Collagen, Type I, alpha 2 Proteins (COL1A2)

COL1A2 encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Additionally we are shipping Collagen, Type I, alpha 2 Antibodies (119) and Collagen, Type I, alpha 2 Kits (78) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
COL1A2 1278 P08123
COL1A2 12843 Q01149
Rat COL1A2 COL1A2 84352 P02466
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Top Collagen, Type I, alpha 2 Proteins at antibodies-online.com

Showing 9 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,984.89
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,984.89
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Dog Un-conjugated SDS-PAGE analysis of Dog COL1A2 Protein. 100 μg Log in to see 11 to 18 Days
$668.03
Details
Yeast Rabbit His tag   1 mg Log in to see 60 to 71 Days
$2,678.50
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$656.00
Details
Escherichia coli (E. coli) Chicken Un-conjugated   100 μg Log in to see 11 to 18 Days
$653.82
Details
Escherichia coli (E. coli) Cow Un-conjugated   100 μg Log in to see 11 to 18 Days
$653.82
Details
Escherichia coli (E. coli) Rabbit Un-conjugated   100 μg Log in to see 11 to 18 Days
$653.82
Details

COL1A2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Collagen, Type I, alpha 2 (COL1A2) Interaction Partners

Human Collagen, Type I, alpha 2 (COL1A2) interaction partners

  1. Osteogenesis imperfecta with ectopic mineralizations in dentin and cementum and a COL1A2 mutation has been reported in a Thai adult patient and his preschool daughter.

  2. Mutations in the COL1A1 (show COL1A1 Proteins) and COL1A2 genes associated with osteogenesis imperfecta (OI) types I or III.

  3. High COL1A2 expression is associated with Gastric Cancer.

  4. The aim of this study is to determine whether EcoRI, Del38 and PvuII polymorphisms of COL1A2 are associated with the development of osteoporosis and osteopenia in post-menopausal Polish women. The analyzed COL1A2 polymorphisms seem to be related to osteoporosis development. The COL1A2 polymorphism may be a genetic risk factor related to the development of osteoporosis.

  5. the efficacy of pamidronate treatment does not seem to be related to the genotype of type I collagen in patients with osteogenesis imperfecta.

  6. COL1A2 gene mutation is associated with osteogenesis imperfecta.

  7. We evaluated the association of a 7-base pair (7-bp) indel polymorphism (rs3917) in the 3'UTR of COL1A2 with the risk of sudden cardiac death in a Chinese population. Our data provided initial evidence that rs3917 was highly relevant to SCD (show SCD Proteins) susceptibility, and this indel may become a potential marker for molecular diagnosis and genetic counseling of SCD (show SCD Proteins).

  8. meta-analysis suggests COL1A2 rs42524 is a significant risk factor for Intracranial Aneurysm susceptibility.

  9. mutations of the COL1A1 (show COL1A1 Proteins) and COL1A2 genes probably underlie the disease in the four families

  10. By acting probably as a posttranscriptional regulator with a different efficacy on COL2A1 (show COL2A1 Proteins) and COL1A2 expression, miR (show MLXIP Proteins)-29b can contribute to the collagens imbalance associated with an abnormal chondrocyte phenotype.

Cow (Bovine) Collagen, Type I, alpha 2 (COL1A2) interaction partners

  1. In advanced stage granulomas in Mycobacterium bovis-infected cattle, there was an increase in the expression of type I procollagen

  2. Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.

Mouse (Murine) Collagen, Type I, alpha 2 (COL1A2) interaction partners

  1. miR (show MLXIP Proteins)-26b-5p interacted with 3'UTRs of Col1a2 and CTGF (show CTGF Proteins), and circ_000203 could block the interactions of miR (show MLXIP Proteins)-26b-5p and 3'UTRs of Col1a2 and CTGF (show CTGF Proteins).

  2. mouse with a Gly610 to cysteine (Cys (show DNAJC5 Proteins)) substitution in the procollagen alpha2(I) chain show misfolded procollagen accumulation in the endoplasmic reticulum leads to an unusual form of cell stress.

  3. these results indicate that mutant collagen alpha2(I) chain affects both bone quantity and composition.

  4. Activation of COL1A2 transcription by HIF-1alpha (show HIF1A Proteins) occurred in the absence of hypoxia and is strongly enhanced by TGF-beta (show TGFB1 Proteins) signaling.

  5. Identify PDGFRbeta as a driver in activating Akt (show AKT1 Proteins)/mTORC1 nexus for high glucose-mediated expression of collagen I (alpha2) in proximal tubular epithelial cells, which contributes to tubulointerstitial fibrosis in diabetic nephropathy.

  6. Insulin receptor substrate-1 (show IRS1 Proteins) time-dependently regulates bone formation by controlling collagen Ialpha2 expression via miR (show MLXIP Proteins)-342

  7. Type I collagen was highly expressed in the spinal cord during the scar-forming phase and induced astrocytic scar formation via the integrin-N-cadherin (show CDH2 Proteins) pathway.

  8. evidence that FOXL2 (show FOXL2 Proteins) modulates Col1a2 transcription through interaction with a response element 65 Kb upstream of the transcription start site

  9. Data indicate that insulin-like growth factor 1 (IGF1 (show IGF1 Proteins)) could promote collagen I alpha 2 (COL1A2) expression and osteoblast differentiation in primary pre-osteoblasts by increasing La ribonucleoprotein domain family member 6 (Larp6 (show LARP6 Proteins)) expression via a posttranscriptional mechanism.

  10. The phosphorylation sequence matched that targeted by Casein Kinase 2, and inhibition of this kinase activity disrupted the ability of scleraxis to modulate the expression of its target genes while also attenuating TGFbeta (show TGFB1 Proteins)-induced expression of type I collagen and myofibroblast phenotype conversion marker genes

Pig (Porcine) Collagen, Type I, alpha 2 (COL1A2) interaction partners

Zebrafish Collagen, Type I, alpha 2 (COL1A2) interaction partners

  1. ven though in adult bone, skin and scales equal amounts of a1(col1a1a) a2(col1a2) and a3(col1a2)chains are present, the presented data suggest a tissue-specific stoichiometry and/or post-translational modification status for collagen type I

Collagen, Type I, alpha 2 (COL1A2) Protein Profile

Protein Summary

This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

Gene names and symbols associated with COL1A2

  • collagen type I alpha 2 chain (COL1A2)
  • collagen type I alpha 2 L homeolog (col1a2.L)
  • collagen, type I, alpha 2 (Col1a2)
  • collagen type I alpha 2 chain (Col1a2)
  • collagen, type I, alpha 2 (col1a2)
  • AA960264 protein
  • AI325291 protein
  • alpha2(I) protein
  • Col1a-2 protein
  • Cola-2 protein
  • Cola2 protein
  • hm:zehn2357 protein
  • OI4 protein
  • oim protein
  • wu:fa98d05 protein
  • wu:fa99g10 protein
  • wu:fb04c08 protein
  • wu:fb11d06 protein
  • zehn2357 protein

Protein level used designations for COL1A2

procollagen, type I, alpha 2 , alpha 2(I) collagen , alpha-2 type I collagen , alpha-2(1) collagen , collagen alpha 2(I) chain , collagen alpha-2(I) chain , alpha 2(I)-collagen , collagen I, alpha-2 polypeptide , collagen of skin, tendon and bone, alpha-2 chain , type I procollagen , COL1A2 gene exons 8 through 12 , type I procollagen pro-alpha 2 chain , alpha 2(I) procollagen , collagen I alpha-2 polypeptide , collagen COL1A2 , osteogenesis imperfecta , alpha 2 type I collagen , collagen a2(I)

GENE ID SPECIES
100860940 Capra hircus
380419 Xenopus laevis
396243 Gallus gallus
1278 Homo sapiens
403824 Canis lupus familiaris
282188 Bos taurus
100008997 Oryctolagus cuniculus
12843 Mus musculus
84352 Rattus norvegicus
100719158 Cavia porcellus
100626716 Sus scrofa
336471 Danio rerio
100135811 Oncorhynchus mykiss
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