Chromosome 9 Open Reading Frame 72 Proteins (C9ORF72)

Expansion of a hexanucleotide repeat in non-coding sequence between alternate 5' exons in transcripts from C9ORF72 is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Additionally we are shipping C9ORF72 Antibodies (78) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
C9ORF72 203228 Q96LT7
C9ORF72    
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Top C9ORF72 Proteins at antibodies-online.com

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
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Wheat germ Human GST tag 25 μg Log in to see 11 to 12 Days
$602.86
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Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see Available
$284.90
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Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$318.85
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C9ORF72 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)

More Proteins for Chromosome 9 Open Reading Frame 72 (C9ORF72) Interaction Partners

Human Chromosome 9 Open Reading Frame 72 (C9ORF72) interaction partners

  1. C9orf72 disease is clinically heterogeneous and without evident imaging markers

  2. that the overall frequency of C9orf72-positive cases in Greek FTD (show FTL Proteins) is high, comparable to Greek ALS (show IGFALS Proteins), similar to some Western European, but significantly higher than some Mediterranean FTD (show FTL Proteins) populations

  3. The C9orf72 repeat expansion linked to aggressive disease in male patients with spinal-onset ALS.

  4. The genetic mutations of C9ORF72 caused amyotrophic lateral sclerosis.

  5. Findings provide evidence that C9orf72 poly GA is a key mediator of cytotoxicity and that cross-talk between DPR (show DACT1 Proteins) proteins likely modifies their pathogenic status in C9ALS/FTD (show FTL Proteins).

  6. DNA methylation (show HELLS Proteins) analysis of C9orf72 patients revealed that increased DNAm age-acceleration is associated with a more severe disease phenotype with a shorter disease duration and earlier age of onset.

  7. This study demonstrated that poly-GA triggers behavioral deficits through inflammation and protein sequestration that likely contribute to the prodromal symptoms and disease progression of C9orf72 patients.

  8. A pathological repeat expansion in the C9orf72 gene (50 repeats) was found in a patient with mild diffuse brain atrophy and type 2 progressive apraxia of speech. This is the first described association of this gene with type 2 progressive speech apraxia.

  9. The association of the C9orf72 repeat expansion with ALS and frontotemporal degeneration.

  10. in common neurological diseases, intermediate C9orf72 repeats do not influence disease risk but may associate with higher frequency of neuropsychiatric symptoms

C9ORF72 Protein Profile

Protein Summary

Expansion of a hexanucleotide repeat in non-coding sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with C9ORF72

  • chromosome Z C9orf72 homolog (CZH9orf72)
  • chromosome 9 open reading frame 72 (C9orf72)
  • ALSFTD protein
  • CZH9orf72 protein
  • FTDALS protein

Protein level used designations for C9ORF72

protein C9orf72

GENE ID SPECIES
427370 Gallus gallus
203228 Homo sapiens
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