Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. Additionally we are shipping Cleavage and Polyadenylation Specific Factor 1, 160kDa Kits (5) and Cleavage and Polyadenylation Specific Factor 1, 160kDa Proteins (3) and many more products for this protein.
Showing 10 out of 18 products:
cpsf1 is essential for hematopoietic stem cell survival and differentiation in caudal (show CAD Antibodies) hematopoietic tissue
Knockdown of CPSF (show CPSF3 Antibodies) inhibits the proliferation, migration and invasion of ovarian carcinoma cells.
The authors define the molecular architecture of the core human CPSF (show CPSF3 Antibodies) complex comprising CPSF160, WDR33 (show WDR33 Antibodies), CPSF30 (show CPSF4 Antibodies) and Fip1 (show RRAGA Antibodies) and identify specific domains involved in inter-subunit interactions. Together, these results shed light on the function of CPSF (show CPSF3 Antibodies) in mediating polyA signal-dependent RNA cleavage and polyadenylation.
CPSF1 was identified among protein-binding candidates. A consensus polyadenylation signal AAUAAA is present in intron 6 of IL7 (show IL7 Antibodies) receptor directly downstream from the 5' splice site. Mutations to this site and CPSF1 knockdown increased exon 6 inclusion.
Data report that PABPN1 (show PABPN1 Antibodies) is required to restrict CPSF (show CPSF2 Antibodies) binding to the AAUAAA sequence and to permit the stimulation of poly(A) polymerase (show PAPOLA Antibodies) by AAUAAA-bound CPSF (show CPSF2 Antibodies) to be maintained throughout the elongation reaction.
Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995
cleavage and polyadenylation specificity factor subunit 1
, cleavage and polyadenylation specificity factor
, cleavage and polyadenylation specificity factor 160
, drosophila cleavage and polyadenylation stimulation factor-160
, cleavage and polyadenylation specific factor 1, 160kDa
, CPSF 160 kDa subunit
, cleavage and polyadenylation specificity factor 1
, cleavage and polyadenylation specificity factor 160 kDa subunit
, polyadenylation specificity factor