anti-Claspin (CLSPN) Antibodies

The product of CLSPN is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. Additionally we are shipping Claspin Kits (4) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CLSPN 298534  
CLSPN 63967 Q9HAW4
CLSPN 269582 Q80YR7
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Top anti-Claspin Antibodies at antibodies-online.com

Showing 10 out of 25 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated ELISA, IHC, WB ABIN6271677 at 1/200 staining Human kidney tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. ABIN6271677 at 1/200 staining Mouse brain tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL 11 to 12 Days
$450.00
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of Claspin using HUVEC whole cell lysates ABIN6277738 at 1/100 staining Human gastric tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$419.83
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL 11 to 13 Days
$335.04
Details
Human Rabbit Un-conjugated WB Western blot analysis Claspin (pS30) using COLO205 whole cell lysates. 100 μg 11 to 16 Days
$454.83
Details
Human Rabbit Un-conjugated IP, WB   100 μL 2 to 3 Days
$245.00
Details
Human Rabbit Un-conjugated IP, WB   100 μL 11 to 14 Days
$595.83
Details
Human Rabbit Un-conjugated IF, IHC, IHC (p), IP, PLA, WB   100 μL 11 to 14 Days
$595.83
Details
Human Rabbit Un-conjugated WB   100 μL 11 to 14 Days
$595.83
Details
Human Rabbit Un-conjugated ELISA, IF, IP, WB   100 μg 13 to 16 Days
$380.00
Details

Top referenced anti-Claspin Antibodies

  1. Human Polyclonal Claspin Primary Antibody for ICC, IF - ABIN151714 : Li, Elder, Qin, Park, Liang, Zhao: Phosphatase type 2A-dependent and -independent pathways for ATR phosphorylation of Chk1. in The Journal of biological chemistry 2007 (PubMed)
    Show all 12 Pubmed References

  2. Human Polyclonal Claspin Primary Antibody for WB - ABIN4298859 : Jiang, Pereira, Maxfield, Russell, Goudelock, Sanchez: Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345. in The Journal of biological chemistry 2003 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal Claspin Primary Antibody for IP, WB - ABIN151715 : Gao, Inuzuka, Korenjak, Tseng, Wu, Wan, Kirschner, Dyson, Wei: Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways. in Molecular biology of the cell 2009 (PubMed)
    Show all 2 Pubmed References

More Antibodies against Claspin Interaction Partners

Human Claspin (CLSPN) interaction partners

  1. Claspin is a cell cycle checkpoint adaptor and DNA replication factor. (Review)

  2. the data indicate that enhanced levels of Claspin and Timeless represent a gain of function that protects cancer cells from oncogene-induced replication stress in a checkpoint-independent manner.

  3. The functions of claspin are discussed and how its deregulation may contribute to cancer initiation and progression. [REVIEW]

  4. Results unveil a new aspect of PERK function and previously unknown roles for Claspin and Chk1 as negative regulators of DNA replication in the absence of genotoxic stress.

  5. found that USP9X regulated the expression and stability of CLASPIN in an S-phase-specific manner. USP9X depletion profoundly impairs the progression of DNA replication forks, causing unscheduled termination events with a frequency similar to CLASPIN depletion, resulting in excessive endogenous DNA damage

  6. Functional analyses indicat that the expression TopBP1 and Claspin positively affects the survival of brain cancer cells after exposure to radiation.

  7. And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stress.

  8. USP29 interacts with Claspin and is able to deubiquitinate it both in vivo and in vitro.

  9. Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance.

  10. findings identify claspin as an in vivo substrate for the BRCA1 E3 ligase and suggest that its modification selectively triggers CHK1 activation for the homology-directed repair of a subset of genotoxic lesions

  11. analysis of claspin expression could be clinically relevant in the diagnosis of HPV-related cervical lesions, in particular when applied to cervico-vaginal cytology

  12. The conserved C terminus of Claspin interacts with Rad9 and ensures timely activation of the ATR-Chk1 pathway.

  13. the functions of Claspin and the functional relationship between Claspin and Rad17 were studied.

  14. In the presence of BRCA1, endogenous HERC2 interacts with Claspin, a protein essential for G(2)-M checkpoint activation and replication fork stability.

  15. The multiple protein-DNA and protein-protein interactions is important for Claspin function during DNA replication and DNA replication checkpoint signaling.

  16. Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR) phosphorylation of checkpoint kinase 1 (Chk1).

  17. Here, the authors demonstrate that both the NF-kappaB family of transcription factors and their upstream kinase IKK can regulate Claspin levels by controlling its mRNA expression.

  18. RPA-covered ssDNA not only supports recruitment and activation of ATR but also, through Tipin and Claspin, it plays an important role in the action of ATR on its critical downstream target Chk1

  19. Rad9A-mediated Claspin localization is a vital step during checkpoint activation.

  20. Data show that the ATR-dependent phosphorylation of Chk1, but not p53, is strongly stimulated by Claspin.

Mouse (Murine) Claspin (CLSPN) interaction partners

  1. Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR) phosphorylation of checkpoint kinase 1 (Chk1).

  2. Rad9A-mediated Claspin localization is a vital step during checkpoint activation.

Xenopus laevis Claspin (CLSPN) interaction partners

  1. Claspin is a cell cycle checkpoint adaptor and DNA replication factor. (Review)

  2. Claspin localizes to mitotic centromeres depending on mitotic SUMOylation.

  3. Claspin is phosphorylated at the midblastula transition at both DNA replication checkpoint-dependent and -independent sites.

  4. recent findings and mechanisms of checkpoint regulation by claspin

  5. the interaction of DDK with Claspin mediates a checkpoint-independent function of Claspin related to DNA replication.

  6. Claspin has roles in the Chk1 pathway and functions in checkpoint control [review]

  7. our findings suggest that only transient interaction of Claspin with replication forks potentiates its Chk1-activating function. Also, stable binding of Claspin to chromatin may play a role in other functions besides the activation of Chk1.

Claspin (CLSPN) Antigen Profile

Protein Summary

The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with anti-Claspin (CLSPN) Antibodies

  • claspin (Clspn) antibody
  • claspin (CLSPN) antibody
  • claspin (clspn) antibody
  • claspin S homeolog (clspn.S) antibody
  • B130025E01 antibody
  • C85083 antibody
  • CLSPN antibody
  • E130314M08Rik antibody
  • xClaspin antibody

Protein level used designations for anti-Claspin (CLSPN) Antibodies

claspin homolog (Xenopus laevis) , claspin , claspin homolog , hClaspin , xClaspin

GENE ID SPECIES
298534 Rattus norvegicus
100055244 Equus caballus
456746 Pan troglodytes
100124314 Xenopus (Silurana) tropicalis
100347850 Oryctolagus cuniculus
100482920 Ailuropoda melanoleuca
100525928 Sus scrofa
100543387 Meleagris gallopavo
100567034 Anolis carolinensis
100597024 Nomascus leucogenys
63967 Homo sapiens
269582 Mus musculus
398192 Xenopus laevis
Selected quality suppliers for anti-Claspin (CLSPN) Antibodies
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