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The product of CLSPN is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. Additionally we are shipping Claspin Kits (4) and and many more products for this protein.
Showing 10 out of 22 products:
Human Polyclonal Claspin Primary Antibody for ICC, IF - ABIN151714
Li, Elder, Qin, Park, Liang, Zhao: Phosphatase type 2A-dependent and -independent pathways for ATR phosphorylation of Chk1. in The Journal of biological chemistry 2007
Show all 12 Pubmed References
Human Polyclonal Claspin Primary Antibody for WB - ABIN4298859
Jiang, Pereira, Maxfield, Russell, Goudelock, Sanchez: Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345. in The Journal of biological chemistry 2003
Show all 3 Pubmed References
Human Polyclonal Claspin Primary Antibody for IP, WB - ABIN151715
Gao, Inuzuka, Korenjak, Tseng, Wu, Wan, Kirschner, Dyson, Wei: Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways. in Molecular biology of the cell 2009
Show all 2 Pubmed References
The functions of claspin are discussed and how its deregulation may contribute to cancer initiation and progression. [REVIEW]
Results unveil a new aspect of PERK (show EIF2AK3 Antibodies) function and previously unknown roles for Claspin and Chk1 (show CHEK1 Antibodies) as negative regulators of DNA replication in the absence of genotoxic stress.
found that USP9X (show USP9X Antibodies) regulated the expression and stability of CLASPIN in an S-phase-specific manner. USP9X (show USP9X Antibodies) depletion profoundly impairs the progression of DNA replication forks, causing unscheduled termination events with a frequency similar to CLASPIN depletion, resulting in excessive endogenous DNA damage
Functional analyses indicat that the expression TopBP1 (show TOPBP1 Antibodies) and Claspin positively affects the survival of brain cancer cells after exposure to radiation.
And-1 coordinates with Claspin for efficient Chk1 (show CHEK1 Antibodies) activation in response to replication stress.
USP29 interacts with Claspin and is able to deubiquitinate it both in vivo and in vitro.
Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance.
findings identify claspin as an in vivo substrate for the BRCA1 E3 ligase and suggest that its modification selectively triggers CHK1 (show CHEK1 Antibodies) activation for the homology-directed repair of a subset of genotoxic lesions
analysis of claspin expression could be clinically relevant in the diagnosis of HPV-related cervical lesions, in particular when applied to cervico-vaginal cytology
The conserved C terminus of Claspin interacts with Rad9 (show RAD9A Antibodies) and ensures timely activation of the ATR (show ANTXR1 Antibodies)-Chk1 (show CHEK1 Antibodies) pathway.
Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1 (show TOPBP1 Antibodies)) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR (show ATR Antibodies)) phosphorylation of checkpoint kinase 1 (Chk1 (show CHEK1 Antibodies)).
Rad9A (show RAD9A Antibodies)-mediated Claspin localization is a vital step during checkpoint activation.
Claspin localizes to mitotic centromeres depending on mitotic SUMOylation.
Claspin is phosphorylated at the midblastula transition at both DNA replication checkpoint-dependent and -independent sites.
recent findings and mechanisms of checkpoint regulation by claspin
the interaction of DDK with Claspin mediates a checkpoint-independent function of Claspin related to DNA replication.
Claspin has roles in the Chk1 (show CHEK1 Antibodies) pathway and functions in checkpoint control [review]
our findings suggest that only transient interaction of Claspin with replication forks potentiates its Chk1 (show CHEK1 Antibodies)-activating function. Also, stable binding of Claspin to chromatin may play a role in other functions besides the activation of Chk1 (show CHEK1 Antibodies).
The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene.
claspin homolog (Xenopus laevis)
, claspin homolog