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CCDC8 encodes a coiled-coil domain-containing protein.
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Variants near TTN (show TTN Proteins) and CCDC8 were associated with KI67 (show MKI67 Proteins) expression, and rs2288563 and rs2562832 in TTN (show TTN Proteins) are potential biomarkers for the prediction of clinical outcomes in hepatitis B-related hepatocellular carcinoma patients.
CCDC8 may suppress the invasion and metastasis of non-small cell lung cancer cells.
CUL7, OBSL1 and CCDC8 modulate the alternative splicing of the INSR (show INSR Proteins)
The CUL7, OBSL1, and CCDC8 proteins form a 3M complex that functions in maintaining microtubule and genome integrity and normal development.
Mutations in CUL7, OBSL1 and CCDC8 in 3-M syndrome lead to disordered growth factor signalling.
discussion of roles of CCDC8, CUL7 (cullin 7), and OBSL1 (obscurin-like 1) in growth and development using findings from patients with Miller-McKusick-Malvaux syndrome and Silver-Russell syndrome [REVIEW]
p90 (show CANX Proteins) is a critical cofactor for p53 (show TP53 Proteins)-mediated apoptosis through promoting Tip60 (show KAT5 Proteins)-mediated p53 (show TP53 Proteins) acetylation.
We propose that CUL7, OBSL1, and CCDC8 are members of a pathway controlling mammalian growth.
This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a cofactor required for p53-mediated apoptosis following DNA damage, and may also play a role in growth through interactions with the cytoskeletal adaptor protein obscurin-like 1. Mutations in this gene are a cause of 3M syndrome-3 (3M3).
coiled-coil domain-containing protein 8
, protein phosphatase 1, regulatory subunit 20
, probable Coiled-coil domain-containing protein 8
, coiled-coil domain-containing protein 8 homolog