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May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.. Additionally we are shipping Chromosome 5 Open Reading Frame 39 Antibodies (27) and many more products for this protein.
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Overexpression of AX2R significantly inhibited cell proliferation, migration and tube formation in both types of endothelial cells and increased the expression of KLF2 (show KLF2 Proteins), mediating VEGF (show VEGFA Proteins) and VEGFR2 (show KDR Proteins).
Data highlighted the crucial role of AXIIR in reducing Mum2C cell viability through inducing apoptosis, while autophagy played a protective role in this process.
these subsequent effects might be via suppressing the expression of matrix metalloproteinase 2 (show MMP2 Proteins) and matrix metalloproteinase 9 (show MMP9 Proteins). ... AXIIR participates in angiogenesis, and may be a potential therapeutic target for angiogenesis related diseases
AXIIR acts as a novel inducer of apoptosis in human cells, partially through activating Caspase-8 (show CASP8 Proteins).
Results show that AXII and AXIIR play important roles in multiple myeloma (MM) and that targeting the AXII/AXIIR axis may be a novel therapeutic approach for MM.
analysis of the annexin II receptor on human marrow stromal cells
annexin II and its receptor axis play a central role in prostate cancer metastasis, and prostate cancer utilizes the hematopoietic stem cell homing mechanisms to gain access to the niche.
May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.
annexin II receptor
, annexin-2 receptor