anti-Coiled-Coil Domain Containing 6 (CCDC6) Antibodies

CCDC6 encodes a coiled-coil domain-containing protein. Additionally we are shipping CCDC6 Proteins (4) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CCDC6 8030 Q16204
CCDC6 76551 D3YZP9
CCDC6 691155  
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Top anti-CCDC6 Antibodies at antibodies-online.com

Showing 10 out of 62 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-Ccdc6 Antibody Titration: 1.0 ug/ml Positive Control: Mouse Liver 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of CCDC6 expression in rat testis extract ( Lane 1) and MCF-7 whole cell lysates ( Lane 2). CCDC6 at 66KD was detected using rabbit anti- CCDC6 Antigen Affinity purified polyclonal antibody (Catalog # ) at 0.5 ??g/mL. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002). 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunocytochemistry/Immunofluorescence: CCDC6 Antibody [NBP1-85350] Staining of human cell line U-2 OS shows positivity in cytoplasm. Immunohistochemistry-Paraffin: CCDC6 Antibody [NBP1-85350] - Staining of human urinary bladder shows moderate cytoplasmic positivity in urothelial cells. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: CCDC6 Antibody [NBP1-85351] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp Immunohistochemistry-Paraffin: CCDC6 Antibody [NBP1-85351] - Staining of human fallopian tube shows distinct cytoplasmic positivity in glandular cells. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Rabbit Un-conjugated WB CCDC6 Antibody (N-term) (ABIN1881146) western blot analysis in K562 cell line lysates (35 µg/lane). This demonstrates the CCDC6 antibody detected the CCDC6 protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated WB Western Blot: CCDC6 Antibody [NBP1-31882] - Sample (30 ug of whole cell lysate) A: H1299 B: Hela 10% SDS PAGE; antibody diluted at 1:1000. 0.1 mL Log in to see 8 to 11 Days
$516.98
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$507.83
Details
Mouse Rabbit Un-conjugated WB Western Blot: CCDC6 Antibody [NBP1-98370] - Titration: 1.0 ug/ml Positive Control: Mouse Liver. 100 μL Log in to see 8 to 11 Days
$488.73
Details
Human Mouse Un-conjugated WB Western Blot analysis of CCDC6 expression in transfected 293T cell line by CCDC6 MaxPab polyclonal antibody.Lane 1: CCDC6 transfected lysate(52.14 KDa).Lane 2: Non-transfected lysate. 50 μL Log in to see 11 to 12 Days
$440.00
Details
Human Mouse Un-conjugated ELISA, WB   100 μg Log in to see 11 to 14 Days
$537.17
Details

Top referenced anti-CCDC6 Antibodies

  1. Human Polyclonal CCDC6 Primary Antibody for WB - ABIN1881146 : Leone, Mansueto, Pierantoni, Tornincasa, Merolla, Cerrato, Santoro, Grieco, Scaloni, Celetti, Fusco: CCDC6 represses CREB1 activity by recruiting histone deacetylase 1 and protein phosphatase 1. in Oncogene 2010 (PubMed)
    Show all 5 Pubmed References

More Antibodies against CCDC6 Interaction Partners

Human Coiled-Coil Domain Containing 6 (CCDC6) interaction partners

  1. FGFR inhibitors, particularly BGJ398, are therapeutic options for cholangiocarcinoma patients harboring FGFR2-CCDC6 fusions.

  2. Our findings nevertheless suggest that CCDC6-RET fusions identified by multiplex testing are potential targets for nintedanib therapy.

  3. we propose that the amount of CCDC6 protein in primary tumors, as reported in lung, may depend on the impairment of the CCDC6 turnover due to altered protein-protein interaction and post-translational modifications

  4. Results show that RNA-binding protein EWS binds and regulates CCDC6 expression at RNA and protein levels.

  5. CCDC6 levels provide valuable insight for OS.

  6. the loss of CCDC6 could aid the spermatogonial cells to be part of a pro-survival pathway that helps to evade the toxic effects of endogenous oxidants and contributes to testicular neoplastic growth.

  7. Expression of the CCDC6-RET fusion gene in LC-2/ad cells was demonstrated by the mRNA and protein levels, and the genomic break-point was confirmed by genomic DNA sequencing.

  8. CCDC6 is associated with cAMP signaling by fine regulating CREB1 transcriptional activity in normal and transformed thyroid cells.

  9. CCDC6-RET fusion is associated with lung adenocarcinoma.

  10. It was shown that FBXW7 interacts with and targets CCDC6 for ubiquitin-mediated proteasomal degradation. FBXW7-mediated CCDC6 degradation was impaired in response to DNA damage.

  11. Following genotoxic stress, loss or inactivation of CCDC6 in cancers that carry the CCDC6 fusion, accelerates the dephosphorylation of pH2AX S139, resulting in defective G2 arrest and premature mitotic entry.

  12. CCDC6 plays a key role in cell cycle control.

  13. we discovered previously unidentified kinase fusions that may be promising for molecular-targeted therapy, kinesin family member 5B (KIF5B)-ret proto-oncogene (RET) and coiled-coil domain containing 6 (CCDC6)-RET, in 14 adenocarcinomas

  14. down-regulation of 14-3-3sigma in the absence of CCDC6 demonstrated their direct association and supports the notion that CCDC6 contributes to cancer development, possibly through malignant pathways involving 14-3-3sigma

  15. repression of CREB1 activity by CCDC6 has a critical function in the development of human thyroid papillary carcinomas carrying RET/PTC1 activation.

  16. H4(D10S170) is involved in the cellular response to ataxia telangectasia mutated (ATM) kinase; impairment of H4(D10S170) gene function might have a role in thyroid carcinogenesis.

  17. frequency of the occurrence of BRAF mutation and/or RET/PTC in H4-PTEN positive tumors was extremely high (75%) in papillary thyroid carcinoma

  18. PTC1 and PTC3 are highly oncogenic proteins when overexpressed, but result in indolent disease compared with RET-related MTCs due to their relatively low expression from the NCOA4 and CCDC6 promoters in vivo.

Mouse (Murine) Coiled-Coil Domain Containing 6 (CCDC6) interaction partners

  1. Ccdc6-ex2 knock-in mice developed thyroid hyperplasia associated with an enhanced CREB1 activity and an increased expression of the CREB-1 regulated genes.

  2. the loss of CCDC6 could aid the spermatogonial cells to be part of a pro-survival pathway that helps to evade the toxic effects of endogenous oxidants and contributes to testicular neoplastic growth.

CCDC6 Antigen Profile

Protein Summary

This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.

Gene names and symbols associated with CCDC6

  • coiled-coil domain containing 6a (ccdc6a) antibody
  • coiled-coil domain containing 6 S homeolog (ccdc6.S) antibody
  • coiled-coil domain containing 6 (CCDC6) antibody
  • coiled-coil domain containing 6 (Ccdc6) antibody
  • 2810012H18Rik antibody
  • AA536681 antibody
  • AA960498 antibody
  • AW061011 antibody
  • ccdc6 antibody
  • D10S170 antibody
  • fj36e04 antibody
  • H4 antibody
  • MGC53501 antibody
  • PTC antibody
  • TPC antibody
  • TST1 antibody
  • wu:fj36e04 antibody
  • zgc:56563 antibody
  • zgc:77435 antibody

Protein level used designations for CCDC6

coiled-coil domain-containing protein 6 , coiled-coil domain containing 6 , papillary thyroid carcinoma-encoded protein

GENE ID SPECIES
335905 Danio rerio
379300 Xenopus laevis
100224200 Taeniopygia guttata
8030 Homo sapiens
423666 Gallus gallus
488993 Canis lupus familiaris
100155896 Sus scrofa
522998 Bos taurus
76551 Mus musculus
691155 Rattus norvegicus
Selected quality suppliers for anti-CCDC6 (CCDC6) Antibodies
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