog (rita1.L) antibody
  • RBPJ interacting and tubulin associated 1 (Rita1) antibody
  • AI853657 antibody
  • C12orf52 antibody
  • C86297 antibody
  • Rita antibody

Protein level used designations for C12orf52

chromosome 12 open reading frame 52 , RBP-J interacting and tubulin associated , RBPJ-interacting and tubulin-associated protein

GENE ID SPECIES
712837 Macaca mulatta
100381047 Xenopus laevis
84934 Homo sapiens
533158 Bos taurus
100764 Mus musculus
288683 Rattus norvegicus
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