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C12orf53 encodes a ligand for the paired immunoglobin-like type 2 receptor alpha, and so may be involved in immune regulation. Additionally we are shipping Chromosome 12 Open Reading Frame 53 Proteins (5) and many more products for this protein.
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Functionally, Leda-1/Pianp increased the transepithelial electrical resistance generated by a polarized cell sheet. While Claudin 1 and 4 expression and activities of small GTPases were not affected, gamma-Secretase-mediated cleavage of E-Cadherin was attenuated by Leda-1/Pianp.
Furin-like proprotein convertase-dependent processing precedes the plasma membrane localization of LEDA-1/PIANP that is required for functional receptor-ligand interactions in vitro and in vivo.
These results suggest that PANP is involved in immune regulation as a ligand of the PILRalpha.
This gene encodes a ligand for the paired immunoglobin-like type 2 receptor alpha, and so may be involved in immune regulation. Alternate splicing results in multiple transcript variants encoding different proteins.
PILR alpha-associated neural protein
, PILR-associating neural protein
, liver endothelial differentiation-associated protein-1
, paired immunoglobin-like type 2 receptor-associating neural protein
, chromosome 12 open reading frame 53